Endocrine Abstracts

Aim: Mitotane (o,p′-DDD) has been used to treat adrenocortical carcinoma (ACC) for several decades. Mitotane is often given in adjuvant setting after surgical resection of ACC and treatment usually lasts 2–3 years to reduce ACC recurrence. The use of mitotane is associated with multiple adverse effects. We herein report a case of marked hypercholesterolemia in a man receiving mitotane as adjuvant chemotherapy for ACC.Case: A 64-year-old man wa...

Transsexuality is characterised by a belief of having been born in a wrong body. Sexual differentiation of genitals take place in the first 2 months of pregnancy. Sexual differentiation of brain takes place in the second half of pregnancy. It is found that there is structural sex differences in the central nucleus of the bed nucleus of the stria terminalis (BSTc). Structural differences were found to be reversed in transsexual people. In humans main mechanism appears to involv...

Background: Diabetes is very common disorder. Many studies have shown that patients with diabetes mellitus have incresing trombotic complications both arterial and venous trombosis. Bad control diabetes increases risk of trombosis. Recent reports have shown that shortened APTTs and increased fibrinogen indicate procoagulan situations. In this study, we aimed to evaluate whether chronic hyperglisemia or bad control diabetes causes trombosis which is reflected by shortened APTTs...

Acromegaly is usually regarded as a disease which occurs sporadically. Familial occurence of acromegaly due to pituitary adenoma without any other endocrinopathy in a family is extremely rare. These patients should be evaluated for multiple endocrine neoplasia type 1 (MEN 1) and Carney complex. We report here two cases of acromegaly due to pituitary macroadenomas. Subject 1 is a 50-year-old woman and subject 2 is her 23-year-old son with elevated growth hormone (GH) levels dur...

Objective: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a very rare congenital anomaly characterised by vaginal agenesis and a spectrum of different genitourinary tract anomalies. Typical form of this syndrome is characterised by congenital absence of the uterus and upper 2/3 vagina with normal ovaries and fallopian tubes and atypical form of the syndrome is associated with anomalies of the ovaries and fallopian tubes and renal anomalies.Case r...

A 37-year-old patient with a history of transcranial pituitary surgery because of acromegaly was referred to our clinic with the glucose level 731 mg/dl. she was not using any medication. There was no ketone in the urine and HbA1c was 18.6%. She has 17×16×15 mm of residual macroadenoma on pıtuıtary MRI with level of GH 17.5 ng/ml and IGF-1 422 ng/ml. She was using 140 units of insulin glargin U300 and 100 units of insulin regular per a day before octreotide...

Purpose: In previous studies, magnesium (Mg) was found to be lower in cases with more severe primary hyperparathyroidism (PHPT) and higher calcium (Ca) levels. This study evaluated the relationship between serum Mg and serum Ca and phosphorus (P) levels in PHPT and their utility in discriminating osteoporosis and nephrolithiasis.Methods: Patients who were followed up with PHPT between March 2019 and March 2023 were analyzed retrospectively. Biochemical d...

Introduction and Aim: In our study, the frequency of exocrine pancreatic insufficiency, and its relationship with the duration of diabetes and the level of glycemic control and other complications of diabetes were investigated in patients with diabetes mellitus.Materials and Methods: This paper was supported by Manisa Celal Bayar University Scientific Research Projects Coordination Unit, Project Number 2021-086. A total of 249 diabetic patients, 21 with ...

Aim: Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease characterized by increased levels of low density lipoprotein cholesterol (LDL-chol). Despite relatively high prevalance and significant association with increased mortality, the awareness of physicians and patients is low and it is an underdiagnosed and undertreated disease. We aimed to detect patients with FH and determine treatment status and compliance.Materials and metho...

Introduction: Parathyroid carcinoma (PC) is a rare endocrine malignancy which accounts for 0.005% of all cancers and less than 1% of primary hyperparathyroidism cases. This uncommon tumor usually occurs during the fifth decade of life, with equal frequency in both sexes, and has an indolent but progressive course. It’s frequently symptomatic and patients may have high values of serum calcium and parathyroid hormone (PTH) with a palpable cervical mass. PC generally occurs ...