Endocrine Abstracts

Aim: To determine, in type 1 diabetes mellitus (T1DM) patients, if there is any relationship between the age at onset and the number of HLA risk alleles for T1DM (DRB1*03 and DRB1*04).Methods: Retrospective study. We selected patients with T1DM diagnosis (pancreatic autoimmunity and insulin-dependent diabetes) and age at onset >15 years, identifying 275 subjects (59.6% men and 40.4% women), with a median age at onset of 31 years (interquartile range ...

Intestinal nutrient sensing and transport are gaining increasing attention in the field of obesity research. To date, in vitro studies in this area have largely used two dimensional (2D) cell culture models. However, 2D cell cultures are limited by a lack of cellular heterogeneity, behaviour, and communication observed in vivo. There has consequently been growing interest for the application of three-dimensional (3D) cell culture ...

Intestinal nutrient sensing and transport are gaining increasing attention in the field of obesity research. To date, in vitro studies in this area have largely used two dimensional (2D) cell culture models. However, 2D cell cultures are limited by a lack of cellular heterogeneity, behaviour, and communication observed in vivo. There has consequently been growing interest for the application of three-dimensional (3D) cell culture ...

Background: Immune checkpoint inhibitors (ICIs) including programmed-death cell-1 (PD-1), programmed death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) re-activate T lymphocytes and promote cancer cell death. Immune-related adverse events (irAEs) are common in cancer patients receiving ICIs. Endocrine irAEs include primary thyroid dysfunction, hypophysitis, type 1 diabetes mellitus (T1DM) and primary adrenal insufficiency. These endocrinopathies may require a...

Post-surgical hypoparathyroidism occurs as inadvertent removal or irreversible damageparathyroid disease, irreversible or permanent causing decreased action of parathormone leading to hypocalcemia and hypophosphatemia.Clinical Case: A 52-year-old woman referred from our outpatient clinics due to severe hypocalcemia symptomatic; hand and foot cramps, and hyperphosphatemia: albumincorrected calcium. (5.52 mg/dl and phosphate of 6.6 mg/dl). She presents a h...

Introduction: Thyroid cancer is the most common endocrine malignancy, and its incidence is increasing worldwide.Objective: Our aim is to look at the prevalence of ultrasound features and FNA findings of nodules in patients operated on for thyroid cancer in our hospital.Material and methods: Cross-sectional observational study of patients operated on for thyroid cancer at the Regional University Hospital between 2018-2021, we collec...

Introduction: Hypercalcemia of malignancy usually appears in patients with osteolytic metastasis and in those patients with humoral hypercalcemia due to secretion of PTHrp by the tumor. Hypercalcemia due to calcitriol production by the tumor is uncommon (<1% of cases of hypercalcemia of malignancy). It is the cause of virtually all cases of hypercalcemia in patients with Hodgkin’s lymphoma and approximately one third of cases in non-Hodgkin’s lymphoma. It has als...

Introduction: The differential diagnosis of cystic cervical masses includes thyroid cyst, thymic cyst, thyroglossal duct cyst, branchial cleft cyst, bronchogenic cyst, lymphangioma and parathyroid cyst (PC). PC is one of the less common causes of the cervical masses.Methods: We report the case of a 37-year-old man admitted to the hospital with a neck mass of 48 mm.Results: Our patient presented with neck pain and an hipoechogenic n...

Introduction: Lymphocytic hypophysitis is a strange cause of hypopituitarism which can represent a difficult diagnostic and therapeutic challenge.Objectives and methods: Describe the diagnosis, evolution and treatment of a case of lymphocytic hypophysitis in a patient who began with hypopituitarism and a year after the diagnosis had local symptoms. We reviewed the medical history of the patient from the moment the patient contacted with us to the months ...

Aim: To investigate the frequency of thyroid carcinoma and its subtypes in one region over three decades.Material and methods: Data retrospectively collected from a tissue bank where all hospitals in a region with a little above 1 million inhabitants should send samples from all operated tumors, from 1981 to 2010.Results: From 1981 to 1990 there where 156 thyroid cancers; 206 from 1991 through 2000 and 362 from 2001 through 2010, w...