Endocrine Abstracts

Objective: Gestational diabetes mellitus (GDM) is strongly associated with maternal obesity. Omentin-1 is secreted from the adipose tissue and enhances insulin action. Circulating levels are inversely correlated with body weight, decreased in type 2 diabetes. Pre-existing maternal obesity has been shown to be associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. In our previous study, we had shown that plasma omentin-1 level is decreased i...

Objective: Irisin is a novel adipomyokine that regulates the differentiation and phenotype of adipose tissue. It induces an increase in total body energy expenditure, improves insulin sensitivity, and glucose tolerance. It showed that the levels of irisin are low in obese, diabetic and impaired glucose tolerance patients. However, the information of the levels of circulating irisin in gestational diabetes mellitus (GDM) is controversial. In this study, we investigated i) the l...

Introduction: It is unclear whether ultrasonographic (US) findings and fine-needle aspiration biopsy (FNAB) results of nodules accompanied with Hashimoto’s thyroiditis (HT) are affected by the presence of thyroiditis or not. In this study, we compared US features and cytological results of nodules in patients with and without HT.Methods: Patients who underwent FNAB in our clinic were evaluated prospectively. Nodules in patients with and without HT w...

Aim: Exophytic nodule refers to a nodule that sticks out of the normal thyroid boundary/outline. Other definition is a nodule with an acute angle between the lesion and adjacent thyroid capsule. In the literature, one study reported that thyroid nodules with exophytic configuration showed a high malignancy rate. We aimed to compare ultrasonographical features and cytopathologic results of exophytic and non-exophytic thyroid nodules.Material and method: T...

Introduction: Diabetes insipidus (DI) is a disease characterized by excessive thirst, polydipsia and excess diluted urine caused by insufficiency of antidiuretic hormone or renal resistance to its effect. Although it is generally a benign condition, severe hypernatremia and hypertonicity may cause death if water loss is not compensated.Case report: A 72-years-old man admitted to our clinic for routine control. In medical history, he told that when he was...

Introduction: Leri–Weill dyschondrosteosis (LWD) is a rare autosomal dominant dyschondrosteosis characterised by Madelung deformity and mesomelic dwarfism. Majority of cases are associated with haploinsufficiency of the short-stature homeobox-containing (SHOX) gene. Here we report a patient with LWD and diabetes mellitus (DM).Case report: A 31 years old man applied with polyuria and polydipsia. He did not have any chronic disease. In family history,...

Aim: The Swyer syndrome belongs to a group of pure gonadal dysgenesis. Karyotype is 46,XY. Aberrations of chromosome Y or SRY gene mutation is present in 15–30% of cases. These patients have high gonadotropin levels and are classified as having hypergonadotropic hypogonadism. The Swyer syndrome in the female requires close followup because of the high risk of neoplastic transformation in the dysgenetic gonads. Herein we report a case of Swyer syndrome with gonadoblastoma ...

Background: Postoperative severe polyuria is a rare condition after adrenal pheochromocytoma resection. We presented this case due to its rarity.Case: A 50-year-old women admitted to emergency service with malaise and fatigue complaint. The patient was using triple antihypertensive combination that started 10 years ago. Her medical history included cerebrovascular event due to hypertension 5 years ago. In physical examination her BMI was 20 kg/m2</s...

Introduction: Insulinoma is a rare neuroendocrine tumor. 90% of insulinoma is solitaire and benign, and 10% is malignant. Although seen at any age, it is most commonly noticed in 4th and 6th decades.Case: A 78-year-old man was referred to a neurology clinic upon a sudden faint, disability to remember and meaningless behavior, and diagnosed with epilepsy in 2008. In 2012, he had a hypoglycemia attack (blood glucose 30 mg/dl) and was referred to Ege Univer...

Introduction: Wolfram syndrome has characterized by central diabetes insipidus (DI), diabetes mellitus (DM), optic atrophy (OA) and deafness. In this report we presented a Wolfram syndrome with hypergonadotropic hypogonadism.Case: A 18-year-old girl who has diabetes for 6 years was hospitalized due to blood sugar irregularity. Her medical history revealed frequent urination and enuresis for 2–3 years and primary amenorrhea. Furthermore she had hear ...