Endocrine Abstracts

Progression of the diabetic peripheral neuropathy (DPN) demonstrated differences in the individual considered the contribution of genetic predisposition. We aim to study the relationship between the −866G/A polymorphism in the promoter region of the uncoupling protein 2 (UCP2) which enhances transcriptional activity and A allele frequency with nerve conduction velocities (NCV) and clinical factors. We compared 370 type 2 diabetic patients with healthy control. Subjective...

Cortisol dynamics have been found to be disturbed in acute illness. Despite reports on neuroendocrine disturbances after aneurysmal subarachnoid hemorrhage (SAH), data on cortisol dynamics in the acute phase of this illness are lacking. We evaluated diurnal cortisol rhythm in n=25 patients 1 week (t1) and 2–3 weeks (t2) after SAH. The study was approved by the local ethics committee. Cortisol and CBG were measured in serum, blood samples were drawn a...

Introduction: Obesity has been associated with increased androgenicity in women, however there are conflicting data on this subject. Objectives: To determine whether any androgen is independently related to body mass index (BMI), waist-to-hip ratio (WHR) or age. To access if there is an association between elevated plasma androgen levels and the presence of either morbid obesity or metabolic syndrome (MS).Design and Methods: A total of 148 obese women we...

1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) influences the differentiation and cytokine secretion of various immune cell types. These immune modulating effects of 1,25(OH)2D3 are mediated through the nuclear vitamin D receptor (VDR). In the immune system, the 1,25(OH)2D3/VDR complex interacts with promoter vitamin D responsive elements (VDRE), or interferes with the signalling of other transcription factor...

Background: Surgically treated patients with NFA often present with secondary hypogonadism. Hypogonadism is a well known risk factor for osteopenia or osteoporosis. The aim of this study was to assess (a) the frequency of osteopenia/osteoporosis in a single centre Swiss cohort of patients with operated NFA and (b) whether gender or hypogonadism impacts on bone density at follow up.Methods: Data of patients with NFAs diagnosed between 1967 and 2005 were a...

Transsphenoidal surgery is the most efficient primary treatment for acromegaly. However, some patients do not meet remission criteria after operation. Mixed growth hormone (GH)/prolactin (PRL)-secreting pituitary adenomas are known to predict poor surgical outcome. The aim of our study was to evaluate immunohistochemical markers in pure GH-and mixed GH/PRL-containing tumors and to investigate their prognostic value. In our study we included 39 acromegalic patients, who underwe...

The empty sella syndrome (ESS) is caused by the herniation of the suprarahnoidian space into the sella turcica, generating the compression of the pituitary gland and, in most cases, a remodelling of the sella. The purpose of this study was to evaluate the etiology, the degree of hormonal deficit and the occurrence rate of the signs and symptoms accompanying ESS.Material and methods: We performed a descriptive, retrospective study by analysing the medical...

A retrospective cohort study was undertaken using a reproductive health survey of 25 girls aged 14–27 years (Me 20,5 (16;23)) born to bromocriptine-treated mothers. The control group consisted of 25 women born after spontaneous pregnancy of the same age, mother age, region of residence. They were all seen in the clinic for health and psychological interviews (Multiscale Personality Assessment Test- MMPI). All of them were blood analysed for LG, FSG, prolactin, TSH, anti-T...

Preantral follicle development in polycystic ovaries (PCO) is characterised by an increased proportion of early growing follicles. We have previously shown that IGF-1 stimulates initiation of follicle growth in normal and PCO (Endocrine Abstracts 2004 7 P172). Here we have extended these studies, specifically to examine whether the ovulatory status of the patients from whom tissue is obtained influences the response to IGF-1. Small ovarian biopsies were obtained (with ethical ...

Objective: Interleukin-6 (IL-6) is an immunoregulative proinflammatory cytokine with pleiotropic functions. It was reported that plasma level of IL-6 in type 1 diabetes mellitus (T1DM) patients was higher than in healthy individuals. IL-6 is supposed to take part in pancreatic beta-cells destruction. So, we considered IL-6 gene to be a candidate one for T1DM. The aim of present study was to investigate the role of IL-6 gene promoter polymorphism in T1DM developme...