Endocrine Abstracts

Background: It has been proved that the adipose tissue is an active endocrine organ. It secretes a large number of adipokineswhich are involved in and affect regulation of metabolic process and can influence pathogenesis of atherosclerosis. Vaspin-new representative of adipokineswhich is secreted by adipose tissue and have an insulin-sensitizing properties. Vaspin engagement into atherosclerotic process poorly investigated.Aim: To establish the value of ...

Cardiovascular risk (CR) in patients with diabetes mellitus (DM) is high. Arrhythmias (Ar) could increase CR as well. We aimed to define is there any association between hyperglycemia and incidence of Ar. We studied 137 (75 F/62 M) type 2 diabetic patients with coronary artery disease (CAD). The age was 54.0±5.5 years (M±S.D). The CAD and DM duration <10 years was in 64 (47%) and in 47 (34%), 15 years and above – in 21 (15%) and in 34 (25%) re...

Neuropathy and ischemia play paramount roles in the pathogenesis of diabetic vascular complications. Reduced tissue blood flow in experimental diabetic complications can be corrected by several disease-modifying drugs. Actovegin (deproteinised hemoderivative product) is considered to be a potential agent to stimulate cellular energy metabolism and improve cell function. Testosterone vascular effects can be mediated via increasing cardiac and muscle activity and endothelium dep...

Background: World Health Organization (WHO), United Nations International Children’s Emergency Fund (UNICEF), and the International Council for Control of Iodine Deficiency Disorders included neonatal thyroid stimulating hormone (nTSH) as one of the indicators for assessing iodine deficiency at a population level and as a monitoring tool in programs of iodine supplementation. A prevalence of nTSH concentrations in dry blood spots (DBS) above 5 mlU/l below 3% has been prop...

Background: Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation and intellectual disability. The overall incidence of CH ranges from 1 in 3,000 to 1 in 4,000 live births, with variation worldwide among different ethnicity [1]. During the period 1993–2000 the incidence of CH in Lithuanian population was estimated as 1 in 4800 live births [2]. The aim of present study was to determine the incidence of CH among new-borns in Lithu...

Background and Aim: One of the greatest problem in pregnancy, complicated by diabetes is screening and appropriate care for women, whose diabetes is manifested during pregnancy. The study is aimed at gathering epidemiological data on gestational diabetes mellitus (GDM) and evaluating the of appropriate therapy in this condition.Materials and Methods: Screening for GDM was carried out in – 692 pregnant women. GDM was observed in 3.3% (22 women) and i...

Background: It is generally believed that glycemic targets in diabetic pregnancies should mimic those found in normal pregnancies.Aim: The aim of the present work was to reveal how glycemia indices in pregnant patients with type 1 diabetes mellitus (T1DM), their infants’ birth weight (IBW).Methods: Totally, 128 pregnant women with T1DM were enrolled in the study (mean age – 26±7 yrs; diabetes duration – 10.2&#17...

Multiple endocrine neoplasia type 2 (MEN2) is a hereditary condition with an autosomal dominant type of inheritance. It is evident that MEN2 is characterized by the presence of Medullary Thyroid Cancer (MTC) as a permanent symptom, the combination of which with pheochromocytoma and parathyroid syndrome is referred to as MEN-2A syndrome. The aim of our study was the creation of a database of patients with MTC and analysis of the data.Materials and methods...

The medical and social significance of the Multiple Endocrine Neoplasia type 2 (MEN2) is due to the severity of the manifestations of the disease components, namely the tumor process progression, a high risk of vascular accidents, pathological fractures of the femoral neck/spine, gastrointestinal bleeding, chronic renal failure. Late detection of pathology is associated with high mortality due to medullary thyroid cancer (MTC). Thus, the aim of the study was to establish the c...

BackgroundThe multiple endocrine neoplasia syndrome type 2 (MEN-2) is characterized by medullary thyroid cancer (MTC) as a permanent feature; the combination with pheochromocytoma and parathyroidism is referred as MEN-2a syndrome. The reason for hereditary forms of MTC is mutations in the proto-oncogene RET (RE-arranged during Transfection).The aim of the study was to establish the molecular determinants frequency of MEN-2 syndrome...