Searchable abstracts of presentations at key conferences in endocrinology

ea0056cet1biog | Clinical Endocrinology Trust Lecture | ECE2018

Clinical Endocrinology Trust Lecture

The Clinical Endocrinology Trust (CET) Award is given for clinical research that addresses aspects of endocrinology at the forefront of clinical practice. This year’s recipient is Professor Philippe Chanson who will receive his prize and give his lecture as part of the European Congress of Endocrinology (ECE), beginning on the 19 May 2018. The award is sponsored by the Clinical Endocrinology Trust and further information can be found at <a href="https://www.ese-hormones.o...

ea0094p154 | Nursing Practice | SFEBES2023

Improving collaboration between endocrine patient support groups and the society for endocrinology

Breen Louise , Smith Vick , Okoro Grace , Turner Helen

Background: Patient Support Groups (PSG) play a key role in the support, education, research and training for patients and clinicians alike, as well as providing invaluable input to key documents e.g. Defining the Future of Endocrinology (DfE), highlighting the importance of a closer working relationship with SfE.About the PSG Network: Established in Sept 2021, the network includes representation from SfE affiliated PSG ...

ea0081ep258 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of mimic-mir-21/au@ nanosystem on browning activation: a possible therapeutic tool against obesity

Lhamyani Said , Gentile Adriana-Mariel , Giraldez Perez Rosa Maria , Grueso Elia , Mengual Mesa Maria , Estepa Enrique , Olveira Gabriel , Tinahones Francisco-Jose , Bekay Rajaa El

Background and aim: Obesity is a chronic disease associated with a positive energy balance leading to lipotoxicity, which contributes to the onset of obesity-associated metabolic disorders such as type 2 diabetes and insulin resistance. It’s well known that thermogenesis in brown adipose tissue (BAT) and “browning” of white AT (WAT) increase energy expenditure, thus promoting weight loss and protect against obesity. Recently, the microRNAs (miRNAs) that regulate...

ea0090p70 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Association between advanced glycation end products (AGEs) and diabetic retinopathy in Latvia

Svikle Zane , Peterfelde Beate , Petersone Dace , Nagobade Renate , Janceva Julija , Valeinis Janis , Baumane Kristine , Sokolovska Jelizaveta

Background: Diabetic retinopathy is a common complication of diabetes mellitus and the leading cause of blindness in the working-age population in the developed world. Novel biomarkers are needed to improve the screening efficiency for the prevention and early treatment of this condition. Accumulation of advanced glycation end products (AGEs) is considered as one of pathogenetic pathways in development of diabetic complications. AGEs are formed in the process of non-enzymatic ...

ea0090p641 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Cancer, cardiovascular disease and all-cause mortality in Iraqi- and Swedish-born individuals in Sweden - the MEDIM cohort study

Fadhel Dhaher Nadine , Pikkemaat Miriam , Shaat Nael , Nilsson Anton , Bennet Louise

Background: Immigrants from the Middle East to Sweden have a twice as high prevalence of type 2 diabetes (T2D) and obesity as native-born Swedes. Both obesity and T2D have been linked to increased incidence of cancer, cardiovascular disease (CVD) and all-cause mortality (ACM); however, data on differences between ethnicities are scarce. Aims: In a population-based cohort we aimed to study the impact of Middle Eastern and European ethnicity on ACM, cancer...

ea0067o34 | Oral Presentations | EYES2019

Splicing machinery is dysregulated in pituitary neuroendocrine tumors (PitNETs) and associated with aggressiveness features

Jimenez-Vacas Juan M , Vazquez-Borrego Mari C , Fuentes-Fayos Antonio C , Venegas-Moreno Eva , Gadelha Monica R , Galvez-Moreno Maria A , Soto-Moreno Alfonso , Gahete Manuel D , Castano Justo P , Luque Raul M

Objective and methods: Recent studies suggest that altered alternative splicing and, consequently, appearance of an abnormal splicing pattern and even of aberrant/oncogenic splicing-variants, represent a common molecular feature of most tumor pathologies, including Pituitary Neuroendocrine Tumors (PitNETs). However, the putative alteration, pathophysiological role and potential therapeutic utility of splicing machinery components [i.e. spliceosome-components (SCs) and splicing...

ea0063gp91 | Thyroid Nodules and Cancer | ECE2019

Detection of EIF1AX, CHEK2 and PPM1D gene variants in thyroid carcinomas

Dvorakova Sarka , Pekova Barbora , Sykorova Vlasta , Vacinova Gabriela , Vaclavikova Eliska , Moravcova Jitka , Katra Rami , Vlcek Petr , Sykorova Pavla , Plzak Jan , Bavor Petr , Kodetova Daniela , Chovanec Martin , Vcelak Josef , Bendlova Bela

Objectives: The identification of novel causing genes in thyroid carcinoma is very important in diagnosis and prognosis of the disease. Recently, The Cancer Genome Atlas (TCGA) study found EIF1AX, CHEK2 and PPM1D genes as new minor causing genes in the papillary thyroid cancer (PTC) development. The goal of this study was to detect variants in these genes in PTC, follicular thyroid carcinoma (FTC) and anaplastic thyroid carcinoma (ATC) cohorts.<p class="a...

ea0063p896 | Diabetes, Obesity and Metabolism 3 | ECE2019

NME7 gene is associated with the shape of glucose curves during oral glucose tolerance test

Bendlova Běla , Vejražkova Daniela , Šedova Lucie , Šeda Ondrej , Včelak Josef , Vaňkova Marketa

Introduction: The shape of the glucose curve during oral glucose tolerance test (OGTT) reflects the dynamic of the glucose stimulus-response, and it can be considered as predictor of the impaired glucose tolerance and Type 2 Diabetes (T2D). Nucleoside diphosphate kinase 7, non-metastatic cells 7 (NME7) is an acknowledged member of ciliome and is involved in the biogenesis or function of cilia. Due to the fact that obesity and T2D are common in several ciliopathies, we enrolled...

ea0063p1022 | Interdisciplinary Endocrinology 2 | ECE2019

Influence of type 2 diabetes on androgen levels in women with Alzheimer’s disease

Vaňkova Marketa , Vacinova Gabriela , Hill Martin , Včelak Josef , Vejražkova Daniela , Bendlova Běla

Introduction: Alzheimer’s disease (AD) is a neurodegenerative disease that is manifested by progressive loss of cognitive function. Neuroactive steroids and their metabolites have an important regulatory role in the nervous system, affect neuronal plasticity, response to stress, learning and memory and have a neuroprotective effect. One of the not fully elucidated risk factors for AD is impaired glucose tolerance/type 2 diabetes (T2D). It is well known that lower androgen...

ea0042il6 | Hormone and Disease | Androgens2016

Androgens and cardiovascular diseases

Maggi Mario

Observational studies have consistently shown a relationship between low testosterone (T) and a higher cardiovascular (CV) risk profile. However, it is still obscure whether reduced T levels in the elderly play a direct pathogenetic role in the stratification of CV risk, or if CV diseases (CVD) and low T are concomitant conditions, both associated with the aging process. Much evidence supports both of these possibilities. In the meanwhile, recent reports in the scientific and ...