Endocrine Abstracts

Introduction: Diagnosis of pheochromocytoma is rarely established in pregnancy, although can cause threat to health and life of foetus and mother. Exact and early diagnosis is crucial for effective treatment.Purpose: The purpose of our study is to present a case of patient with pheochromocytoma and medullary thyroid carcinoma (MCT) – MEN2A syndrome - diagnosed in 9-th week of pregnancy.Material and method: Twenty nine-year-old...

Polycystic ovary syndrome (PCOS) is heterogeneous disorder leading to infertility. The introduction of Rotterdam criteria creates different PCOS phenotypes, i.e. hyperandrogenic anovulatory with (A) and without (B) polycystic ovaries (PCO) morphology in ultrasonography (usg), hyperandrogenic ovulatory with PCO morphology in usg (C), non-hyperandrogenic anovulatory with PCO morphology in usg (D). In PCOS insulin resistance might be involved in the development of endocrine and m...

Fibroblast growth factor 21 (FGF21) might increase glucose uptake in adipocytes and reduce plasma glucose and triglycerides in animal models of diabetes. The aim of the present study was to assess serum FGF21 concentration in lean and obese subjects, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation. We examined 76 subjects with normal glucose tolerance, 36 lean (BMI <25 kg/m2) and 39 overweight or obese...

Polycystic ovary syndrome (PCOS) is a main cause of women infertility. There are data suggesting an increased risk for cardiovascular disease in PCOS. Insulin resistance might play a role in the pathogenesis of PCOS and its metabolic complications. The aim of the study was to asses the prevalence of The National Cholesterol Education Program (NCEP)-defined metabolic syndrome (MS) in women with PCOS in relation to insulin resistance and endothelial dysfunction – soluble E-...

Anorexia nervosa (AN) is an eating disorder, resulting in sustained low weight. In AN, similarly to syndromes of lipodystrophy, one observes the significant loss of the adipose tissue. In lipodystrophies, despite the lack of subcutaneous adipose tissue, insulin resistance is observed. Adipose tissue is known as a source of a variety of bioactive peptides, known as adipocytokines. The aim of the present study was to examine the plasma concentration of adipocytokines in relation...

Visfatin is a newly discovered protein secreted by adipose tissue, which is suggested to play a role in pathogenesis of insulin resistance. Polycystic ovary syndrome (PCOS) is heterogeneous disorder, where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. The aim of the present study was to asses the relation between serum visfatin and insulin sensitivity and markers of hyperandrogenism in a lean and obese PCOS patients. The stud...

The pathogenesis of insulin resistance is not completely understood, however, there are data that it might be associated with altered tissue carbohydrate and lipid oxidation. Adiponectin may be a key regulator of insulin sensitivity and energy metabolism. The aim of the present study was to determine the association of adiponectin, glucose metabolism (oxidation and storage) and lipid oxidation by applying the euglycemic clamp technique and indirect calorimetry.<p class="ab...

Adropin, hormone playing an important role in carbohydrates and lipids metabolism, improves mainly the glucose homeostasis. It could also play a protective role in pathogenesis and development of cardiovascular diseases. The purpose of the study was to assess the adropin concentration and some parameters of nutritional status (BMI, WHtR, BAI, VAI) as well as biochemical parameters (fasting glucose and insulin, and lipid profile). 25 patients (84% of group was women, n...

Visfatin (pre-B cell colonyenhancing factor) is a adipocytokine playing an important role in glucose homeostasis. High concentrations of visfatin are observed in obese people. Previous studies suggest that estimation of visfatin concentration could be a promising tool for predicting obesity or its metabolic consequences. The aim of the study was to evaluate the correlation between visfatin concentration, selected anthropometric parameters (BMI, WHR, BAI, VAI index) and biochem...

Introduction: In recent years the growing rate of newly diagnosed papillary tyroid cancers (PTC) has been observed. Nowadays most of PTC are small (mostly <2cm in diameter) with no unfavourable patomorphological features, although the cases of incompletely resected PTC can still be encountered. Incomplete tumour resection, regardless of the presence of microscopic (R1) or macroscopic (R2) disease, after operation, is considered as a high-risk factor for PTC recurrence/pers...