Endocrine Abstracts

Introduction: Sheehan syndrome has been for a long time the most frequent cause of hypopituitarism among women in developing countries, including Tunisia. Apart from hormonal deficits caused by SS, young women with SS are exposed to an increased risk of cardiovascular mortality. In this study, we aimed to evaluate the cardiovascular risk in patients with SS. Patients and methods This is a descriptive cross-sectional study. It was carried out in the Endocrinology department of ...

Background: Glycated albumin (GA) and glycated haemoglobin (HbA1c) measurements have been used to track the long-term glycemic management of diabetic patients. Other than glycemia, there are known influences on both glycated proteins. In obese, non-diabetic children, GA levels have been found to be low, while in adult diabetic patients, GA levels have been found to be adversely correlated with body mass index (BMI). The causes of the link between obesity and GA are still unkno...

Optimal in-patient glycaemic control improves morbidity and mortality in in-patients with diabetes1. The National Inpatient Diabetes Audit (NaDIA) is an annual snapshot audit of diabetes inpatient care in England and in Wales. We performed a similar audit in Our Lady of Lourdes Hospital, Drogheda (OLOLHD, 363 in-patient beds) on 26/01/2022 and 08/10/2020. Data from all adult in-patients with diabetes were gathered using a standard proforma. Data from the OLOLHD 2022...

Background: Benign adrenal tumours (AT) can be non-functioning (NFAT) or associated with cortisol excess, as indicated by failure to suppress serum morning cortisol to <50 nmol/l in the 1mg-dexamethasone suppression test (1 mg-DST). The latter group divides into patients with clinically overt signs of cortisol excess (adrenal Cushing’s syndrome, CUSH) and patients lacking CUSH signs (mild autonomous cortisol excess, MACE). Smaller series and a recent meta-analysis rep...

Primary hyperparathyroidism (PHP), usually due to multigland hyperplasia, occurs in >90% of patients with multiple endocrine neoplasia type 1 (MEN1). The literature is divided on the optimal surgical management for such patients. We report a retrospective cohort study on the long-term outcomes associated with limited, subtotal, or total parathyroidectomy as initial surgery for PHP in MEN1. The primary endpoint was recurrent PHP defined as an adjusted serum calcium >2.6 mmol/l ...

Objectives: Somatotropinomas form three subgroups with distinct methylation profiles1, one matching the sparsely granulated (SG) and the other two matching the densely granulated phenotypes (DG-A and DG-B). Publicly accessible raw methylation data1 and our RNA microarray data were analysed to identify differentially methylated regions (DMRs) and enriched genes between SG, DG-A and DG-B and normal anterior pituitary gland (NP), genes showing differential m...

Background and aims: Diabetic retinopathy (DR) is an important chronic complication of diabetes mellitus (DM), and is the leading cause of new cases of blindness in adults. Although several single nucleotide polymorphisms (SNPs) have been associated with DR, more information is needed to unravel the genetics of this complex disease. MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate expression of at least 60% of all protein-coding genes. A number of miRNAs ha...

Background: Cultural/psychological/spiritual/social factors influence quality-of-life (QOL) of population with diabetes [PWD]. We correlated spiritual well-being, religiosity, QOL, depression, and end-of-life despair in terminally ill PWD. We also explored stigmatized-issue of sexual-desire of PWD.Aim: Evaluate spirituality and its relation to depression and the QOL. Analyze impact of anxiety/mental-fatigue due to DIABETIES-diagnosis on sexuality/desire....

Introduction: Thyroid nodules are very common in the general population (20–75% ultrasound). There are clinical management criteria established by international societies and standardized cytological diagnostic criteria (Bethesda). However, there is still uncertainty in the management of category 3 (follicular lesion of undetermined significance). Objectives: To evaluate the clinical attitude to the cytological diagnosis of Bethesda category 3 (B3) in thyroid fine-needle ...

Introduction: At present patients and relatives garner more knowledge through website rather than direct interaction with the Consultant physician. We aimed at assessing whether Indian website about Endocrine Surgery matched with their counterpart abroad.Materials and methods: We identified two most searched Endocrine Surgery website world wide and 10 endocrine surgerywebsite maintained by trained Endocrine Surgeons (three years training leading to award...