Searchable abstracts of presentations at key conferences in endocrinology

ea0014p526 | (1) | ECE2007

Laterality in the supraspinal innervation of the adrenal gland: a dual-virus tracer study

Tóth Ida , Wiesel Ory , Tóth Dorina , Boldogkoi Zsolt , Bálint Kamill , Gerendai Ida

Recent studies using the viral transneuronal tracing technique allowed to reveal brain neurons synaptically connected with the adrenal gland, via specific infections within functionally related chains of neurons. The aim of the present study was to investigate whether cerebral neurons involved in the innervation of the adrenal gland exhibit asymmetry or not. In order to label simultaneously the supraspinal neurons connected with the right- and left-sided adrenal glands, dual-v...

ea0014p615 | (1) | ECE2007

Retinol-binding protein-4 in polycystic ovary synrome - relationship with obesity and androgen levels

Vrbikova Jana , Hill Martin , Bendlova Bela , Grimmichova Tereza , Dvorakova Katerina , Vondra Karel

Aim and background: Retinol binding protein 4 (RBP 4) is an adipocyte-secreted molecule causing insulin resistance in transgenic animals. RBP was increased in subjects with impaired glucose tolerance and diabetes type 2. The levels of RBP-4 in PCOS were not investigated till now.Subjects and methods16 lean PCOS (BMI 21.4 (1.75) kg/m2, age 24.1 (4.1) years), 25 obese PCOS (BMI 30.3 (4.8) kg/m2, age 26.3 (5.0) years) and 13 healthy wo...

ea0013p272 | Steroids | SFEBES2007

A central physiological role for attenuated circulating DHEAS levels in aged female Rhesus Macaques?

Urbanski Henryk , Lemos Dario , Sitzmann Brandon , Garyfallou Vasilios , Kohama Steven

In humans and rhesus monkeys (Macaca mulatta) the zona reticularis of the adrenal gland produces large amounts of dehydoepiandrosterone (DHEA) and its sulfated form, DHEAS. The circulating levels of these steroids are particularly high during early adulthood, and they then decline gradually during aging, especially in females. To help elucidate the physiological function of this steroidal loss we examined the 24-hour plasma profiles of DHEAS in female rhesus monkeys, us...

ea0011p429 | Endocrine disruptors | ECE2006

The UV filter benzophenone 2 inactivates human recombinant thyroperoxidase in vitro and disturbs thyroid hormone homeostasis in rats

Schmutzler C , Bacinski A , Ambrugger P , Klammer H , Wuttke W , Grüters A , Jarry H , Köhrle J

UV filters are produced in high amounts for multiple uses. Their main application is in sun lotions for skin protection against accelerated ageing or cancer, but they are also found in many other cosmetics or in plastic materials to prevent their radiation-induced damage. Regardless of these protective properties, UV filters seem to interfere with both the reproductive and the thyroid endocrine axis. We here screened for effects of the UV filter benzophenone 2 (BP2) on thyroid...

ea0009s35 | Symposium 9: Regulation of ovarian folliculogenesis | BES2005

Dialogue between oocytes and somatic cells

Eppig J

There are two populations of GCs in large antral follicles: mural granulosa cells (MGCs) that line the ovarian follicle wall, and cumulus cells (CCs) closely associated with the oocyte. Among the genes expressed more highly in CCs was one encoding an amino acid transporter (Slc38a3). Slc38a3 mRNA was not detected in oocytes. Expression of Slc38a3 mRNA was reduced in the CCs after removal of the oocyte and restored by co-culturing CCs with fully-grown oocyt...

ea0008s3biog | Society for Endocrinology Medal | SFE2004

Society for Endocrinology Medal Lecture

Eastell R

Richard Eastell, Bone Metabolism Group, University of Sheffield, Sheffield, UK AbstractProfessor Eastell is Professor of Bone Metabolism at the University of Sheffield where he is also Director of Research for Medicine. He is the Research Dean for the School of Medicine and Biomedical Sciences, and Deputy Director of the Division of Clinical Sciences (North) at the University of Sheffield. He is also the Director for R...

ea0008s8 | Zonation of the adrenal cortex�molecular signalling | SFE2004

Paracrine regulation of the adrenal cortex

Vaudry H , Contesse V , Lefebvre H , Lenglet S , Sicard F , Gallo-Payet N , Yon L , Delarue C

There is now clear evidence that diverse corticotropic factors released by chromaffin cells, by nerve fibers innervating the adrenal cortex, by cells of the immune system and/or by the endothelium are involved in the local control of adrenocortical cell activity. The adrenal gland of lower vertebrates, notably amphibians, in which cortical and chromaffin cells are closely entangled, is a very suitable model to investigate the paracrine regulation of adrenocortical cells. The e...

ea0008oc16 | Neuroendocrinology and Reproduction | SFE2004

Sp1 and CREB promote nectin-2 transcription to regulate adherens junctions assembly in the testis

Lui WY , Sze KL , Lee WM

Nectin-2, a major protein component of the adherens junctions (AJs), is found between Sertoli cells and germ cells in the seminiferious epithelium. Recent studies have shown that the expression of nectin-2 gene in testis is crucial to maintain normal spermatogenesis since male knockout mice lacking nectin-2 gene are sterile and possess morphological abnormal spermatozoa. However, the molecular mechanisms governing its basal transcription remain poorly understood. By the use of...

ea0007s49 | How to compete for grant funding | BES2004

Experience with applications for fellowships

Bicknell A

Fellowships are grants made available to researchers to support both the costs of the research and the salary of the applicant. Fellowship schemes are available from the Research Councils, the Wellcome Trust, the Royal Society and several other charities. Although awards are available to researchers with established positions to allow them to be relieved of their teaching/admin duties, most awards are designed to promote the careers of postdoctoral scientists. The awards are m...

ea0056gh1biog | The Geoffrey Harris Prize Lecture | ECE2018

The Geoffrey Harris Prize Lecture

The prestigious Geoffrey Harris Prize is awarded to an established researcher in the field of neuroendocrinology and is the first of its kind in Europe. This years recipient is Professor Christos S. Mantzoros, who will receive his prize and deliver his lecture as part of the ECE 2018 Opening Ceremony on Saturday 19 May 2018. Further information on the prize can be found at https://www.ese-hormones.org/grants-and-...