Endocrine Abstracts

Introduction: Clinical symptoms in craniopharyngioma have been repeatedly described in the literature, but few studies have addressed the issue of acute-onset symptoms in children or adults. Refinements of diagnostic procedures and altered scanning routines over the last two decades may in theory have affected patterns of clinical presentation.Objective: To study the clinical phenotype of patients with newly diagnosed craniopharyngioma, with focus on var...

The value of patient-reported outcomes in treatment efficacy assessment of thyroid disorders is of great importance. Recently, a new tool, Comprehensive Symptom Profile (CSP-ThSF22), has been developed to assess symptoms specific for patients with nontoxic goiters. We aimed to test practicability and sensitivity of CSP-ThSF22 in patients with euthyroid goiter undergoing thyroidectomy. A total of 78 patients with uninodular/multinodular euthyroid goiter were enrolled in this st...

The value of patient-reported outcomes in treatment efficacy assessment of thyroid disorders is of great importance. Recently, a new tool, Comprehensive Symptom Profile (CSP-ThHyperSF27), has been developed to assess symptoms specific for patients with toxic goiters. We aimed to test practicability and sensitivity of CSP-ThHyperSF27 in patients with diffuse/ multinodular toxic goiter undergoing thyroidectomy. A total of 42 patients with diffuse/multinodular toxic goiter were e...

Aim: The aim of the study was to present some epidemiological data about Graves’ ophthalmopathy in a tertiary centre.Material and method: The retrospective study included 98 patients with Graves’ disease associated with infiltrative ophthalmopathy, evaluated in our Department of Endocrinology in the period 2008–July 2010.The mean age of the group was 45.2±12.4 years, with a female/male ratio=84/14.<p class="...

Introduction: ‘PreDiabetes’ was considered as a categories of increased risk for diabetes on the last ADA recommendations in 2010. The proposed diagnostic criteria include an HbA1c value between 5.7 and 6.4%, impaired fasting glucose (IFG) (100–125 mg/dl) and impaired glucose tolerance (IGT) levels (2-h values in the oral glucose tolerance test (OGTT) of 140 to 199 mg/dl). The HbA1c as new diagnostic criteria may actually increase the number of patients diagnose...

RET proto-oncogene is activated in the development of PTC via RET/PTC rearrangements. Single nucleotide polymorphisms (SNPs) of the gene are associated with PTC in some studies. We investigated possible association of SNPs with RET/PTC in Czech patients. We analyzed 234 patients with PTC (101 fresh frozen thyroid samples, 133 paraffin-embedded formalin-fixed samples) and 172 controls. RNA from frozen samples was reversely transcribed to cDNA. RET/PTC</i...

Aim of the study: The paper presents some clinical and laboratory parameters reflecting activity and severity of Graves ophtalmopathy (GO) and discusses the correlation between them.Subjects and methods: The study included 25 GO cases, with mean age 47.7±11.2 years and a female/male ratio of 21/4. The patients were evaluated clinically, by assessment of thyroid status (TSH, FT3, FT4, thyrotropin receptor autoantibodies (TRAb)) ...

Objectives: There are some reports about association of autoimmune thyroid diseases with human T cell leukemia virus type I (HTLV-I) infection. The objective of this study was to estimate the seroprevalence rates of anti-thyroid antibodies in HTLV-I carriers and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients in Mashhad, north east of Iran, to determine any association between HTLV-I infection and Hashimoto’s thyroiditis (HT).<p class="abs...

Introduction: Obesity effects pituitary–thyroid axis resulting in elevated thyroid stimulating hormone (TSH) level. We studied the relation between body mass index (BMI) and TSH in euthyroid and subclinical hypothyroid obese children and compared serum TSH level among obese and overweight children.Methods: Fifty consecutive children (aged 2–18 years) presenting for obesity were studied. All cases with TSH >10, low T3/T4</sub...

Background/objectives: The aim of the study was to assess association between diabetes mellitus (DM) and arterial hypertension (AH) in patients with adrenal incidentaloma.Design and methods: One hundred and eleven consecutive patients with incidentally discovered adrenal tumours were included in the study. OGTT was done and 24 h urinary catecholamines were measured. Aldosterone and plasma renine activity (PRA) were determined, and 1 mg dexametasone test ...