Endocrine Abstracts

Objective: A mesenteric mass with surrounding mesenteric fibrosis (MF) is a hallmark of small intestinal neuroendocrine tumours (SI-NETs) and known to induce abdominal complications. However, little is known on the evolution over time and the pathways involved in progression. Our aim was to assess the development of the metastatic mesenteric mass over time and find predictors for progression.Methods: Retrospectively, 530 patients with proven SI-NET and &...

The ability of thyroid cells to specifically uptake radioiodine is frequently compromised in the neoplastic setting, particularly in older patients with poorly differentiated thyroid cancer and larger metastases, resulting in a 10-year survival rate of less than 10%. The mechanisms which govern cellular iodide uptake via the sodium iodide symporter (NIS) have been elucidated with increasing molecular clarity over the past 35 years. NIS is regulated in a tissue-specific manner,...

The first line treatment of somatotroph adenomas is pituitary surgery, that aims at removing the tumor, but which is frequently incomplete, as invasion into cavernous sinuses often limits the surgical resection. Multimodal medical treatment, which is burdensome, very expensive and has variable therapeutic efficacy, is currently required in more than 60% of the patients. New therapeutic approaches are therefore necessary for controlling hormone secretion, tumor development and ...

There is increasing evidence that alterations in alternative splicing can be linked to key tumor features in cancer. Dysregulations in the splicing machinery constitute the underlying cause in many of these alterations and, consequently, splicing and its control are emerging as a novel and transversal cancer hallmark, due to its association with different dysfunctions of tumor cells. In line with this, we discovered the existence of aberrantly spliced variants of somatostatin ...

Background: Postprandial hypoglycemia is an increasingly recognized complication after bariatric surgery. Its hallmark is a pronounced glycemic rise after carbohydrate ingestion followed by an exaggerated hyperinsulinemic response. Recent studies have shown that IL-1β contributes to postprandial stimulation of insulin. Furthermore, inhibition of SGLT2 reduces excessive plasma glucose increase. Therefore, we investigated whether inhibition of IL-1β with the IL-1 recep...

Dysregulation of the splicing machinery is emerging as a novel cancer hallmark due to its association with multiple dysfunctions in tumor cells. An inappropriate function of the components of this machinery (spliceosome) could be primarily linked with the generation of tumor-associated aberrant splicing variants. In line with this, we have previously reported that overexpression of aberrantly spliced variants of somatostatin receptor 5 (sst5TMD4) and ghrelin (In1-ghrelin) is d...

Introduction: Insulin resistance is a well-known hallmark of the metabolic syndrome (MetS), and it detrimentally affects also protein metabolism, favoring to the decline of lean body mass. The aim of the present study was to explore muscle strength (as a functional consequence of sarcopenic obesity) and muscle quality (namely, myosteatosis) in women with and without the Metabolic Syndrome (MetS).Methods: Study participants were enrolled at the Sapienza U...

Background: Follicles imaturation, as the hallmark of polycystic ovarian syndrome caused by prenatal androgen exposure, is suspected to be effected through expression changes of related genes. The aim of this study was to evaluate gene expression and promoter methylation of GATA6 and Follistatin (FST), two factors involved in follicle maturation, in adult female rats prenatally exposed to androgen excess by comparing them with non-treated rats.Material a...

Background: Thyroid cancer incidence is increasing, especially the cancers ≤1 cm (T1a). Previous evidence suggests underuse of FNA. Several international guidelines for the management of thyroid cancer have been published. Especially the year 2006 was a hallmark, with the publication of both the ETA consensus and ATA guidelines.Aim: Compare thyroid cancer subtypes and management before and after 2006.Methodology: Retrospectiv...

Metabolic reprogramming resulting in significant alterations of the energy metabolism is a hallmark of prostate cancer (PCa). In this study we performed a comprehensive metabolic analysis of various human (LNCaP, DuCaP, PC-3, Du145) and murine PCa cell lines differing in the expression of the tumor suppressor phosphatase and tensin homolog (PTEN). In line with previous studies we found that PTEN- PCa cells (LNCaP, PC-3) had a higher glycolytic activity than PTEN<sup...