Endocrine Abstracts

The hepatic enzyme 5β-reductase (AKR1D1) sits at the interface between two metabolic pathways, converting steroid hormones to their inactive 5β-reduced metabolites during steroid clearance, and as a step in the synthesis of bile acids from cholesterol. Both the steroid substrates and the bile acid products of AKR1D1 are potent hormones that regulate hepatic energy metabolism and inflammation. It is not known how these two functions are spatially organised within hepa...

18 year old female was referred to endocrinology from Paediatric and adolescent gynaecology with secondary amenorrhea. She had her menarche at age of 15 years with profuse bleeding for three days only, no spontaneous periods afterwards. She had no symptoms of weight gain, increased hair growth, galactorrhea, headache or any skin changes. She had significant history of hair loss. She had normal milestones. She achieved her adrenarche and thelarche at age of 12-13 years. Family ...

Subcutaneous hydrocortisone (HC) infusion using continuous (CSHI) and pulsatile (PSHI) regimes are treatment options for adrenal insufficiency. It is an off-labelled treatment in UK for patients with adrenal insufficiency (AI). We surveyed 8 cohorts via Cortisol Pump UK support group in Facebook to capture their data in the following area: Quality of Life AddiQoL scores 24 h infusion doses & type of...

Background: Bariatric surgery can profoundly ameliorate hyperglycemia and improve insulin sensitivity thus contribute to diabetes remission. However the detailed mechanisms underlying this effect is yet to be revealed. The aim of this research is to investigate the metabolic alterations in skeletal muscle after bariatric surgery and explore the possible mechanisms to further explain the diabetes remission effect of bariatric surgery.Methods: Duodenal-jej...

Background: The purpose of this study was to register the frequency and cause of method-dependent interference in the Roche thyroid immunoassays observed in our laboratory.Methods: Serum samples to confirm discordant thyroid results were collected from June 2013 to September 2018, in samples sent to the Hormone Laboratory, Oslo University Hospital. The laboratory serves as a reference laboratory on thyroid diseases for about 2/3 of the inhabitants of Nor...

Somatostatinomas are rare neuroendocrine tumors diagnosed at a rather young age (mean age at diagnosis from 40 to 60 years). Non-auto-immune diabetes may associate with somatostatinoma as a result of abnormal somatostatin secretion, which inhibits insulin release. Steatorrhea and cholelithiasis are two other classical symptoms of these tumors. Here we report a case of somatostatinoma discovered while exploring a recently diagnosed diabetes, whose clinical and biological featur...

Introduction: Adult Growth Hormone Deficient (AGHD) patients have often a difficult path from diagnosis to treatment. A patient advisory panel was conducted to better understand the AGHD patient journey and how this could be supported. This format was chosen to allow for direct patient to patient interactions and discussions and for physicians to learn.Findings: A total of nine patient advisors (three childhood-onset; six adult-onset, age 33–67 year...

Background: The detection of thyroid incidental uptake of radiopharmaceuticals has been increasing. Those detected by 18F-fluorodeoxyglucose positron emission tomography (PET) have been associated with a significant risk of malignancy (8–64%). Gallium-68 (Ga-68) labelled peptides are now the standard imaging modality for staging neuroendocrine tumours (NET). Its high sensitivity has increased the discovery of incidental findings. The aim of this study was to ev...

Currently national and international guidelines for imaging procedures for high risk and advanced prostate cancer (PCa) include abdomino-pelvic cross sectional imaging, multiparametric prostate MRI, bone scintigraphy and in the case of therapy monitoring of mCRPC whole body cross-sectional imaging mainly by means of computed tomography. Positron emission tomography (PET) has become increasingly important in the work-up of prostate cancer. Recently, a 68Gallium-label...

Ga-68 labelled urea-based inhibitors of the prostate specific membrane antigen (PSMA), such as 68Ga-HBED-PSMA-11, are promising peptides for targeting prostate cancer. The tris(hydroxypyridinone) (THP) ligand rapidly complexes 68Ga3+ at room temperature, at very low concentration and over a wide pH range, making it possible for the direct elution from a 68Ge/68Ga generator into a cold radiopharmaceutical kit in one step wi...