Endocrine Abstracts

Introduction: Type B insulin resistance is an extremely rare disease with unknown incidence. It is caused by autoantibodies, mostly IgG, against the insulin receptor that in low titres act as partial agonists. This can cause symptoms that include both hypoglycemia and hyperglycemia. It mostly affects middle-aged African-American women and the proposed treatment approaches include plasmapheresis, cyclosporine or cyclophosphamide, steroids and rituximab.Ca...

Introduction: Insulin autoimmune syndrome (Hirata’s disease) is a rare cause of hypoglycemia in Caucasians, with an estimated prevalence of 0,017 cases per 100.000 in general population. It is characterized by mostly postprandial hypoglycemia and the presence of autoantibodies against insulin. Treatment options include dietary modifications, glucocorticoids, azathioprine, rituximab and plasmapheresis.Case report: A 72-year-old woman with no medical ...

Aim: To investigate the association of endocrine complications after ICIs immunotherapy with progression free survival (PFS) and overall survival (OS) in a large single-center oncological cohort.Patients and methods: In total, 351 patients were included in the analysis, 248 men (70.7%) and 103 women (29.3%). The median age was 66 years. Patients had a variety of cancer types, namely bladder cancer (131, 37.3%), renal cancer (89, 25.4%), lung cancer (74, ...

Objective: Recent evidence reports a controversial extra-gonadal role of follicle stimulating hormone (FSH). Conflicting data support that the association between FSH and obesity might be maintained by a direct or even indirect effect to the adipose tissue. The aim of this study was to evaluate the associations between FSH concentrations and various obesity indices in women after menopause.Methods: This cross-sectional study included 420 postmenopausal w...

Aim: To investigate reproductive function disorders in young women with type 1 diabetes mellitus (T1DM).Patients and methods: We studied 53 women with T1DM (duration 8.0±5.6 y) and 51 healthy controls with normal menstrual cycles and no clinical hyperandrogenism, matched for age (19.4±4.3 vs 20.8±3.1 years, P=0.063) and body mass index (BMI) (22.2±2.7 vs 21.4±1.9 kg/m2, P=0.088). T1DM (insulin regimen...

Introduction: The aim of this study was to evaluate predictors of metabolic disease in normal weight postmenopausal women.Patients and Methods: This cross-sectional study included 457 non-obese postmenopausal women, recruited from the Menopause Clinic of Aretaieio Hospital, National and Kapodistrian University of Athens. The diagnostic criteria of the International Diabetes Federation for the definition of Metabolic Syndrome were used, in order to classi...

Introduction: Recent evidence reports a controversial extra-gonadal role of follicle stimulating hormone (FSH). Conflicting data support that the association between FSH and obesity might be maintained by a direct or even indirect effect to the adipose tissue. The aim of this study was to evaluate the associations between FSH concentrations and various obesity indices in women after menopause.Patients and Methods: This cross-sectional study included 420 ...

IntroductionRecent evidence suggests a possible link between prediabetes and lower density in postmenopausal populations. Moreover, earlier data suggest a link between diagnosis of diabetes and lower levels of bone density in women after the menopausal transition. We aimed to evaluate the possible association between insulin resistance and a diagnosis of lumbar or hip osteoporosis and/or prevalent fractures of the lumbar spine. Met...

IntroductionMenopausal transition is associated with an increase in the cardiovascular risk, possibly related with the sharp decrease of estrogen levels. Menopausal symptoms and more specifically hot flushes have been previously linked with an increase in cardiovascular risk. On the other hand, non-alcoholic fatty liver disease is considered as another presentation of the metabolic syndrome, conferring additional cardiovascular risk to the affected indiv...

Background: The menopausal transition has been associated with a heightened risk of cardiometabolic complications, including new onset diabetes mellitus (NODM). Statin-use increases the NODM-risk in the general population, however, their impact on NODM-risk specifically in postmenopausal populations has not been adequately studied.Objectives: To estimate the effect of statin-use at baseline on the risk of NODM in postmenopausal women.<p class="abstex...