Endocrine Abstracts

Introduction: Previous studies reported increased unfavorable metabolic phenotype in patients with active acromegaly.Aim of the study: We studied the metabolic phenotype in unselected cohort of 133 patients with active acromegaly (83 female, 62.4%), diagnosed at Clinic of Endocrinology, University Clinical Center, Belgrade, Serbia in the period 2007–2018. Mean age at diagnosis of acromegaly was 50.5±1.2 years and mean BMI was 28.4±0.4 kg/m...

Introduction: Skeletal complications of acromegaly are among its most persistent and invalidating impacts. Dual-X-ray absorptiometry (DXA) alone might be insufficient or even misleading for bone health assessment in acromegaly.Patients and methods: Patients with acromegaly (N=170) were classified as active (N=104), operatively cured (N=34) or medically controlled (N=32). 57 males and 113 females were included, 52.8 (22...

Primary adrenal insufficiency (PAI) is uncommon in pregnancy. Women with PAI have reduced fertility and parity. If unrecognized or untreated during pregnancy PAI increases risk for maternal and foetal morbiditiy and mortality. Majority of women diagnosed before conception and appropriately treated, have uneventful pregnancies, with increased risk of cesarean section (CS) and preterm delivery.We report a 38-year-old woman with PAI during first spontaneus ...

It has been more than 70 years since the first adrenal incidentalomas (AI) were described. Most of these tumors are non-secreting, and are found in 4–7% of adult population. Patients with subclinical hypercortisolism (or autonomous cortisol secretion) (SH) are observed in 1–29% of patients with AIs. Evidence suggests that this condition may be associated with higher prevalence of diabetes, obesity, hypertension and osteoporosis.Between 1999 and...

It has been more than 70 years since the first adrenal incidentalomas (AI) were described. Most of these tumors are non-secreting, and are found in 4–7% of adult population. Patients with subclinical hypercortisolism (or autonomous cortisol secretion) (SH) are observed in 1–29% of patients with AIs. Evidence suggests that this condition may be associated with higher prevalence of diabetes, obesity, hypertension and osteoporosis.Between 1999 and...

Introduction: The most common cause for persistent elevation of TSH levels in hypothyroid patients treated with levothyroxine is poor compliance. The levothyroxine absorption test (LAT) is usually confirmed this phenomenon called “pseudo-malabsorption”.Case report: Sixty-year-old female, weight 60 kg, BMI 24.3 kg/m2, presented with sleepiness, tiredness, fatigue and forgetfulness. Her skin was very dry and flaky. She had low toleranc...

Pseudohypoparathyroidism type 1a (PHP1a) is disorder characterised by resistance to the biological actions of circulating parathyroid hormone (PTH) along with typical features of Albright’s hereditary osteodystrophy (AHO). Tissue-specific imprinting of GNAS gene results in complete resistance to PTH in renal proximale tubule, but skeletal responsiveness to PTH appears intact, since Gαs is biallelically expressed in human bones. The objective of this study was to dete...

Introduction: Glucocorticoids (GCs) are the treatment of choice for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined as serious side effects are great concern of GC therapy. The aim of the present study was to evaluate tolerability and safety of two different treatment protocols.Methods: Consecutive patients were divided according to the protocol of GC therapy into two groups: combined intravenous and ...

Introduction: Primary aldosteronism (PA) is a group of disorders which are characterized by inadequate and non-suppressible production of aldosterone. The prevalence of PA is increasing in hypertensive population. The golden standard of screening for primary aldosteronism, determination of aldosterone/plasma renin activity (ARR), is influenced by numerous exogenous and endogenous factors. Testing cannot always be conducted under optimal conditions.Object...

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. It is a heterogeneous disorder characterized by oligo- or anovulation (ANOV), biochemical or clinical manifestations of hyperandrogenemia (HA) and polycystic ovaries (PCO). Combination of these three characteristics makes four phenotypes of PCOS: phenotype 1 (ANOV+HA+PCO), phenotype 2 (ANOV+HA), phenotype 3 (HA+PCO) and phenotype 4 (ANOV+PCO). The difference...