Endocrine Abstracts

Background: Immune checkpoint inhibitors (ICIs) have modified the outcome of several advanced malignancies. Thyroid dysfunctions (DYSTHYR) are the most common endocrine immune-related adverse events (IRAEs) during treatment with the programmed cell death protein-1 (PD-1) and its ligand (PD-L1) inhibitors. Data regarding predictive biomarkers enabling stratification of DYSTHYR risk are still limited.Patients and methods: We retrospectively analyzed patien...

Background: Patients with adrenal insufficiency (AI) require long-term glucocorticoid (GC) replacement therapy and generally show an increased prevalence of bone metabolism alterations. Only few data are available on bone safety of dual-release Hydrocortisone (DR-HC) therapy. Objective: To evaluate bone metabolism in primary AI (PAI) and secondary AI (SAI) during long-term therapy with DR-HC.Methods: We evaluated patients with AI o...

Objective: Tablet levothyroxine (L-T4) is the common used therapy for hypothyroidism. In order to assess a good compliance to the therapy, treated patients are monitored with the execution of annual thyroid hormonal test. The stability of TSH levels in hypothyroid patients (with no malabsorption issues), treated with liquid L-T4, compared to that of the patients treated with tablet L-T4, remained a poorly understood topic. This study has the purpose to deepen this issue.<p...

Objective: An enhancement of the response rate has been recently showed in patients with Graves’ ophthalmopathy (GO) treated with corticosteroids and mycophenolic acid. In GO, retro-orbital cells showed a cytokine-induced secretion of Th1 and Th2 chemokines. Since no data are present in literature about the effect of corticosteroids and mycophenolic acid on the chemokines secretion in GO orbital cells, we aim to deepen out this topic.Methods: We est...

Introduction: Acquired generalized lipodystrophies (AGL) are rare syndromes characterized by complete loss of subcutaneous adipose tissue and very low serum leptin levels. AGL are complicated by severe insulin resistance, diabetes mellitus, dyslipidemia and fatty liver. In most patients evidence exists of an autoimmune etiology.Case report: We herein describe the case of a Caucasian woman who was diagnosed with lipodistrophy at 5 years of age, when she b...

Introduction: Cryptorchidism, the most frequent congenital malformation in full-term male newborns, increases risk of infertility and testicular cancer. Most cases remain idiopathic but epidemiological and experimental studies have suggested the role of both genetic and environmental factors. Physiological testicular descent is regulated by two major Leydig cell hormones: Insulin-like peptide 3 (INSL3) and testosterone.Methods and results: From a prospec...

Background: Human toxicity of bisphenol-A (BPA), a weak estrogenic environmental endocrine disruptor widely used in plastics, babybottles, cans and dental sealants, is under investigation. Human pharmacokinetics involves a rapid inactivation by hepatic glucuronyl- or sulfoconjugation and renal clearance. Fetal or perinatal exposure in rodents is associated with programmed adult reproductive diseases. Human epidemiological studies remain scarce especially concerning testicular ...

Introduction: The antitumor activity of a novel cyclic amide, CLM94, with anti-VEGFR-2 and antiangiogenic activity, in primary anaplastic thyroid cancer (ATC) cells in vitro and in vivo, has been studied.Design and Methods: CLM94 was tested: i) in two human cell lines (HMVEC-d, dermal microvascular endothelial cells; 8305C, undifferentiated thyroid cancer) at 0.001–100 mcM; ii) in ATC cells at the concentrations of 10, 30, 50 mcM; iii)...

Background: Type 2 diabetes mellitus (T2DM) significantly impacts Health-Related Quality of Life (HRQoL) and sexual function. The aim of this study was to evaluate sex differences in HRQoL and sexual function in patients with T2DM.Methods: We performed an ancillary study of RECOGITO trial (REmodelling in Diabetic CardiOmyopathy: Gender Response to PDE5i InhibiTOrs - NCT01803828). All patients completed the 36-item-Short-Form Health Survey (SF-36), assess...

The risk of thyroid dysfunction induced by Interferon (IFN)-β1b therapy, in particular in patients having preexisting thyroid autoimmune disorders (AITD), is well known. We report a case of a 60-year-old female, with a 15-year history of euthyroid autoimmune thyroiditis and a 3-year history of Multiple Sclerosis (MS), in care for the evaluation of hyperthyroidism. The patient started a specific immunomodulant IFN-β1a therapy (30 μg/week) twenty months before the...