Endocrine Abstracts

Hyperthyroidism in Graves’ disease is due to TSH receptor (TSHR) autoantibodies (TRAb) directed against the TSH binding pocket. Detection of TRAb in clinical rou-tine is performed by 2nd gen assays using human or porcine TSHR. Such TSH bin- ding inhibition immunoglobulin (TBII) assays determine the ability of TRAb to inhi- bit the binding of labelled TSH to immobilized TSHR. TRAb are present in low con- centrations and mostly recognize conformational epitopes. The conform...

177Lu-labelled compounds show many advantages for dosimetry assessments due to the attractive physical properties of the isotope which comprise a clearly separated gamma peak at 208 keV and low abundance of photons which permits reliable quantitative imaging after therapy. In addition, the low range of beta particles is advantageous for radiation protection. This talk mainly focuses on dosimetry methodology which includes consideration of the number and time points ...

Introduction: Humans with glucocorticoid receptor (GR) deficiency and global heterozygous GR knockout (GR+/−) show compensatory activation of the hypothalamic-pituitary-adrenal axis, resulting in salt-sensitive hypertension due to increased mineralocorticoid activity. Previous studies suggest renal mechanisms, including changes in cell proliferation, gene expression and electrolyte transport, may contribute to this phenotype but underlying adaptive adrenal responses have...

Introduction: Bone marrow is an abundant source of adult stem cells that can differentiate into various cell types. Administration of mesenchymal stem cells (MSCs) in irradiated diabetic rat model has transiently shown to decrease blood glucose level. This study examines the effect of high dose and multiple injections of MSCs on glycaemic profile, their localisation and regeneration of islet in diabetic Wistar rat.Methods: The study was carried out in ma...

Introduction and Aims: Thyroid lesions constitute a frequent consultation in the area of endocrinology. Fine-needle aspiration (FNA) cytology is a gold standard for the evaluation of thyroid lesions, while ultrasound examination according to various thyroid imaging reporting and data system (TIRADS) criteria is gaining importance in the field. The aim of our study was to compare the sensitivity and specificity of both techniques in patients attended in thyroid lesion unit of o...

Background and Aim: Hepatic de novo lipogenesis (DNL) has been implicated in the development of non-alcoholic fatty liver disease (NAFLD). Supplementation with the omega-3 fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) decreases intrahepatic triacylglycerol (IHTAG) and plasma TAG concentrations, which is suggested to be mediated through changes in hepatic DNL. We investigated the effects of omega-3 FA supplementation on intrahepatic DNL an...

Objectives: To establish the frequency of islet cell autoimmunity in children with a clinical diagnosis of type 2 diabetes (T2DM) and describe associated clinical and laboratory findings.Methods: We recruited children with: paediatrician diagnosis of T2DM; BMI above 85th centile for age and sex; children with other confirmed diagnoses such as monogenic and type 1 diabetes (T1DM) were excluded. Clinical data was collected into a national database. Blood w...

Objectives: To establish the frequency of islet cell autoimmunity in children with a clinical diagnosis of type 2 diabetes (T2DM) and describe associated clinical and laboratory findings.Methods: We recruited children with paediatrician diagnosis of T2DM and body mass index (BMI) above 85th centile for age and sex. Patients with other confirmed diagnoses such as monogenic and type 1 diabetes (T1DM) were excluded. Clinical data was collected into a nation...

Many (40%) patients with medullary thyroid carcinoma (MTC) are cured after initial surgery, others may survive for decades despite persistent disease, and few patients with advanced disease (estimated annual incidence in France: 50 cases) may require novel therapeutic modalities. An activating RET mutation is found in all hereditary MTCs and in half of sporadic MTCs, and is believed to be responsible for the neoplastic transformation of C-cells and for their development. Drugs...

Annexin 1 (ANXA1) is a glucocorticoid-regulated, calcium and phospholipid-binding protein well recognized as an important signalling intermediate in both peripheral systems and the brain. Online adult mouse brain gene libraries have reported ANXA1 mRNA expression in the subventricular zone (SVZ) lining the lateral ventricles. The SVZ is one of the two largest neurogenic areas of the brain and as ANXA1 plays a known role in cell differentiation and proliferation, we have invest...