Endocrine Abstracts

Background: The use of Flash Glucose Monitoring (FGM) for the management of type 1 diabetes mellitus (T1D) is rapidly increasing.Aims: To assess the longitudinal evolution of glycated haemoglobin (HbA1c) and body mass index (BMI) with the use of FGM in patients with T1D; to determine predictive factors of benefit with the use of this technology.Materials and methods: Retrospective study of T1D patients, using FGM ≥6 months an...

Background: Clinically non-functioning pituitary macroadenomas (NFMA) have been reported to express various somatostatin receptor (SSTR) subtypes, but results are inconsistent across different studies. This may be related to limited sensitivity and specificity of techniques used to date, i.e. immunohistochemistry in surgical specimens and 111In-DTPA-octreotide scintigraphy (Octreoscan) in vivo. The aim of this study was to assess SSTR expression in NFMA <em...

Objective: Pituitary diseases cause a wide range of local and systemic symptoms and severely affect patients’ health-related quality of life (HRQoL), which can be monitored using both disease-specific and generic questionnaires. The most frequently used generic HRQoL questionnaire is the Short Form-36 (SF-36), generating a mental (MCS) and physical component score (PCS). The shorter 12-item version (SF-12) can improve efficiency of patient monitoring and outcome measurem...

Background: Hashimoto thyroiditis (HT) is the most common autoimmune disease and patients may present different levels of thyroid dysfunction. The association between hypothyroidism and cardiovascular events is well established. However, it remains unclear how mild thyroid dysfunction, autoimmunity and chronic inflammation in HT contribute to an increased cardiovascular risk in euthyroid patients and in subclinical hypothyrodism. Therefore, this study aims to assess insulin re...

Background: Transsphenoidal surgery is standard care in the treatment of hormone-secreting pituitary adenomas. Current clinician-reported surgical outcome measures are one-dimensional, typically focussing primarily on complete or partial resection and secondarily on complication rates. However, outcomes are best reflected by the delicate balance of efficacy and complications at patient level. This study proposes a novel way to classify outcome, integrating efficacy and safety ...

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic disease, with prevalence increasing worldwide and its complications are major causes of early morbidity and mortality. Recent guidelines suggest the individualisation of glycaemic targets and glucose-lowering therapies.The aim of this study was to determine the quality of care provided to type 2 diabetic patients in our institution, analysing metabolic control, cardiovascular risk factors and pre...

Triorganotins, such as tributyltin (TBT), are environmental contaminants commonly found in antifouling paints that are used on the ships and other vessels. Unfortunately, these chemical are also suspected to cause endocrine-disrupting effects in mammals, due in part to their possible transfer through marine food chains and to the consumption of contaminated seafood. The importance of triorganotins as environmental endocrine disruptors in different animal models is well known; ...

Aim: To define the main predictors of metabolic control in children and adolescents and evaluate its improvement along the years.Methods: We included children and adolescents with 1DM, with more than two years of disease. Data were collected at 2005 and at 2012. Sex, age and severity at diagnosis, therapy in the last year, age at onset of multiple daily insulin injections (MDII) and continuous subcutaneous insulin infusion (CSII), number of group educati...

Introduction: IgG4-related Hashimoto’s thyroiditis (HT) is a very recently reported entity, characterized by thyroid inflammation rich in IgG4-positive plasma cells associated with marked fibrosis. It may be part of the systemic IgG4-related sclerosing disease and is associated with younger age, lower female:male ratio, higher levels of thyroid autoantibodies, low echogenicity on ultrasound (US), rapid progress requiring surgery and more subclinical hypothyroidism, when c...

Objective: To evaluate the interrelationships between Graves’ disease (GD) and cardiovascular risk factors.Subjects and methods: We analyzed thyroid function tests, anti-thyroid antibodies, BMI, insulin resistance markers, namely homeostasis model assessment for insulin resistance (HOMA-IR and HOMA-B), the quantitative insulin sensitivity check index (QUICKI), hepatic insulin sensitivity index (HISI), whole-body insulin sensitivity index (WBISI), in...