Endocrine Abstracts

Introduction: Anorexia nervosa (AN) is a chronic disorder characterized of profound reduction in body weight and amenorrhoea. A product of complex interactions between psychological and clinical variables are important for the presence of the disease.Aim: The aim of the study was to investigate the variables which might predict full reproductive recovery of patients with anorexia nervosa.Material and methods: We studied closely mat...

Introduction: Both GH deficiency (GHD) and male hypogonadism are thought to be associated with an increased cardiovascular morbidity and mortality which is at least partly attributed to higher Insulin resistance. Potential reversibility of increased risk factors after gonadal replacement was assessed in this study, by comparing replaced and unreplaced hypogonadal men with GHD.Subjects and methods: Seventy-seven hypogonadal adult male patients with GHD ha...

Considering that adrenal tumors are frequent in patients with congenital adrenal hyperplasia (82% in homozygote and 45% in heterozygote), Synacten test was at first introduced as marker of congenital adrenal deficiency in patient with adrenal incidentaloma. Recent studies showed normal and exaggerated cortisol response in more than 50% of patient with nonhypersecretory adrenal incidentaloma and more than 70% of patients with adrenal incidentaloma and subclinical hypercorticism...

Aim/hypothesis: Chronic renal failure maintenance hemodialysis (HD) patients are at risk for low bone mineral density (BMD) and fractures. Parathyroid hormone (iPTH) plays a pivotal role in the pathophysiology of uremic bone disease, but in healthy population body weight and particularly body composition are more important determinants of bone mass.Patients and methods: We studied BMD (results were recorded as g/cm2) and T score using D...

Anorexia nervosa (AN) is a chronic disorder characterized of profound reduction in body weight and amenorrhoea. Despite emaciation and avoidance of cholesterol-rich food, hypercholesterolaemia is a common feature. The aim of the study was to investigate the changes in lipid metabolism with weight gain in 17 severe AN patients aged 23.8±1.6 years (DSM-IV criteria). They were compared with age-matched cohorts of 11 healthy controls (22.5±3.9 years) before and after wei...

Growth hormone deficiency (GHD) impairs bone mass and strength. Androgen deficient men exhibit impaired bone mass, but the extent to which testosterone replacement can prevent this remains disputable. The aim of this study was to assess whether androgen deficiency presents an additional risk factor for bone health in male patients with GHD and whether this is correctable by testosterone substitution.A group of 81 male patients with GHD, not receiving GH ...

Previous studies have shown exaggerated ACTH and cortisol responses to ghrelin. Seven patients who were cured by transsphenoidal operation from CD were included in the study and tested with ghrelin (1 mcg/kg i.v.) before and six months after the operation. Their results were compared with eight healthy control subjects. Results are presented as mean±S.D. Mann–Whitney and Wilcoxon signed rank test were used for statistical analysis.<p class="abstext...

Many studies have shown insulin resistance (IR) in majority of patients with adrenal incidentaloma. The euglycaemic hyperinsulinaemic glucose clamp technique is still considered as ‘golden standard’ for evaluation of insuline sensitivity. These methods are also complicated, labor-intensive procedure better for small research studies. Today, several surrogate indexes for insulin sensitivity were introduced such as: HOMA, QUIQI or G/IR. Some studies showed that QUIQI h...

Obesity protects from osteoporosis. Bone remodeling and energy metabolism could be regulated by the adipocyte-derived hormone, leptin acting on osteoblasts though hypothalamic pathways. Hypothalamic lesions cause obesity. Since most of these patients are also hypopituitary with low IGF1 which could affect bone metabolism the aim of our study was to investigate whether obesity would protect them from osteoporosis.Three groups of patients were studied: (1)...

Anorexia nervosa (AN) is associated with bone loss due to weight loss, decreased caloric intake, amenorrhoea and behavioral changes. The most important predictor of the occurrence of bone loss is body weight (BMI <16.5 kg/m2). Previous studies suggested that many factors including effects of chronic undernutrition in AN patients is associated with a reduction of bone formation (osteocalcin-OC) uncoupled with increased resorption markers (crosslaps-CTx). The aim ...