Endocrine Abstracts

Studies have demonstrated that ATP-sensitive potassium channel (KATP) subunits SUR2A (sulfonylurea receptor) and KIR6.2 are involved in glucose uptake into skeletal muscle. It is known that the glucose transporter 4 (GLUT4) expression is highest in oxidative type I fibers, pointing out the important role of oxidative muscles as glucose uptakes. Considering these aspects the aim of this study was to investigate whether KATP channel can influence glucose uptake in oxidative musc...

Introduction: Schwachman–Diamond syndrome (SDS) is usually manifested with exocrine pancreatic insufficiency, short stature, and chronic neutropenia. SDS associated with osteoporosis and diabetes mellitus (DM) presenting with ketoacidosis is quite rare.Case: A 29-year-old woman was admitted to emergency room with symptoms of frequent urination and confusion. She had not history of diabetes mellitus or any other disease. On her examination, she had n...

Introduction: The Gasser Ganglion is a large semi lunar-shaped ganglion of the trigeminal nerve. It contains the cells of origin of the most sensory fibers of the fifth cranial nerve.Aim: Our purpose is to describe a case where Gasser ganglion has an anatomic variant (near the sella turcica), mimicking a hypophyseal tumor.Case presentation: Of 17 years female patient has a history of bradispaniomenorrhea (menses at 30–50 days)...

Objective: Stress causes negative effects at all the body especially the heart. As a result of the damage of secreting various hormones which stress cause to secrete in the body. During the stress, respiration, tension, heart speed and catecholamine level increase. All these can be considered as a risk factor for the heart disease. In our study, we aimed to examine stress’ possible histopathological changes on heart muscle.Methods: Eight adult femal...

Dysfunctional mitochondrial oxidative phosphorylation and diminished aerobic capacity are associated with metabolic, cardiovascular and neurodegenerative diseases that eventually alter life span. We will discuss two distinct signalling pathways to control energy expenditure that converge on the coactivator PGC-1α. In a first study we focussed on the polyphenol resveratrol, an activator of the class III HDAC SIRT1, the mammalian Sir2 homolog. Resveratrol significantly incr...

The ability of local invasion and distant metastasis indicates malignancy. Focal adhesion complex plays an important role during cell invasion. This complex consists of integrins, focal adhesion kinase (FAK), vinculin, talin, α-actinin and paxillin. Activation of FAK regulates the assembly of focal adhesion and stress fiber formation via GTPase Rho and Rac, which is responsible for the migratory behavior of cells. In this study, we demonstrated the inhibitory effect of ro...

Dopamine receptors (DR) are expressed in the majority of corticotroph pituitary tumors and the dopamine agonist cabergoline is effective in controlling cortisol hypersecretion in around 50% of patients with Cushing’s disease (CD). In order to characterize the tumors expressing D2 receptors and the profile of patients which might respond to the treatment with D2 agonists, the current study has the aim to correlate D2 receptor expression and...

Hexose-6-phosphate dehydrogenase (H6PD) is a sarcoplasmic reticulum (SR) resident enzyme that metabolizes glucose-6-phosphate and generates NADPH that drives the activation of glucocorticoids by 11β-hydroxysteorid dehydrogenase type 1. H6PD KO mice exhibit improved skeletal muscle insulin sensitivity increased glucose uptake and glycogen storage. However, H6PD KO mice also develop a myopathy with switching from Type II to Type I fibers. Affected muscles have apparently no...

Central control of body weight involves coordinated regulation of food intake and energy metabolism. White (WAT) and brown (BAT) adipose tissue represent functionally distinct compartments of lipid storage and fuel consumption, respectively. Both adipose tissues are innervated by the sympathetic nervous system. Tyrosine hydroxylase positive fibers were found in between fat cells. To determine the extent to which the control of different fat compartments is provided by the same...

Reports in the literature have demonstrated an increased number of nerve fibers and the presence of a follicle development similar to polycystic ovary during perimenopausal ovary in women. Since differentiation, proliferation and growth of nerves depends of nerve growth factor (NGF), changes in the content of nerves fiber could be preceded by increases in NGF and p75 neurotrophin receptor (p75NTR). Our purpose was to evaluate the changes in noradrenaline (NA) at the celiac gan...