Endocrine Abstracts

Introduction: Central pontine myelinolysis (CPM) is a rare and potentially life-threatening complication of a sudden rise in serum osmolality. Along with extrapontine myelinolysis, it is part of the osmotic demyelination syndrome (ODS). Known risk factors include severe hyponatremia, alcoholism, thiazide use, hypokalemia, and malnourishment.Case report: We report the case of a 31-year-old-male with history of alcohol and cannabis dependence, who had atte...

Introduction: To determine the risk of recurrence in DTC, different clinical factors have been used (presence of adenopathies, extrathyroid extension, histology\..). The objective was to examine whether the value of early postoperative Tg concentration may also predict long-term recurrence of DTC.Material and Methods: The study included 249 consecutive patients (78.3% women, mean age 50.72 ± 14.26 years) with DTC who were initially treated by total ...

Introduction: For the clinical diagnosis of heterozygous familial hypercholesterolemia (HeFH) validated algorithms are used, with the Dutch Lipid Clinic Network (DLCN) Criteria being the most recommended in our environment. One of the items that scores for the system proposed by the DLCN is the value of LDL cholesterol. However, LDLc levels can be distorted by lipoprotein a (Lpa(a)) levels.Objective: To analyze the change in the validity of the DLCN crit...

Introduction: Angiomyolipomas are rare mesenchymal tumours arising from the perivascular epithelioid cells. They are benign endocrinologically inactive tumours with a histological structure consisting of variable amounts of adipose, thick-walled blood vessels and smooth muscle cells. Commonly, angiomyolipomas occur in the kidney with few extra renal case reports in adrenals.Case Report: We report the case of a 76-year-old-man with personal history of hyp...

Background and aims: Transition of patients with type 1 diabetes (DM1) from pediatric to adult care is challenging and international guidelines recommend effective transition programs. The aim of this study is to describe our baseline situation, without a structured transition program, and to identify factors associated with worse glycemic outcome.Materials and Methods: This is an observational, retrospective study of patients with DM1, aged 14 or more o...

Background: Current therapies for reducing raised intracranial pressure (ICP) in conditions such as idiopathic intracranial hypertension have limited efficacy and tolerability. As such, there is a pressing need to identify novel drugs. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat diabetes and promote weight loss but have also been shown to affect fluid homeostasis in the kidney. Here, we investigate whether exendin-4, a GLP-1R agonist, is able to modula...

Background: Current therapies for reducing raised intracranial pressure (ICP) in conditions such as idiopathic intracranial hypertension have limited efficacy and tolerability. As such, there is a pressing need to identify novel drugs. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat diabetes and promote weight loss but have also been shown to affect fluid homeostasis in the kidney. Here, we investigate whether exendin-4, a GLP-1R agonist, is able to modula...

Objectives: To evaluate the prevalence of eating disorders (ED) at an Endocrinology outpatient clinic (EOC); with the use of Bulimia Investigatory Test of Edinburgh (BITE).Methods: Descriptive analysis of clinical characteristics and BITE scores from patients with suspicion of ED at a first appointment in an EOC with an average of 128 new patients/year. Data was collected from January-2021 to December-2022. The main suspicion criteria were: self-reported...

Central pontine myelinolysis (CPM) is a neurological disorder typically caused by rapid correction of severe chronic hyponatremia. Conditions causing a hyperosmolar state can also cause CPM, but it is rarely seen in diabetes. We report the case of a 33-year-old woman with personal history of Type 1 Diabetes since she was 9 years old with very poor metabolic control (A1hbC 15%) and microvascular complications, who attended the emergency department due to left hemicranial headac...

Introduction: Grave’s disease (GD) is an autoimmune disease characterized by the development of thyroid-stimulating hormone (TSH) receptor antibodies that have a stimulating effect on the thyroid gland. There is a rare but non-incidental and well-documented association between GD and thymic hyperplasia (TH). Nonetheless, this association is often underdiagnosed in routine clinical practice and the mechanisms behind this association have yet to be thoroughly elucidated. Th...