Endocrine Abstracts

Background: Obstructive sleep apnoea syndrome (OSAS) is common; disproportionately affecting the overweight and obese. Continuous positive airway pressure (CPAP) is the first-line treatment for moderate to severe OSAS. Clinical equipoise exists as to whether CPAP treatment directly affects pituitary-gonadal hormone synthesis.Study Aim: This study aimed to determine the effect of CPAP treatment on gonadotropins, prolactin, sex-hormone binding-globulin (SH...

Introduction and background: Diabetes Mellites is a complex metabolic disorder characterized by chronic hyperglycaemia. Celiac disease & T1DM are immune-mediated diseases that share common susceptibility factors notably HLA genetics. AITD and T1DM are two common autoimmune diseases that can occur concomitantly. It has been proposed that a complex genetic basis together with multiple nongenetic factors make a variable contribution to the pathogenesis of T1DM and AITD. NICE ...

Goal: Decrease a number of lower limb amputations in PDM in Uzbekistan by improvement of specialised help given to patients with DFS.Materials and methods: Prior to 2010 there were only 2 ‘Diabetic foot’ rooms in Tashkent, Uzbekistan. In 2010–2012, CPA ‘UMID’ jointly with Uzbekistan Ministry of Health and Research Centre for Endocrinology implemented a project ‘Prevention of lower limb amputations in people with diabetes mel...

Goal: Decrease a number of lower limb amputations in PDM in Uzbekistan by improvement of specialised help given to patients with DFS.Materials and methods: Prior to 2010 there were only 2 ‘Diabetic foot’ rooms in Tashkent, Uzbekistan. In 2010–2012, ‘UMID’ association jointly with Uzbekistan Ministry of Health and Research Centre for Endocrinology implemented a project ‘Prevention of lower limb amputations in people with diab...

Goal: To study a frequency of occurrence and factors of progressive diabetic retinopathy (DR) in people with DM type 2 in Uzbekistan.Materials and study methods: Within the framework of WDF project ‘Prevention of blindness in people with diabetes mellitus in Uzbekistan’ granted to ‘UMID’ association in 2008, we carried out DR screening in people with DM type 2 in three pilot regions of Ferghana, Bukhara areas and the Republic of Karak...

Introduction: Neonatal hypoglycaemia (NH) is common in infants born soon after betamethasone administration, and may be reduced by at-target peri-partum glycaemic control. A Pregnancy-specific Intravenous Insulin-Glucose Infusion (PIIGI) protocol was introduced at a tertiary hospital in June 2017, replacing a generic Adult IntraVenous Insulin protocol (AIVI) not designed for pregnancy, without change in indication for IV insulin (initiated with any BGL>6.7 mmol/L following...

Frederic Jaisser, MD, PhD has a permanent position as Director of Research at the National Institute of Health and Medical Research (INSERM) from 1996. Dr Jaisser received his medical training and degrees from the Reims Medical School and qualified as Nephrologist in 1990. In 2003, he joined the Collège de France in Paris as part of an independent INSERM team and is currently the director of a team of the INSERM ...

Background: Obesity contributes to the occurrence of many metabolic and cardiovascular complications including Type 2 diabetes, hypertension etc. Body adiposity is not just an energy store, but also an endocrine organ with elaboration of hormones and cytokines. Some of these cytokines have been implicated in the initiation and propagation of inflammation, and hence atherosclerosis.Aim: This study examined the relationship between high-sensitivity C-react...

Introduction: Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism results in thermolabile, reduced functioning enzyme and predicts hyperhomocisteinemia and altered DNA methylation. On the other hand, several studies indicated a higher plasma homocysteine (Hcy) levels in patients with primary hypothyroidism than in healthy, euthyroid individuals, including some experimental studies that indicated decreased MTHFR activity in hypothyroid patients. We cond...

Introduction: Although education is widely regarded as one of the pillars of diabetes treatment, it is relatively little work analysing its effectiveness. Therefore we would like to present our prospective observations.Method: In 2003–2004, 500 consecutive patients visiting our diabetes education centre put to the test the knowledge of diabetes as 20 questions which focus on practical skills proceedings in diabetes. We did not have a direct affect t...