Endocrine Abstracts

Anosmin-1, a protein defective in X-linked Kallmann's syndrome (X-KS), presents a structure comprising a cysteine rich N terminus (CR), a whey acid protein (WAP) domain followed by four fibronectin-like III domains (FnIII); and its function is heparan sulphate (HS) dependent. However, anosmin-1 and HS binding affinity is unknown. Although the WAP domain belongs to a protein family demonstrating serine protease inhibitory activity, the interacting serine protease remains to be ...

Introduction: Denosumab reduces bone resorption, increases BMD, and reduces fracture risk. Denosumab discontinuation (DD) induces an increase of B-crosslaps above baseline values for two years, and a decrease of BMD values. This rebound effect is associated with spontaneous clinical vertebral fractures (SCVF) in close to 15% of patients considering a follow-up of 2 years without taking another osteoporosis treatment. Prescribing a bisphosphonate or SERMs at DD would prevent th...

Acute lung injury (ALI) is characterized by endothelial and epithelial damage, followed by inflammatory. Glucagon-like peptide-1 (GLP-1) is a gut-produced hormone with insulinotropic effects. GLP-1 receptor is expressed in the lung, and there implicated in the synthesis of surfactant proteins. We have previously shown that liraglutide (LIR), a GLP-1 receptor agonist, restores surfactant protein-B (SPB) levels, a limiting factor for survival, and also angiotensin converting enz...

Food restriction (FR) of mothers during the perinatal period, can lead to disorders in emotional behaviors at offspring. GLP-1 may play a role in the regulation of anxiety-like behavior in rodents. The aim of this study was to asses if Liraglutide (a GLP-1 receptor agonist; LIR) given to pregnant rats may prevent the deleterious effects of FR in the anxiety-like behavior in pups at 21 days and two months of age males.Twenty-five pregnant Sprague-Dawley r...

Aim: To know if Tg levels after treatment (total thyroidectomy and radioiodine ablation) in the DTC can predict their prognosis in the long term.Material and methods: Basal Tg and Tg after rh-TSH were measured in 229 patients with DTC without any evidence of residual tumour (negative neck ultrasonography) after treatment. The group was followed until tumour recurrence or, if recurrence was not found, a minimum of 12 month (mean ± SD =63±37 mont...

Introduction and objective: The pregnancies in women with pregestational diabetes are associated with increased risk of abortion, birth defects, complications of pregnancy and perinatal morbidity and mortality. Pregnancy planning would be associated with better metabolic control, and therefore better obstetric and perinatal outcomes. The objetive of this study has been to evaluate the obstetric results of women with pregestacional type 1 diabetes and compare planned with not p...

67 y/o old female, with long history of hyperthyroidism, without treatment and hypertension. Two months prior to admission, she received amiodarone 200 mg daily due to cardiac arrhythmia. One week prior to admission, she developed symptoms of Congestive Heart Failure and weight loss. Family history: hyperthyroidism in two sisters. Physical examination: acutely ill, thin female, in moderate respiratory distress. Alert, oriented x 3.BP: 155/119 mmHg HR: 150.Prominent findings: m...

Background: Cardiovascular disease (CVD) is the leading cause of death in persons with type 1 diabetes (T1DM). However, there are no CVD-risk prediction models for this population in widespread use and those developed from general population and type 2 diabetes have been shown to underestimate CVD-risk in T1DM. Recently, the Steno Type 1 Risk Engine (ST1RE) was developed for predicting CVD in a cohort of T1DM persons without clinical CVD. We investigate the relationship betwee...

Adrenal insufficiency is a common complication of transsphenoidal surgery (TSS) for pituitary adenoma. It is very important to identify patients requiring glucocorticoid replacement, minimising risks of adrenal insufficiency.Aim: To assess the performance of early (3° day) post-TSS 08:00 a.m. cortisol measurement to detect and exclude secondary adrenal insufficiency.Methods: We selected patients undergoing TSS in our hospital ...

Transforming growth factor β1 has a critical role in the regulation of testicular function. Transgenic male mice over expressing α and β subunits of hCG (hCG+) are infertile and testicular steroidogenesis is enhanced showing high levels of testosterone and progesterone (P4). The chronic hCG hyperstimulation leads to Leydig cell (LC) hypertrophy/hyperplasia in prepubertal mice.Aims: To analyze: i) the expression of the TGF-β...