Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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Page 4 of about 168 results

ea0015p330 | Steroids | SFEBES2008

Salivary cortisol: a possible regulator of salivary annexin 1

Renshaw Derek , Mancini Lucia , Flower Rod , Perretti Mauro

Several hormones, including cortisol, have a circadian rhythm in plasma and saliva. Salivary cortisol is now extensively used for screening and following patients with various conditions where the regulation of hypothalamo–pituitary–adrenal axis is abnormal, for example in major depression where salivary cortisol levels show a disruption or loss of circadian rhythm. Annexin 1 is a glucocorticoid-induced protein, which is responsible for mediating several anti-inflamm...
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ea0011oc40 | Neuroendocrinology and neoplasia | ECE2006

Expression of IGF-I & IGF-IR in tamoxifen sensitive and tamoxifen resistant breast cancer

McVittie CJ , Khalaf S , Ogunkolade W , Carpenter R , Bustin SA , Jenkins PJ

Background: The growth hormone/ IGF-I axis is important in the pathogenesis of breast cancer and increased IGF-I signalling through the IGF-I receptor (IGF-IR) has been implicated in the development of tamoxifen resistance in breast cancer.Aims: To compare mRNA and protein expression of IGF-I & IGF-IR in (i) wild type (WT) and tamoxifen resistant (TR) MCF-7 breast cancer cells and (ii) breast cancer tissue from women with primary and recurrent, tamox...
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ea0008p74 | Reproduction | SFE2004

Effect of gonadotrophin and insulin on the balance of sterol regulatory element-binding protein(SREBP) isoforms in human granulosa cells

Richardson MC , Cameron IT , Simonis CD , Das MC , Hodge TE , Zhang J , Byrne CD

Clinical insulin resistance, concomitant with higher circulating insulin, is implicated in the pathogenesis of polycystic ovary syndrome (PCOS) in which there is abnormal lipid metabolism with changes in ovarian hormone production. SREBPs are key transcriptional regulators of lipid biosynthesis and therefore may be involved in changes occurring in PCOS. We have examined whether insulin and gonadotrophin regulate SREBPs.Local ethical approval was granted ...
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ea0002p16 | Clinical case reports | SFE2001

MASSIVE CHILDHOOD OBESITY IN A PATIENT WITH KLYNEFELTER KARYOTYPE AND PRADDER-WILLY PHENOTYPE

Mendes P , Monteiro L , Cardoso M , Silva C , Santos M , Cunha C , Monteiro T , Ramos M

We report an 18-year-old boy referred to our outpatient clinic at 8 years and 11 months of age with a history of early-onset childhood hiperphagia, infantile central hipotonia and lethargy, mild mental retardation and emotional instability. His height was 125 cm, height SDS = -1 (target height = 169,5 cm, SDS = -0,78) and he weighted 40 Kg (BMI = 25,6;WFH =164%). He had small hands and feet, fat face with prominent forehead, bitemporal narrowing, triangular upper lip, microgna...
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ea0042p10 | (1) | Androgens2016

Metastases-prone localized prostate cancer: a genomic analysis

Van den Broeck Thomas , Gevaert Thomas , Prekovic Stefan , Boeckx Bram , Smeets Elien , Ong Kaye , Lehrer Jonathan , Haddad Zaid , Erho Nicholas , Helsen Christine , Lambrechts Diether , Buerki Christine , Davicioni Elai , Joniau Steven , Claessens Frank

Clinical features of the primary prostate tumor remain insufficient for clinicians to accurately define patients at highest risk of developing metastases. However, the primary tumor is the source of these metastases, and thus should contain information on its metastatic potential. We hypothesized that the combination of a primary tumor’s copy number alterations (CNAs) and genome-wide transcriptome information would give us more insight in the biology of metastases-prone l...
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ea0037ep119 | Steroids, development and paediatric endocrinology | ECE2015

Influence of food on daily profiles of steroids

Duskova Michaela , Racz Beata , Sramkova Monika , Hill Martin , Starka Luboslav

Introduction: Whereas the daily profiles of the main steroid hormones are well known, minor differences in the course of their levels related to defined and standardised food intake were studied rarely.Methods: Eight women (mean age 29.48±2.99 years, mean BMI 21.3±1.3 kg/m2) in follicular phase of menstrual cycle were examined. The levels of C-peptide, glucose, LH, FSH, SHBG, cortisol, testosterone, dihydrotestosterone, progesterone,...
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ea0070aep369 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Insulin regulated aminopeptidase (IRAP) inhibition affects glucose metabolism in obese pre-diabetic Zucker rats

Krskova Katarina , Balazova Lucia , Dobrocsyova Viktoria , Balogova Erika , Suski Maciej , Olszanecki Rafal , Zorad Stefan

Skeletal muscle and adipose tissue has been identified as an endocrine organ and their metabolism exerts an impact on whole-body metabolism. Endocrine functions attributed to adipokines and myokines are involved in body weight regulation and insulin sensitivity. Obesity is associated with dys-regulation of adipose tissue and skeletal muscle metabolism and is accompanied with insulin resistance. Our study investigates the effect of insulin regulated aminopeptidase (IRAP) inhibi...
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ea0009s55 | Young Endocrinologists Session | BES2005

Tricks for success in research: the clinic versus the lab

Crown A

If you are a clinician considering a first attempt at research, ask yourself some simple questions. Why? It must be because you want to, whether you are considering an academic or a clinical career. When? Post-MRCP is recommended. If you are considering an academic career, starting early will give you longer to develop your interests whilst you are still creative and original. Where and with whom? Aim for a centre of excellence, with a large research team rather than a lone re...
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ea0056eje1biog | The European Journal of Endocrinology Prize Lecture | ECE2018

The European Journal of Endocrinology Prize Lecture

The European Journal of Endocrinology Prize is awarded to a candidate who has contributed significantly to the advancement of knowledge in the field of endocrinology through publication. This year’s recipient is Professor Filip K. Knop who will receive his prize and deliver his lecture as part of the ECE 2018 Opening Ceremony on Saturday 19 May 2018. Further information on the prize can be found at https://w...
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ea0090ep629 | Endocrine-related Cancer | ECE2023

A retrospective study investigating the potential relationship between obesity and thyroid cancer

Flood John , Mohamed Sara

Thyroid cancer is the most common endocrine malignancy, and accounts for between 5 and 10% of thyroid nodules biopsied in endocrine services. As per the Global Cancer Observatory, the incidence of thyroid cancer in Bahrain is 2.12 cases per 100 000 people, which is less than the neighbouring countries of Saudi Arabia and Kuwait. The purpose of the study is to investigate the relationship between thyroid cancer and obesity in Bahrain, where 28.9% of males and 38.2% of females a...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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