Endocrine Abstracts

Benign prostate hyperplasia (BPH) is the most common disease in the aging male, often comorbid with erectile dysfunction (ED). PDE5 inhibitors (PDE5i, sildenafil, tadalafil and vardenafil) decrease lower urinary tract symptoms (LUTS) in patients with ED and BPH. We studied PDE5 expression and activity in the human bladder and PDE5i effects both in vitro (human and rat) and in vivo (rat). PDE5 is highly expressed in rat and human bladder and immunolocalized in vas...

CRF mediates numerous complementary stress-related endocrine (HPA), autonomic and behavioral responses. CRF antagonists block many stress-induced responses in experimental animals. Furthermore, perturbations of the CRF system or HPA have been reported in human affective disorders. CRF acts through two Class B G protein coupled receptors derived from two genes, which have alternative splice variants and distinct expression patterns. Mice null for CRF-R1 exhibit reduced basal an...

It is now well known that peripheral nervous system (PNS) is able to synthesize neurosteroids and to convert them, or hormonal steroids coming from the periphery, in neuroactive steroids. Moreover, PNS possess both classical (e.g., progesterone receptor, PR, androgen receptor, AR) and non-classical (e.g., GABAA receptor) steroid receptors and consequently may represent a target for the action of neuroactive steroids. Our data have indicated that neuroactive steroids, like for ...

Introduction: Primary amyloidosis is a multi-systemic disease difficult to identify given the diversity of the disorders that it can cause especially at an early stage of the disease. This makes its diagnosis difficult in case of association with a pathology that can be intricate with its clinical expression. In this context we report the first case in the literature associating mitochondrial diabetes (DM) with a primary amyloidosisCase: A 32 years old g...

Hypothyroidism therapy is based on the administration of appropriate dose of L-thyroxine (L-T4). Absorption of L-T4 takes place in the duodenum and upper tract of the small intestine (jejunum), is maximal when stomach is empty, and is affected by a number of gastrointestinal disorders, including Helicobacter pylori–related gastritis, as well as ingestion of drugs, dietary fibers, and herbal remedies. Failure to achieve a good control of disease may be due to malabsorption...

Introduction: Parapharyngeal abscesses develop at the pharyngeal lateral wall. It is a rare infectious complication. The starting point is most often a pharyngeal infection that extends through the fibers of the upper constrictor muscles of the pharynx. The dental origin is more rare. It raises the problem of therapeutic management. The aim of this presentation was to detail the clinical diagnostic aspects of parapharyngeal abscesses in diabetics and to detail the therapeutic ...

IntroductionMarfan syndrome is a rare autosomal dominant genetic disease resulting from a mutation in the gene encoding type 1 fibrillin (FBN1), which is a glycoprotein in the composition of elastic fibers in connective tissue. It mainly affects the cardiovascular, musculoskeletal and ocular systems.Case presentationWe report the case of a 14-year-old girl, with no particular history, referred to an endocrino...

Patients with gonadotoxicity due to disease treatment, or who face primary gonadal insufficiency as a result of genetic causes, have limited options for long-term endocrine and fertility support. Current fertility options, such as egg or embryo banking, exclude women with hormone-responsive cancers and pre-pubertal children. This highlights the urgency of addressing this currently unmet need with innovative engineering solutions. Our objective is to create an ovary bioprosthes...

Hyponatremia is the most frequent electrolytic disorder in clinical practice. It is estimated that in about 50% of cases hyponatremia is secondary to the syndrome of inappropriate antidiuresis (SIAD). Hyponatremia is associated with a worse outcome and with increased mortality in several diseases, including cancer. In vitro and in vivo evidence shows that low [Na+ ] is associated with neurological and extra-neurological alterations, which include f...

Background: Hypokalemic Thyrotoxic Periodic Paralysis (HTPP) is a rare acquired muscular channelopathy that develops in the context of thyrotoxicosis. It consists of episodes of painless muscle weakness, precipitated by exercise, fasting, or high-carbohydrate meals. Men among ages 20-40 are more frequently affected than woman. Thyrotoxicosis (and its subsequent beta-adrenergic stimulation) increases the activation of the Sodium-Potassium ATPase channels, which leads to hyperpo...