Endocrine Abstracts

Markers of endothelial dysfunction, including soluble E-selectin (sE-selectin) are related to insulin resistance and are predictors of type 2 diabetes. Insulin resistance is associated with metabolic inflexibility, i.e. an impaired stimulation of carbohydrate oxidation and inhibition of lipid oxidation in insulin-stimulated conditions. The aim of the present study was to estimate the relationships of serum sE-selectin concentration with carbohydrate and lipid oxidation in lean...

Background: Obesity is associated with an increased risk of impaired glucose tolerance and type 2 diabetes. Insulin resistance is the link between obesity and disturbances of glucose metabolism. It is suggested that some substances secreted by adipose tissue might play a role in the pathogenesis of insulin resistance. One of these substances is interleukin-6 (IL-6), cytokine, which regulates synthesis of the acute-phase proteins in the liver. The aim of the present study was t...

Introduction: The molecular events involved in the formation of parathyroid adenomas are not well understood. Two genes, cyclin D1 (CCND1) and MEN-1, have been established as having major roles in parathyroid tumorigenesis. Tumor suppressor gene HRPT2 is frequently mutated in parathyroid carcinoma. The aim of our study was to analyze HRPT2 expression in parathyroid adenomas and in residual normal/atrophic parathyroid tissue and to relate it to other...

Aim of the study: Polycystic ovary syndrome (PCOS) is common disease affecting women in reproductive age which leads to anovulation. In pathogenesis of PCOS insulin resistance plays an important role. The aim of the present study was to look for possible relationship between interleukin 18 (IL-18) and insulin resistance in patients with PCOS.Material and Methods: The study was done in 76 patients with PCOS and 40 women without menstrual disturbances. The...

It is a well-known fact that vitamin D has an impact on many tissues of human body. Recent studies showed that vitamin D deficiency has an influence on inflamation indicators in several endocrine diseases (for example PCOS, graves disease). The aim of the study was to demonstrate correlation between 25-OH vitamin D concentration and chosen inflammation indicators (C-reactive protein and insulin) in patients with non-functioning adrenal incidentalomas. Seventy-one patients hosp...

Abstract: Up to 96% of changes detected in adrenal glands are non-functioning adrenal incidentalomas. Adrenal masses are associated with increased risk of metabolic syndrome (MS). Studies demonstrate that new anthropometric parameters can be useful indicators of disturbances in glucose and lipid metabolism in various diseases. The purpose of the study was to determine antropometric parameters and its relationship with MS factors according to the criteria of the International D...

Polycystic ovary syndrome is associated with lipid and carbohydrate metabolism disorders, leading to obesity and insulin resistance. The aim of the study was to asses the correlation among anthropometric parameters, metabolic markers (lipid and carbohydrate profiles) and CRP as inflammatory indicator in women with Polycystic Ovary Syndrome. The study consists of 43 women diagnosed with Polycystic Ovary Syndrome based on 2003 Rotterdam criteria. The patients were hospitalized i...

Polycystic Ovary Syndrome increases the risk of cardiovascular diseases. To factors predisposing to cardiovascular diseases belong: hypertension, lipid and carbohydrate profiles, smoking and reduced physical activity. The aim of this study was to determine the association between selected factors predisposing to cardiovascular diseases and anthropometric parameters and CRP concentration in women with Polycystic Ovary Syndrome. The study was conducted amongst 43 women, aged 18-...

The observed increase in the incidence of Hashimoto’s thyroiditis (HT) requires the research on environmental factors that may initiate or model its course. There have been reports of the impact of vitamin D3 deficiency on HT development.Objective: To assess the degree of deficiency of 25OHD3 and the relationship between the disease duration and 25OHD3 levels in patients with HT.Material and methods: 310 people were enrolled i...

Introduction: It is well known that DHEA and DHEA-S has and impact on lipid metabolism, cardiovascular system and others. De Castro et al. showed that cortisol/DHEA-S ratio was an independent predictor of long-term mortality in patients with sepsis. Chronic inflammation is an important factor in cardiovascular diseases development that reduce quality and life expectancy. CVDs are more common in patients with adrenal incidentaloma than in general population. Literature data on ...