Endocrine Abstracts

Introduction: Patients with aryl hydrocarbon receptor-interacting protein (AIP) gene mutations are predisposed to large, invasive, GH- or PRL-secreting pituitary tumours, occurring at a younger age and poorly responsive to treatment. The zebrafish (ZF) model provides anatomical and functional similarities to human neuroendocrine system.Methods: AIP knock down (KD) ZF embryos were generated using antisense morpholino oligonucleotides injected at one-cell ...

Positron emission combined with computed tomography using 18F-deoxy-glucose (FDG–PET/CT) is increasingly used in the staging and detection of malignant disease. Normal pituitary is not visualized by routine FDG–PET/CT and its radiological evaluation relies predominantly on magnetic resonance imaging (MRI). The role of FDG–PET/CT in differential diagnosis of sellar mass, in patients investigated for malignant disease, will be discussed.<p class="ab...

Introduction: Generously supported by IPSEN)-->Active acromegaly is reported to be associated with considerable body composition changes, with significant lean body mass changes found only in men.Patients and methods: In patients with active acromegaly (n=40) 24 females and 16 males, 48.9±6.4 years old, with BMI of 28.04±1.27 kg/m2, diagnosed 4.15±1.09 years ago, body composit...

Background: Generously supported by IPSEN)-->Hypopituitarism is considered to be a risk factor for cardiovascular disease and early death in humans. However, some studies showed that most patients with isolated GH deficiency or combined pituitary hormonal deficiency due to gene mutations (PROP 1, GH receptors gene, GH-1 gene) can survive to advanced age.Aim: To collect clinical data on patients with congenital ...

Background: Literature data regarding the prevalence of the syndromes of thyroid autoimmunity (AIT) in antiphospholipid syndrome (APS) are rather limited. However, quite frequently it is hypothesized on common pathophysiologic mechanisms underlining these disorders.Objectives: The aim of this investigation was to evaluate the frequency of disorders of thyroid function and occurrence of anti-thyroid antibodies (ATAs) among patients with antiphospholipid s...

AimsTo present the case of a 69 year-old female patient who was diagnosed with acromegaly two years following the initial onset of facial and acral symptoms, having already developed colonic hyperplastic polyps, one of the complications associated with acromegaly, one year prior to diagnosis.MaterialCase report and literature review.MethodAcromegaly was diagnosed ...

Background: The partial or complete hypopituitarism is described as late complication of hemorrhagic fever with renal syndrome (HFRS). Imaging methods of pituitary gland examination in the chronic phase showed pituitary atrophy, but a precise pathogenic mechanism that causes pituitary damage in HRFS remains unclear. While hypopituitarism in HFRS is rarely described, cardiac failure as a known complication of hypopituitarism is even more rarely described. We present a case of s...

Introduction: We present two pregnant women who were referred to obstetric endocrinology service with polyuria and polydipsia. They were investigated and treated for diabetes insipidus (DI). In both cases, the underlying pathophysiology was ADH insufficiency secondary to autoimmune lymphocytic hypophysitis. There are currently no consensus guidelines on the diagnosis of DI during pregnancy. These cases highlight best practice and endorse MDT management of chronic hypopituitari...

Introduction: Association between lymphoma and pituitary dysfunction is well documented, though most commonly through mechanism of infiltrative pituitary metastasis, or primary lymphoma of the pituitary, rather than autoimmune lymphocytic hypophysitis. Here we present a highly unusual case whereby investigation into the cause of Diabetes Insipidus with radiological features of lymphocytic hypophysitis, led to diagnosis and cure of Diffuse Large B-cell lymphoma (DLBCL). Diabete...

Introduction: Primary hyperparathyroidism (PHPT) is disorder of one or more parathyroid glands, characterized by inadequately increased PTH secretion, almost always followed by hypercalcemia. Calcitonin, secreted by parafollicular C-cells in thyroid gland, is hypocalcemic hormone which partly acts as physiological antagonist of PTH.Aim: To evaluate calcitonin response in calcium infusion test in patients with primary hyperparathyroidism.<p class="abs...