Searchable abstracts of presentations at key conferences in endocrinology

ea0049eje1biog | The European Journal of Endocrinology Prize Lecture | ECE2017

European Journal of Endocrinology Prize Winner

The European Journal of Endocrinology Prize is awarded to a candidate who has contributed significantly to the advancement of knowledge in the field of endocrinology through publication. This year’s recipient is Dr Miguel Lopez who will receive his prize and deliver his lecture as part of the ECE 2017 Opening Ceremony on Saturday 20 May 2017. Further information on the prize can be found at http://www.ese-hormones.org...

ea0044ec1.2 | Early Career Symposium: Launching your career whatever it may be | SFEBES2016

A career in professions allied to science and medicine

Cabrera-Sharp Victoria

It’s crowded at the top of the academic pyramid. A large percentage of doctoral graduates and research staff will not gain tenure in academic research positions. Universities now provide career advice for graduate students and post-doctoral researchers, usually regarding careers outside of academia, be that in research or otherwise. What, then, for those of us that are still passionate about science and working within academia? A career in science administration may not b...

ea0044ec1.5 | Early Career Symposium: Launching your career whatever it may be | SFEBES2016

Rejection from Tesco: Making your PhD work

Mirczuk Samantha

We all work incredibly hard to produce a thesis that will allow us to sail through our vivas and get that piece of paper, which says we have a doctorate. The next step is to grab hold of an exciting post-doc position, where we can press the “start” button on a rather traditional career path to independence. During the course of two post-docs, the golden numbers of research articles will be written, submitted, peer-reviewed and published, allowing for a fellowship app...

ea0043oc20 | Design a Clinical Program for Success | WCTD2016

Selected adipokines in patients with type 2 diabetes: relationship to markers of vascular damage

Karasek David , Gajdova Jaromira , Kubickova Veronika , Cibickova Lubica , Krystynik Ondrej , Vaverkova Helena

Introduction: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF-21), C1q/TNF-related protein 9 (CTRP9) and allograft inflammatory factor-1 (AIF-1) belong to the proteins produced by adipocyte tissue, which differently contribute to oxidative stress, chronic inflammation, insulin resistance and endothelial damage. The aim of this pilot study was to compare their levels in patients with diabetes and in healthy individuals and determine ...

ea0042p6 | (1) | Androgens2016

The bi-directional interaction of AR and IL6 signalling in the response to enzalutamide in prostate cancer cells

Handle Florian , Erb Holger HH , Luef Birgit , Hoefer Julia , Dietrich Dimo , Parson Walther , Kristiansen Glen , Santer Frederic R , Culig Zoran

Chronic inflammation and high expression of pro-inflammatory cytokines, such as Interleukin-6 (IL6), are well-known risk factors for prostate cancer (PCa). IL6 is known to activate the androgen receptor (AR) and has been implicated in development of castration resistance. Therefore, we wanted to investigate the interaction of AR and IL6 signalling and the effect on anti-androgen treatment. We could confirm IL6 mediated activation of the AR on 3 AR target genes in presence of R...

ea0037s4.3 | Thyroid hormone and cardiovascular system | ECE2015

Cardiovascular actions of novel Thyroid Hormone metabolites

Hofig Carolin

Thyroid hormone (TH) is one of the key players in modulating cardiovascular function. The hormone increases heart rate and force of contraction by modulating cardiac gene expression, thereby providing a molecular explanation for the clinical correlation between hyperthyroidism and cardiovascular mortality. The talk will present current aspects of cardiovascular function mediated by newly discovered TH metabolites. Recent studies have shown that a single injection of 3-iodo-<sm...

ea0037s7.1 | Novel mechanisms of central weight regulation | ECE2015

Nutritional regulation of hypothalamic inflammation

Chowen Julie A

Hypothalamic inflammation has been the focus of an increasing number of studies in recent years as it is thought to underlie the pathogenesis of obesity-associated insulin resistance and type 2 diabetes. These studies have also highlighted the role of glial cells in metabolic control, due to the fact that both microglia and astrocytes are involved in central inflammatory processes. High fat diet (HFD)-induced obesity has been the most commonly used model for the analysis of th...

ea0037s19.1 | Metabolic dysfunction in PCOS | ECE2015

Genetic determinants of metabolic dysfunction in PCOS

Strauss Jerome , McAllister Jan

PCOS is a common disorder that is reported to affect 5–7% of women of reproductive age. Although there has been debate about the diagnostic criteria for PCOS, hyperandrogenemia/hyperandrogenism, not explained by other causes, is a hallmark of the disorder, and it is included as an essential element in all ‘consensus’ diagnostic schemes. Studies on cultures of human theca cells derived from normal and PCOS women have demonstrated that PCOS theca secretes greater ...

ea0037s26.2 | Towards the bionic pancreas: will the journey end? | ECE2015

Continuous glucose monitoring systems

Battelino Tadej

Good metabolic control depends on the information of blood glucose concentration, routinely obtained with self-monitoring of blood glucose (SMBG). More frequent SMBG is associated with improved metabolic control. In the last decade, real-time continuous glucose monitoring (CGM) of subcutaneous glucose concentration became routinely available and is now introduced into day-to-day management helping people with diabetes make informed decisions on dosing, eating and engaging in p...

ea0037s28.2 | Hormones and immunity in pregnancy | ECE2015

Sex hormones and B cells in pregnancy

Jensen Federico

Mammalian pregnancy is characterized by tremendous changes and adaptations in the endocrine as well as in the immune system. Early in pregnancy, levels of female sex hormones, progesterone (P4) and estradiol (E2) produced by the corpora lutea (CL) significantly rise, promoting huge modifications of the uterine epithelium ensuring embryo implantation. Once the embryo is implanted, trophoblast cells produce and release increasing levels of human chorionic g...