Endocrine Abstracts

Introduction: Leptin, adipose-tissue-derived hormone has a prominent role in bone remodeling by activating, through CNS relay, the sympathetic tone which inhibits bone formation. Schizophrenia is a CNS disease associated with low bone mass and changes in bone remodeling. Risperidone, atypical antipsychotic, may be related to increase in body weight (BW). Increased BW is thought to be protective to the bone.Aim: To determine relations between leptin, bone...

Sy Sheehan or postpartal pituitary necrosis presents with symptoms and signs of hypopituitarisms. It is usually a consequence of complicate delivery followed by intensive uterine bleeding. Diagnosis can be delayed years after delivery, up to 20 years.We present a case of 51-year-old female patient. She was admitted in the department of neurology in the Emergency center, Belgrade, with disturbance of consciousness. Few days before she felt leg weakness an...

Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to postmenopause in women. Both are well recognized predictors of cardiovascular disease and diabetes in women.The objective of this study was to assess the presence of obesity and metabolic syndrome during the menopausal transition in women from Serbia.Methods: Our results present a part of the National epidemiological cross-sectional st...

Introduction: Cushing’s syndrome (CS) results from inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality.Case report: A 38-year-old woman with a typical appearance of CS was admitted for further evaluation of hypercortisolism. The serum cortisol level was elevated without diurnal rhythm, with no adequate supression of cortisol after 1 mg dexamethasone suppresion test. Twenty-four-hour urinary free...

According to the novel concept bone remodeling is centrally regulated (CNS). Leptin the adipocyte derived hormone acts on hypothalamus and by increasing sympathetic activity acts on osteoblasts to regulate bone formation. In patients with schizophrenia several factors have influence on bone metabolism. Schizophrenia per se, as a disease of central nervous system is associated with increased occurence of osteoporosis. Hyperprolactinemia as consequence of antipsychotic tr...

Spontaneous subarahnoid hemorrhage (SAH) is a recently identified risk factor for hipopituitarism, especially growth hormone (GH) and corticotroph deficiencies. The aim of this study is to perform the initial screening procedure to identify the patients with increased risk of neuroendocrine dysfunction after SAH in the chronic phase and to identify the possible predictor(s) for neuroendocrine dysfunction. Ninety-one patients (30 males, 61 females), age between 19 and 69 years ...

Aim: The aim of the study was to examine the existence of cardiovascular diseases (CVD), atherosclerotic factors and antioxidant defense in patients with central retinal artery and central retinal vein occlusions (CRAO, CRVO) and anterior ischemic optic neuropathy (AION).Materials and Methods: The study included 38 obese individuals with CRAO, CRVO and AION. Glycoregulation disorders were determined by OGTT. Lipid status was determined by spectrophotomet...

Involutive hypoandria (late onset hypogonadism) is characterized by decline in serum testosterone and increase of gonadotropins. Changes of hypothalamo-pituitary-testicular axis sensitivity are influenced by primary testicular changes and altered neuroendocrine regulation during aging. To evaluate age-related changes in gonadotroph and Leydig cell sensitivity two groups were formed: 1) 35 men, 51.8±3.2 years old, BMI=28.2±3.1 kg/m2; 2) 32 men, 63.2±6....

We have previously shown impaired neuroendocrine responses to ghrelin in patients with AN. The aim of this study was to investigate the metabolic responses during infusions of active ghrelin in severly malnourished patients with AN and compare them with responses of amenorrhoic AN patients who recovered body weight (PRAN) and constitutionally thin subjects (CTS) with regular menstrual cycles and without history of eating disorder and recent weight loss. Study was approved by t...

Adrenal incidentalomas are referred as clinically silent adrenal masses discovered incidentally during diagnostic testing or treatment for conditions not related to suspicion of adrenal disease. Certain percent of them are hormonally active and autonomous cortisol secretion is reported with increasing frequency. The aim of the study was to assess value of 1mg-DST in subclinical Cushing’s syndrome (CS) compared to the other forms of adrenal incidentalomas. We have evaluate...