Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0003p91 | Diabetes & Metabolism | BES2002

Thioland and steriod levels in polycystic ovary syndrome

Dvorakova K , Tallova J , Hill M , Vrbikova J

Aim: To investigate total homocysteine (Hcy), cysteine (Cys), glutathione (GSH), lipid and steroid sulfate levels in women with polycystic ovary syndrome (PCOS).Methods: The blood levels of Hcy, Cys, GSH (determined by HPLC), total and HDL-cholesterol, insulin (IRMA),DHEA and DHEAS, cortisol, pregnenolone, 17-hydroxy-pregnenolone and pregnenolone-sulphate (all RIA) were examined in 44 women with PCOS (age 24+/-7yrs) and 12 healthy controls (34+/-5yrs) in...
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ea0056ehm1biog | European Hormone Medal Lecture | ECE2018

European Hormone Medal Lecture

The European Hormone Medal is awarded to an international scientist who has made significant contributions to the field of basic or clinical endocrinology. This year’s recipient is Professor Ilpo Huhtaniemi who will receive his prize and give his lecture as part of the European Congress of Endocrinology (ECE), beginning on the 19 May 2018. Further information on the prize can be found at https://www.ese-horm...
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ea0073ep98 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Novel toxicological method to investigate the increased ROS in mouse kidney stem cell mitochondria by doxorubicin

Lee Minsu , Jeong Sunhwa , Lee Jimin , Yi Donglin , Eui-Bae Jeung

Mitochondria play a key role in hormone biosynthesis and involve in renal cell proliferation by producing about 90% of cellular energy and controlling cell apoptosis. Doxorubicin is commonly used for many tumor treatments. However, its clinical utility is limited by the adverse reactions, which are known to be nephrotoxic. The mechanism by which doxorubicin induced kidney damage is still not completely understood, however nephrotoxicity by doxorubicin might be related to mitoc...
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ea0037ep798 | Pituitary: clinical | ECE2015

Increased serum levels of the Wnt antagonist Dicckopf-1 (DKK1) and impaired trabecular bone mineral density using QCT scan in acromegalic patients

Valassi Elena , Crespo Iris , Aulinas Anna , Urgell Eulalia , Malouf Jorge , Llauger Jaume , Marin Ana Maria , Biagetti Betina , Webb Susan M

Introduction: Acromegaly is associated with increased bone turnover and skeletal fragility. Although the GH/IGF1 system plays an important role in bone homeostasis, effects of GH excess on the Wnt signalling pathway are to be determined. Bone quantitative CT (QCT) provides a volumetric, tridimensional measure of bone mass at the trabecular and cortical level.Aim: i) To compare volumetric bone density (vBMD) using QCT in patients with acromegaly vs gender...
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ea0037ep959 | Thyroid (non-cancer) | ECE2015

Difficulties in the interpretation of urinary iodine excretion in pregnant women

Szanto Zsuzsanna , Csiszer Attila , Croitorescu Zsuzsanna , Kun Imre Zoltan

Introduction: The urinary iodine excretion (UIE) from fasting morning urine sample is a good epidemiologic indicator for iodine state, used in populational groups (schoolchildren, pregnant women) at risk to develop iodine deficiency disorders. It is not adequate to evaluate individual iodine intake. In pregnant women, especially with chronic autoimmune thyroiditis, it is important to estimate iodine state.Objectives: To evaluate the individual iodine sta...
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ea0031p192 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Augurin stimulates food intake in male Wistar rats

Patterson Michael , Tadross John , Suzuki Keisuke , Beale Kylie , Boughton Charoltte , Ghatei Mohammad , Bloom Stephen

Augurin is a putative neuropeptide product of the esophageal cancer-related gene-4. We have previously demonstrated intra-cerebroventricular (ICV) and intra-paraventricular nucleus (iPVN) administration of augurin (71–148) stimulates the hypothalamo-pituitary-adrenal axis in male Wistar rats. This effect was dependent on the release of CRH. Since CRH is known to inhibit feeding, we hypothesised augurin (71–148) would have similar actions. We therefore investigated th...
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ea0028p170 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

The effect of specific micronutrients on appetite

Greenwood Hannah , McGavigan Anne , Ghatei Mohammad , Bloom Stephen , Murphy Kevin

Ingested protein has a greater satiating effect than other macronutrients. The underlying mechanism is unknown, but it has been shown that protein induces greater increases in anorectic gut hormone levels than carbohydrate or fat. It was hypothesised that these effects could be mediated by specific amino acids comprising the protein. We therefore examined the effects of specific amino acids on food intake and gut hormone release. Fasted male Wistar rats received an oral gavage...
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ea0025pl3biog | Society for Endocrinology Transatlantic Medal Lecture | SFEBES2011

Society for Endocrinology Transatlantic Medal Lecture

Kopchick J J

J J Kopchick, Ohio University, Athens, Ohio, USA. AbstractDr John J Kopchick is an internationally recognized leader in the growth hormone (GH) field. Since 1987, he has held the Milton and Lawrence H Goll Eminent Scholar Professorship in Molecular and Cellular Biology and directs the Growth/Obesity/Diabetes Section of the Edison Biotechnology Institute at Ohio University in Athens, Ohio. He also is Professor in the B...
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ea0054is3 | (1) | NuclearReceptors2018

Nuclear receptors, transcriptional enhancers, and gene regulation

Franco Hector L , Murakami Shino , Hou Tim Y , Vasquez Yasmin M , Liu Ziying , Nagari Anusha , Malladi Venkat S , Nandu Tulip , Kraus W Lee

Transcriptional enhancers, which function as nucleation sites for the assembly of transcription-regulating complexes across the genome, drive cell type-specific patterns of gene expression that underlie the distinct biological properties of different cell types. Although many features of active enhancers (e.g., H3K4me1, H3K27ac, enrichment of p300/CBP and Mediator, and enhancer RNA production) have been defined by genomic assays, the roles of these features in ERα enhance...
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ea0051oc7.5 | Oral Communications 7 | BSPED2017

Service satisfaction, mental wellbeing and clinical progression in young people with diabetes in transition from child to adult services

Gray Sue , Cheetham Tim , Parr Jeremy , Mann Kay , Pearce Mark , McConachie Helen , Colver Allan

Introduction: Transition from child to adult healthcare is a period of vulnerability for young people with diabetes. We hypothesised that patient satisfaction with services and patient wellbeing would be positively associated with a satisfactory clinical progression.Methods: We included data from 150 young people recruited in 2012 to a longitudinal study of transition (http:research.ncl.ac.uk/transition). Young people’s satisfaction with services (&...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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