Endocrine Abstracts

Aim: Recent reports of adverse skin reactions in patients receiving dipeptidyl peptidase-4 (DPP-4) inhibitors have increased awareness towards skin-targeting side effects. Bullous pemphigoid (BP) is an autoimmune blistering dermatosis with significant morbidity and mortality. We report the development of BP in patients with type 2 diabetes mellitus (T2DM) treated with DPP-4 inhibitors.Method: Evaluation of the temporal distribution of the frequency of BP...

Objectives: The rarity of pituitary apoplexy renders it a difficult subject for audit; hence there are no evidence-based standards of optimum care for such patients. The main controversy in management relates to the role of acute surgical intervention. Recently, a more conservative management has been adopted towards patients presenting with this condition. Therefore, it is important to evaluate the differences in outcome between patients submitted to surgical and conservative...

Objective: To evaluate the role of thyroid blod flow assessment by color-flow Doppler ultrasonography in the differential diagnosis of thyrotoxicosis in an outpatient endocrinology clinic.Material and methods: Consecutive patients with thyrotoxicosis presenting to our center between January–December 2013 were included in the study. Clinical date were collected and measurements of TSH, serum free thyroxine and TSH receptor antibodies were performed. ...

Introduction: Graves’ disease (GD) is an autoimmune disorder of the thyroid gland, which is characterisied by a breakdown in immune tolerance. The lymphocytic infiltration of the thyroid leads to production of autioantibodies targeting thyroid stimulating hormone receptor (TSHR). The clinical course of GD varies among patients and it is difficult to predict the relapse risk after antithyroid therapy withdrawal. It is believed that GD occurs due to genetic suspectibility ...

The cortisol secretion level of adrenocortical adenomas range from hormonally silent to overt hypercortisolism. The mechanisms leading to the autonomous hypersecretion of cortisol are unknown. The aim was to identify the gene expression alterations associated with the autonomous and excessive cortisol secretion of adrenocortical adenomas.Methods: The transcriptome of 22 unilateral adrenocortical adenomas (5 non-secreting, 6 subclinical cortisol-producing...

Objective: Relationship between pre-pregnancy BMI (PPBMI) in gestational diabetic (GD) patients, and age, country of origin, family history of type 2 diabetes mellitus (T2DM), GD history, and BMI after pregnancy.Methods: Transversal, descriptive study of 259 consecutive pregnant with confirmed DG. Analysis were based on Fisher’s exact test and Student’s t-test. A P<0.05 was significant (SPSS 19.0).Re...

Introduction: Abnormalities in cell cycle pathways, such as CDKN1B (p27) underexpression, have been identified in the pathogenesis of pituitary adenomas, but their underlying mechanisms have not been elucidated. Ribosomal proteins have been recently related to pituitary tumorigenesis. In gastric cancer, RPS13 down-regulates p27 and promotes cell cycle progression; these mechanisms have not yet been explored in pituitary adenomas.Objective: To evaluate th...

Introduction: Activating somatic mutation of the BRAF gene (V600E) has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (32–87%) in various races by different methods.In this study, we report the genetic analysis of BRAF mutation in a Korean cohort of 211 PTC by peptide nucleic acid clamp real-time PCR.Methods: PNA clamp real-time PCR was applied for BRAF analysis ...

Introduction: In the United Kingdom, the prevalence of type 1 diabetes in the under-15s is rising fast, an increase of 80% is expected by 2020 and even higher, 125%, in the under five age group. The National Service Framework Standard recommends that all children/young adults with diabetes should receive consistently high quality care and they, with their families, be supported to optimise the control of their blood glucose and all aspects of their subsequent development.<...

Introduction: Pituitary adenomas are benign neoplasms which grow slowly, but that can recur even after apparent radical resection. Until now, markers predicting regrowth and invasiveness have not been completely characterized.Design: We investigated cell proliferation and apoptosis parameters in 20 radically resected pituitary macroadenomas (six GH, two PRL, two ACTH, one FSH and nine non-secreting), in order to predict recurrence risk. Tumour regrowth w...