Endocrine Abstracts

Background: There is currently no effective blood biomarker for lung neuroendocrine neoplasia diagnosis and management. We describe the clinical utility of a 51 neuroendocrine-specific gene expression set in blood to diagnose bronchopulmonary neuroendocrine tumors (BPNETs) and define their clinical status.Methods: The discovery set included BPNETs (n=154) and controls (n=90), randomly assigned (1:1) to a test and validation set. Specifi...

Introduction: Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing syndrome. It is characterized by the development of supracentimetric nodules resulting in increased adrenal volume and weight. Its presentation is clinically, radiologically and biologically heterogeneous. Morphological descriptions of PBMAH are rare. Although the initial description highlights that multinodular hyperplastic adrenal glands are made of a majority...

Objective: Pituitary apoplexy (PA) is a rare, sometimes life-threatening clinical syndrome. However, some cases are subclinical (SPA), just revealed by MR performed during the follow-up of known pituitary adenomas or due to other conditions. Our aims were to describe the clinical characteristics and evolution of the patients with SPA compared with patients with acute PA (APA). We also compare the results of surgery vs conservative management in the APA group.<p class="abst...

Objectives: 1.-Characterization of patients with tall cell variant papillary thyroid carcinoma (TCV-PTC) at diagnosis (Dx) compared to patients with classic papillary thyroid carcinoma (c-PTC);2.-Evaluation of response to therapy (RT) in the (TCV-PTC) cohortExperimental design: Retrospective observational studyMaterials and methods: Patients submitted to surgery for PTC in our institution since 2010 were eval...

Introduction: Vitamin D deficiency is associated with higher risk of severe COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (around 80.0% with plasma calcifediol <30 ng/ml) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown and the following winter in Northern Gran Canaria. There is an increasing awareness of this problem, both in family physicians and the general population, and t...

Background: Diagnostic work-up for Cushing ’s syndrome (CS) can be challenging, with variable performance characteristics on screening tests. We were recently referred a young female patient with Cushing’s disease (CD) due to a microadenoma. She presented with a seizure and initial biochemical work-up included a Synacthen stimulation test (SST). Her peak cortisol rose to over 1,000 nmol/l. Exaggerated response during SST is expected in hyperestrogenic states due to e...

Background: In 2014 a new Italian classification system of thyroid cytology divided the indeterminate TIR3 category in two groups, TIR3A and TIR3B, aiming to reduce unnecessary thyroidectomies. The reported risk of malignancy is: TIR3A: <10%, suggesting follow-up and possible FNA repetition after 6 months, and TIR3B: 15-30%, recommending surgery.Objectives: We aimed to: evaluate the histological prevalence of malignancy in TIR3A and TIR3B nodules in ...

Background: Obesity is a serious health problem worldwide and is caused by a wide variety of etiologies. There are several hormones which have been proved to be associated with increased body weight and has a direct effect on the fat metabolism like thyroid hormones.Methods: This is a case control study which included 384 adult persons, they were divided into 2 groups according to the thyroid function status, the first group included 204 apparently healt...

Introduction: Thyroid nodules are very common in the general population (20-75% ultrasound). There are clinical management criteria established by international societies and standardized cytological diagnostic criteria (Bethesda). However, there is still uncertainty in the management of category 5.Objectives: To evaluate the clinical attitude to the cytological diagnosis of Bethesda category 5 (B5) in thyroid fine-needle aspiration cytology (FNA). And s...

Material-Method: We registered from February 26, 2020 until January 23, 2022 (almost 2 years) patients with chronic autoimmune thyroiditis Hashimoto. Usual parameters for this disease were investigated: age, sex, ATPO, FT4, TSH, ultrasound pattern, antibody evolution, immune associations, lost pregnancies, other clinical associations (alergies, breast cancer). Patients were divided into 2 groups: those who had covid-19 (C-19) vs. those who did not have viral disease (<u...