Endocrine Abstracts

Introduction: Adipocyte fatty acid binding protein (A-FABP) is mainly expressed in adipocytes, and circulating A-FABP has been associated with markers of obesity. Women with PCOS are at increased risk of developing abdominal obesity what could be related to serum concentration of A-FABP.Aim: The aim of the present study was to investigate the relationships between serum concentration of A-FABP and parameters of obesity e.g. waist to hip ratio (WHR) and t...

Introduction: Polycystic ovary syndrome (PCOS) is associated with an increased risk of abdominal obesity, what is regulated by numerous genetic, epigenetic, and environmental factors. MicroRNAs (miRNAs) are known regulators of gene expression, involved in the development of metabolic disturbances. Dual-energy X-ray absorptiometry (DXA) is an accurate method of body composition analysis. The aim of the present study was to investigate the association between circulating miRNAs,...

Introduction: The prevalence of obesity in elderly population increased. Obesity leads to increased morbidity and mortality as well as worsens quality of life in older individuals. Body-mass index (BMI) is the most widely used adiposity index. BMI correlates with body fatness but this index does not account for fat mass versus fat-free mass. Recently a new index of body adiposity the body adiposity index (BAI) was introduced. This novel index correlates well (in comparison to ...

Introduction: Type B insulin resistance syndrome is an autoimmune disorder characterized by the production of autoantibodies against the insulin receptor. It leads to glucose metabolism disorders, extreme insulin resistance, hyperandrogenism and is associated with other features of autoimmunity.Case report: A 27-year-old man, with a 2-years history of psoriasis, was admitted to our Department because of loss of weight (20 kg in 1 year) and fatigue. He al...

Introduction: In ATA recommendations (2016) a delayed risk stratification (DRS) system proposed by D.P. Momesso et al. was accepted as a diagnostic tool for the risk stratification of unfavorable clinical outcome and for monitoring the clinical outcome in differentiated thyroid cancer (DTC) patients treated without radioactive iodine (RAI).The aim of the study: To evaluate the DRS system in patients with low clinical stage (pT1aN0/Nx).<p class="abste...

Polycystic ovary syndrome (PCOS) and type 1 diabetes (T1DM) are accompanied by increased risk of atherosclerosis. A higher prevalence of PCOS in T1DM patients has been reported. Brachial artery flow-mediated dilatation (FMD) and intima media thickness of common carotid artery (IMT) are used to detect an early endothelial dysfunction.The aim of our study was to examine IMT and FMD in T1DM women with PCOS. We also estimated the relation of IMT and FMD to c...

Introduction: The prevalence of polycystic ovary syndrome (PCOS) is increased in women with type 1 diabetes (T1DM) in comparison to the general population. It has been suggested that exogenous insulin administered to T1DM women in supraphysiological doses could act as co-gonadotropin and lead to disturbances observed in PCOS.Aim: The aim of this study was to evaluate the phenotypic characteristic and differences between diabetic women with PCOS (T1DM+PCO...

Introduction: Brain derived neurotrophic factor (BDNF) is a neurotrophin which plays a role in neuronal growth and differentiation. Decreased level of BDNF is supposed to play a role in the pathogenesis of the neurodegenerative diseases. Recent data indicate that BDNF could be also involved in angiogenesis. Several lines of evidence support the role of BDNF in glucose metabolism. The decreased level of BDNF are observed in obesity and type 2 diabetes mellitus. Polycystic ovary...

Introduction: Polycystic ovary syndrome (PCOS) and type 1 diabetes (T1DM) are accompanied by an increased risk of cardiovascular complications. The higher prevalence of PCOS in T1DM was reported and thus T1DM women with PCOS exhibit a higher risk of cardiovascular diseases. Soluble E-selectin (sE-selectin) and intercellular adhesion cell molecule-1 (sICAM-1) are considered as an early markers of atherosclerosis.Aim: We aimed to evaluate plasma levels of ...

Introduction: Mechanism of pathogenesis of pituitary adenomas is still unknown. Gene expression differences in pituitary cells of different origin are not extensively described. Identification of genes specific for pituitary adenomas should enable better understanding of differences in their response to therapy, especially to radiotherapy.Aim: The aim of our study was to evaluate the correlation of coexpression of distinct pituitary adenoma genes based o...