Endocrine Abstracts

Background: Alpelisib is a novel phosphotidylinositol 3-kinase (PI3K) inhibitor which, in combination with fulvestrant, has been shown to increase progression-free survival in patients with HR+/HER2-/PI3KCA mutated advanced breast cancer[1]. Hyperglycaemia, including alpelisib-induced diabetic ketoacidosis is a known adverse effect, along with rash, diarrhoea and stomatitis. No other associated endocrinopathy has been reported to date. Case presentation: We present th...

In recent years, there has been increasing evidence for the hypothesis of bones as endocrine organs. Osteocalcin, long considered just a marker of new bone formation, is now seen as the first hormone produced by bones, and seems to be associated with regulating glucose metabolism and reproduction. The aim of this work was to monitor changes of osteocalcin in reaction to hypoglycaemia, and determine if there are differences in such reactions between the sexes. The study include...

The production and activities of steroid hormones during pregnancy have many interesting aspects. Their synthesis and metabolism are the result of complex metabolic pathways encompassing activities in the fetus, placenta, and mother. Progesterone, estrogens, androgens and glucocorticoids all play important roles during pregnancy, from implantation to delivery. Focusing on selected steroid hormones in the peripartum period, we defined reference ranges measured using LS-MS/MS, a...

Dehydroepiandrosterone is the most abundant steroid hormone circulating in the human body, we focused on its 7-hydroxylated derivatives. Many observations in rodents have demonstrated the anti-inflammatory and immune modulating activity of 7β-hydroxy-androst-5-enes, and on the basis of these experiments androst-5-ene-3β,7β,17β-triol is considered as a potential agent in the treatment of autoimmune diseases. In contrast to the fairly abundant information on ...

Smoking has many effects on human health and reproduction. Women are generally recommended to quit smoking before conception. Cessation improves fertility and helps avoid many health risks for the mother and the child and plays an important role in the future development and health of the offspring. We have decided to perform a study following changes in the production of steroid hormones in pregnant smokers and ex-smokers compared to non-smokers. In physiological pregnancies,...

Abstract: Dihydrotestosterone (DHT) is the most powerful naturally occurring androgen with three to six times higher biopotency than testosterone. Time onset of benign prostatic hyperplasia and alopecia in middle life could be the result of an imbalance between androgens. The decline of testosterone during lifespan is well known, controversial data can be found concerning the age dependence of DHT levels. We analysed the levels of testosterone, dihydrotestosterone and SHBG fro...

17α-hydroxyprogesterone (17OHP) is currently used as a diagnostic parameter in children and young adults when a milder form of congenital adrenal hyperplasia (CAH, late-onset) is suspected. A basal serum level of 17OHP (2 ng/ml; 6.0 nmol/l, respectively) has been discussed as cut-off for suspected late-onset disease. We analysed 17OHP in a cohort of children and adolescents without CAH and in confirmed CAH patients to define reference ranges for these age...

Introduction: A precisely measured corticoid level is important for decision-making in daily clinical practice. These levels can be influenced in the pre-analytical phase, when the effect of stress, timing, and diet can be important.The aim of this study was to elucidate optimal conditions for blood sampling as well as the choice of analytical methods, which they will be used in measuring of corticoids.Methods: By studying ten wome...

Background: Secretion of insulin by beta-cells of the islets of Langerhans is a very complex dynamic process that includes basal and stimulated insulin secretion. Two phases, one early and one late, can be distinguished in insulin secretion. The early phase is characterised by the secretion of preformed insulin granules, lasts about 15 min and is formed by cephalic and gastrointestinal components. The cephalic phase of insulin secretion starts by stimulating visual, olfactory ...

Introduction: The influence of steroid hormones on food intake is well described. However, there are only a few studies on the effect of food intake on steroid levels.Methods: The study involved eight non-smoker women (average age 29.48±2.99 years; average BMI 21.3±1.3 kg/m2); they did not use any kind of medication affecting steroidogenesis. We analysed the influence of four various stimuli on the levels of steroid hormones and mela...