Endocrine Abstracts

Background and aims: To evaluate the evolution of thyroid cancer epidemiological characteristics from 2004 to 2014.Materials and methods: Retrospective analysis of histological data from thyroidectomies performed in our hospital in the period 2004–2014.Results: From 2004 to 2014, 2725 thyroidectomies (women 81% vs men 19%) were performed in our hospital. In 1083 of these (40%) histologic examination revealed thyroid cancer.</p...

Adrenocortical carcinoma (ACC) is a rare, heterogeneous malignancy with aggressive behavior and poor prognosis, particularly when metastatic at diagnosis. To date, radical surgery, possibly associated to mitotane adjuvant therapy, is considered the best option for ACC treatment. However, the mean 5-year survival rate diminishes dramatically in metastatic ACC and chemo-resistance often develops. Thus, more specific and effective drugs for ACC treatment are urgently required. Th...

A number of evidence indicate that mood (affective) disorders are influenced by various bioactive steroids such as corticoids, sex hormones and neuroactive steroids. However, to date, there are limited data concerning the discrimination between patients suffering from the disorders and controls, or regarding the classification of individual subtypes of mood disorders on the basis of steroid profiling. Therefore 47 steroids including their conjugates and further related substan...

Adrenocortical carcinoma (ACC) is a rare, heterogeneous malignancy with a poor prognosis, particularly when metastatic at diagnosis. To date, radical surgery, possibly associated to mitotane adjuvant therapy, is the only available treatment. However, the mean 5-year survival rate drops under 10% in metastatic ACC and chemo-resistance often develops. Thus, more specific and effective drugs for ACC treatment are urgently required. The antidiabetic drug metformin, used in type 2 ...

HbA1c, which is correlated with 3-month mean glycaemia, is usually measured every 3–6 months. Effects of variations of treatment are routinely assessed through HbA1c not earlier than 3 months. Glycated albumin (GA) has been proposed as an indicator of shorter-term (2-week) glucose control Aim of the present pilot study was to explore the possibility of predicting 3-month HbA1c by measuring HbA1c or GA at 15–30 days. Twenty-seven metformin-treated patients with type 2...

Introduction: Obesity increases the incidence of hypogonadism in men, and hypogonadism in turn plays a role in obesity. One of the first mechanisms proposed to explain this was a hypothesis based on the principle that obese men have higher estrogen levels, and that increased estrogens provide feedback to the hypothalamic-pituitary-testicular axis, reducing the secretion of gonadotropins and leading to a decrease of overall testosterone levels. This concept has since been quest...

Introduction: Tobacco dependence is considered to be a serious psycho-social problem. Chronic smoking can cause fertility disorders with both sexes. The literature brings up contradictory results in relation to the effects of the smoking on the steroid hormones levels. Only a few papers discuss the effect of the nicotine addiction treatment.Methods: We observed 26 smokers who decided to quit smoking and abstained from smoking for one year. With everyone ...

Introduction: The dependence on tobacco, diagnosis F 17, is an independent condition in the International classification of diseases and presents one of the most widespread addictions. Chronic smoking can cause impairment of fertility in both sexes. However, only a small number of studies were dedicated to the influence of smoking on levels of steroid hormones and their neuroactive metabolites. Neuroactive steroids modulate the effects of tobacco on central nervous system, and...

Objective: Chronic smoking alters the circulating levels of sex hormones and possibly also the neuroactive steroids, however, the data available is limited.Patients and methods: Therefore, a broad spectrum of free and conjugated steroids and related substances was quantified by GC–MS and RIA in premenopausal smokers and in age-matched (38.9±7.3 years of age) non-smokers in the follicular (FP) and luteal phases (LP) of menstrual cycle (10 non-sm...

Background: Smoking represents the most widespread substance dependence in the world. Several studies show the nicotine’s ability to alter women hormonal homeostasis. Women smokers have higher testosterone and lower estradiol levels throughout life compared to women non-smokers. This negatively affects women reproductive function. Furthermore, alteration of neuroactive and neuroprotective steroids occurs in women smokers, which plays an important role in the activity of t...