Endocrine Abstracts

Background & Aims: The aims of transsphenoidal surgery (restoration/preservation of vision and amelioration of hormonal excess) are balanced against the risk of inducing new post-operative pituitary deficits. This study aims to assess the rate of new anterior hormonal deficits following transsphenoidal pituitary adenoma surgery in our centre and to assess whether the visibility of normal pituitary gland on pre-operative imaging predic...

Background: Alemtuzumab (ALTZ) is a humanised monoclonal anti-CD52 antibody used as effective treatment for relapsing/remitting multiple sclerosis (MS), causing panlymphopenia with subsequent lymphocyte repopulation. Unfortunately, around 40% of patients develop secondary humoral autoimmunity, mainly affecting the thyroid gland. Anti-thyrotropin-receptor (TSHR) autoantibodies (TRAb) can stimulate (TSAb), block (TBAb) or not affect (‘neutral’) TSHR function, with TSAb...

Background & Aims: The aims of transsphenoidal surgery (restoration/preservation of vision and amelioration of hormonal excess) are balanced against the risk of inducing new post-operative pituitary deficits. This study aims to assess the rate of new anterior hormonal deficits following transsphenoidal pituitary adenoma surgery in our centre and to assess whether the visibility of normal pituitary gland on pre-operative imaging predic...

Background: Alemtuzumab (ALTZ) is a humanised monoclonal anti-CD52 antibody used as effective treatment for relapsing/remitting multiple sclerosis (MS), causing panlymphopenia with subsequent lymphocyte repopulation. Unfortunately, around 40% of patients develop secondary humoral autoimmunity, mainly affecting the thyroid gland. Anti-thyrotropin-receptor (TSHR) autoantibodies (TRAb) can stimulate (TSAb), block (TBAb) or not affect (‘neutral’) TSHR function, with TSAb...

Objectives: Measurement of TSH-receptor antibodies (TRAb) in hyperthyroid, pregnant women is an important tool when distinguishing between the autoimmune Graves’ disease and the physiological gestational hyperthyroidism. Evidence to support a cut-off for TRAb in early pregnancy is needed along with information on the frequency and follow-up of TRAb-positive as opposed to TRAb-negative hyperthyroidism.Methods: Within the North Denmark Region Pregnanc...

Introduction: First-line treatment for congenital adrenal hyperplasia (CAH) is hydrocortisone1. When adequate control is not achieved, prednisolone (or its prodrug prednisone) are often used. However, there has been no formal comparison of disease control in CAH comparing prednis(ol)one vs hydrocortisone and patients are often on a glucocorticoid dose that exceeds the guideline recommended dose of hydrocortisone (≤25 mg/day)1,2. We report an interim...

Background: SSTR substypes are collectively expressed in the majority of NENs. However, SSTR subtype expression is not routinely assessed for clinical decision-making, including patients eligible for targeted radionucleotide therapy. Elucidating the landscape of SSTR subtypes in context of molecular profiles for low-grade (LG-) and high-grade NENs (HG-NENs) provides an opportunity to better tailor targeted therapy. Here, we leverage the ability of transcriptomics to predict NE...

Background: In patients affected with type 2 diabetes mellitus (T2DM) a high prevalence of hypogonadism has been reported, even if there is no consensus on its metabolic and cardiovascular implications, especially according to the type of hypogonadism. The aim of this observational study is to evaluate: (1) the prevalence of different types of hypogonadism in T2DM according to validated criteria from the EMAS study; (2) look for correlations of gonadal status with severity or ...

Background: Diabetic retinopathy is a common complication of diabetes mellitus and the leading cause of blindness in the working-age population in the developed world. Novel biomarkers are needed to improve the screening efficiency for the prevention and early treatment of this condition. Accumulation of advanced glycation end products (AGEs) is considered as one of pathogenetic pathways in development of diabetic complications. AGEs are formed in the process of non-enzymatic ...

Mice with isolated GH deficiency (IGHD) due to GHRH receptor mutations live longer than their normal siblings with an extended healthspan, i.e., the period of life free from disabilities. Human IGHD individuals due to a mutation in the GHRH receptor gene from Itabaianinha, Brazil, has a normal lifespan with an extended healthspan (1). Our hypothesis is that their aging is accompanied by a delayed cognitive decline. Accordingly, we used the Literacy Independent Cognitive Assess...