Endocrine Abstracts

Introduction: Papillary thyroid carcinoma (PTC) is the most frequent endocrine malignancy. Apart from genetics, autoimmunity has been implicated in its pathogenesis. In this context, we set out study the role of Pro- inflammatory cytokines in PTC in South Indian population.Material and methods: This prospective case-control study was conducted on surgically managed PTC patients. Institutional ethical committee approval was obtained. Diagnosis of PTC was ...

Introduction: Thyroidectomy can performed by open or wide array of endoscopic techniques. Lack of uniform consensus on specific indications for each technique leads to confusion on ideal thyroidectomy technique. In this context, we analysed our experience with specific emphasis on deducing an algorithm on ideal technique for a given patient. Material and methods: This is a retrospective study conducted at a tertiary care endocrine surgery department in S...

Background: Preeclampsia (PE) continues tochallenge both the clinicians and researchers worldwide, as the existing knowledge on its etiopathology does not come up with an efficient and foolproof treatment regime due its progressive nature and uncertain diagnosis and prognosis. In this context, miRNAs represent a potential therapeutic target and a diagnostic tool.Objectives: Circulating microRNAs present in maternal blood play an important role in the eti...

Background: Determining post-operative remission in Cushing’s disease is challenging. There is no consensus for the post-operative serum cortisol value which reliably predicts remission of Cushing’s disease following trans-sphenoidal surgery. Traditionally, an early post-operative serum cortisol of below 50 nmol/L has been used to predict remission, but achieving this is often at the expense of hypopituitarism.<p class="abst...

Background: Determining post-operative remission in Cushing’s disease is challenging. There is no consensus for the post-operative serum cortisol value which reliably predicts remission of Cushing’s disease following trans-sphenoidal surgery. Traditionally, an early post-operative serum cortisol of below 50 nmol/L has been used to predict remission, but achieving this is often at the expense of hypopituitarism.<p class="abst...

Background: Diabetes mellitus (DM) is the commonest endocrinopathy, Worldwide. Amongst the protean complex genetic variations, cubulin gene and megalin gene mutations in diabetes are important in dictating genotype-phenotypic correlations and natural clinical course of diabetes. The genetic studies in this area are especially very sparse from Indian sub-continent. In this context, we analyzed the prevalence of cubulin (CBN) and megalin (LRP2) gene mutations, as part of NGS (Ne...

Background: Follicular differentiated thyroid cancer (FDTC) is the most common endocrine cancer, globally. Next-generation sequencing (NGS) in thyroid cancer allows for high-throughput genetic sequencing in short time. This analysis offers useful information on tumor biology. NGS Studies on follicular differentiated thyroid cancer are scanty from South East Asia. In this context, we set out study the pattern of a genetic panel wide somatic mutations in thyroid cancer.<p cl...

Background: Acromegaly is associated with multiple co-morbidities and increased mortality. Surgery is the first-line intervention and remission of acromegaly can restore normal life-expectancy. Pre-operative somatostatin analogues (SSA) may increase the likelihood of remission in large invasive tumours by causing tumour shrinkage prior to surgery.Aims: To audit the management of acromegaly patients at Imperial College Healthcare NHS Trust (ICHNT) against...

Introduction: Granulomatous thyroiditis (GT) is one of the various types of autoimmune thyroiditis. It usually occurs in women of reproductive age in perigestational period. Clinical picture in is predominantly painful goiter with radiating pain to ears with low grade fever lasting for few days, sometimes associated with mild hyper or hypothyroidism. The treatment is symptomatic and supportive with no curative option. There are meagre anecdotal reports of thyroidectomy role fo...

Introduction: Hashimoto’s thyroiditis (HT) is one of the commonest endocrine disorder. Often, HT is associated with a plethora of autoimmune co-morbidities (AIC) such as vitiligo, arthitides, pernicious anaemia, skin allergy, thrombocytopenia, addison’s disease, type 1 diabetes, celiac disease, eosinophilia etc., The etiology of these AIC in HT is enigmatically idiopathic and hypothesized to be autoimmune in origin. Many studies suggests that thyroid specific antibod...