Endocrine Abstracts

Background: Vitamin B12 (B12) deficiency results in disturbance of 1-carbon metabolites [methylmalonyl coenzyme A (MMA), homocysteine and S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM) and methionine] that collectively affect lipogenesis leading to risk of cardiovascular diseases. In clinical studies, B12 deficiency is associated with higher BMI and dyslipidaemia (high triglycerides and low HDL). The role of B12 in hepatic metabolism of...

Caveolin-1 (cav1) is a member of the thyroxisome multiprotein complex required for thyroid hormones synthesis which is decreased in Hashimoto’s thyroiditis (HT) and excessive in Graves’ disease (GD). Both pathologies are characterized by oxidative stress (OS), the production of reactive oxygen species (ROS) exceeding the antioxidant defenses. The aim of this study is to correlate cav1 expression and OS in HT and GD. Primary cultures of human thyrocytes were treated o...

Objectives: Human CD3+CD20+ T cells represents 3-5% of circulating T cells and may be detected in all lymphatic organs and in the cerebrospinal fluid. In healthy individuals CD3+CD20+ T cells have been shown to produce higher levels of IL-17A and/or IFN-γ than those of CD3+CD20- T cells. Some reports described the role of CD3+CD20+ T cells in autoimmune disorders such as multiple scler...

The presence and the role of CD20+ T cells in humans has been described in autoimmune disorders such as multiple sclerosis and rheumatoid arthritis. In healthy subjects, CD3+CD20+ T cells are detected in all lymphatic organs and in the cerebrospinal fluid and represent about 5% of circulating T cells. Some reports described their production of high levels of IL-17A and/or IFN-γ. This study was aimed at investigating the behavior of CD3<sup...

We report a case of small cell neuroendocrine carcinoma of laryngeal localization. The involvement of the larynx still exceptional. We present in this paper the radiological, pathological and therapeutic aspects of this tumor that was diagnosed in a 48-year-old man. A 59 years old male patient, chronic smoker, with 10 packs per year; without any particular medical history. he consulted for a rapidly progressive cervical swelling since one year, associated with dysphonia. The w...

Diagnostic work-up for Cushing Syndrome (CS) can be challenging and is based on clinical and biochemical assessment. Biochemical evidence of endogenous steroid excess is demonstrated through overnight dexamethasone suppression test (ODST), low dose dexamethasone suppression test and/or 24-hour urinary free cortisol estimation (UFC). Once endogenous steroid excess is confirmed, random serum ACTH measurement is key in determining the suspected source of steroid excess: ACTH-inde...

A 39-year-old lady with background history of autoimmune hypothyroidism diagnosed over 10 years ago, established on Levothyroxine 100 mg once daily, was referred by the GP with unusual sweating, palpitations, tiredness, anxiety, tremors and weight loss of around one stone over last few months. The thyroid function tests were suggestive of thyrotoxicosis with TSH of less than 0.05 mu/land FT4 60 pmol/l, hence the dose of levothyroxine was gradually reduced and ultimately stoppe...

A 69 year old lady was initially seen in clinic in August 2020 for a right adrenal incidentaloma which was discovered after she had a CT abdomen for diverticulitis related symptoms. She subsequently had a dedicated CT Adrenal in January 2019 before she was seen in clinic which showed a 25 x 32 mm right adrenal adenoma labelled as lipid poor with an absolute & relative washout of 67% and 47% respectively. Her past medical history included hypertension and anxiety disorder. ...

Introduction: Hypogonadism is linked to anaemia, sarcopenia and osteoporosis in men. Whereas secondary hypogonadism (SH) is biochemically indistinguishable from nongonadal illness, primary hypogonadism (PH) can be easily diagnosable by the identification of raised gonadotropins.Case Presentation: A 66-years old male with a background history of type 2 diabetes mellitus, arthritis, and hypertension was referred to the haematology services to investigate h...

Aim: If ‘0’minute salivary cortisol (SALCORT_0) or cortisone (SALCONE_0) can predict normal post-synacthen cortisol response.Method: Baseline salivary sample was collected for 110 patients who had short synacthen test (SST) between 09:00 and 10:00 after hydrocortisone withdrawal for at least 24-hour. SST was labelled ‘pass’ if 30-minute serum cortisol was >450 nmol/l. Serum cortisol was measured by immunoassay whereas salivary cor...