Endocrine Abstracts

Objective: To analysis the clinical pathological characteristics and 131I curative responses of familial differentiated thyroid cancer(FDTC) and sporadic differentiated thyroid cancer(SDTC).Methods: A total of 112 FDTC patients(79 females, 33males, age(41.3±15.6)) and 1000 SDTC (658 females, 342males, (44.2±13.9)) who underwent 131I therapy in Department of Nuclear Medicine in our hospital between January 2011 and July 2021 we...

Introduction: A suspected human carcinogen and antithyroid substance, ethylenethiourea (ETU), is produced during the metabolism of ethylenebisdithiocarbamates (EBDCs). These fungicides are sprayed from above or while wearing a backpack. Ethylenethiourea (ETU), a Type II B carcinogen, and antithyroid chemicals are produced when EBDCs are broken down.Objective: The objective of conducting this research was to compare the occurrence of thyroid problems amon...

Backgrounds: Preoperative diagnosis of parathyroid carcinoma (PC) is critical for the determination of the scope of surgical intervention. Nowadays, specific diagnostic markers for differentiation of PC and benign tumors are unknown, and less than half of patients with PC undergo necessary en bloc surgery.Aims: To develop the instrument for preoperative diagnosis of PC.Materials and methods: A multi-center retrospective study inclu...

Background: Abnormal thyroid autoimmunity is often experienced in thyroid clinic. Some of them are associated with hyperthyroidism (HY) or chronic thyoiditis (Hashimoto, HA). The abnormality, however, is observed not only in HY or HA, but nodular goiter (NOD), and seems to be associated with various factors; age, visiting periods, residence, ABO blood type or others. We analyzed long-term (more than 16 years) data of patients who live in northeast Japan, if there is any charac...

Objectives: Somatotropinomas can be divided into three subgroups based on their distinct DNA methylation profiles1, one matching sparsely granulated (SG) and the other two matching densely granulated phenotypes (DG-A and DG-B). Sparsely granulated adenomas show fibrous body formation on cytokeratin immunohistochemistry, compared to diffuse staining in densely granulated adenomas. Methylation1 and gene expression data were analysed to identify (i) differen...

Introduction: Although not directly inherited, genetics play a significant role in the chances of developing Type1 Diabetes (T1DM), yielding a risk of 2–40% depending on the first degree relative (FDR) affected. T1DM is a self-managed condition in which education and patient/carer engagement are key. We had noted cases of poor engagement and glycaemic control in our patients with a FDR with T1DM but found a paucity of literature examining this relationship.<p class="a...

Introduction: Ultrasound is the main diagnostic tool for imaging pathology of the thyroid gland. The TI-RADS classification allows the evaluation of a risk of malignancy in the case of thyroid nodules, indicating the need to perform a puncture for a histological study. Bethesda system classifies them according to the cytological malignancy risk. Bethesda category 3 (B3) comprises ‘follicular lesion of undetermined significance’ or ‘atypia of undetermined signifi...

Background: DNA methylation has been recognized as a putative regulatory mechanism for CYP11B2 in primary hyperaldosteronism. We aimed to investigate the DNA methylation and the expression of a panel of genes encoding several enzymes involved in steroidogenesis in adrenocortical benign tumors.Methods: We collected a total of 60 adrenocortical tissues, including 9 non-functioning adrenal adenomas, 9 adenomas associated with autonomous cortisol se...

Background and Aims: Type 1 diabetes mellitus (T1DM) is caused by an autoimmune destruction of pancreatic beta cells, which renders patients insulin-dependent for life. The disease arises from a complex interaction among several genetic and environmental factors. To date, single nucleotide polymorphisms (SNPs) in >50 genes have been associated with T1DM, with HLA class II SNPs having the greatest impact on disease susceptibility. Other loci have minor effects on T...

Objective: Phenotypic variability and lack of genotype-phenotype correlations still represent a major challenge in the surveillance of patients carrying germline MEN1 (Multiple Endocrine Neoplasia type 1) mutations. MEN1 associated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are highly penetrant and show an indolent course. However, they are still the leading cause of death in MEN1 syndrome. Some single-center and national studies reported higher prevalence of GEP-...