Endocrine Abstracts

Premature ovarian failure (POF) is characterized by amenorrhea, hypergonadotropism and hypoestrogensm in women under 40 years. Sex steroids play an important role in maintaining bone mass and cessation of ovarian function results in significant bone loss.Objective: To evaluate bone mass density (BMD) and factors influencing it in women with POF.Design & methods: First group of 144 women with spontaneous POF (I), 39.7±7.6 y...

Subclinical hypothyroidism is defined as a biochemical abnormality characterized by an elevated serum level of sTSH with normal thyroid hormones (FT4) and no clinical symptoms. The objective of this study was to asses whether patients with subclinical hypothyroidism have a risk of hypercholesterolemia. We have evaluated 37 adults (34 female and 3 male), mean age 49.20±9.65 years, with laboratory confirmed subclinical hypothyroidism, sTSH value above of 4.5 mU/L and normal...

Objective: People are at higher risk for malignancy as they get older or have a strong family history of cancer.Aim: To collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in Outpatient clinic from years 2005–2017.Results: Overall 46% of 1100 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas whi...

Background: Thyroid function regulates a wide array of metabolic parameters and significantly affects lipoprotein metabolism. Subclinical hypothyroidism (SCH) is the most common thyroid disorder, with a prevalence up to 10% in adult populations. Subclinical hypothyroidism is defined as mild elevation in thyroid stimulating hormones (TSH) in presence of normal free thyroxine (fT4) and free triiodothyronine (fT3). This mild elevation of serum TSH is caused by a minor initial dec...

IntroductionMultiple myeloma is a haematological malignancy arising from plasma cells. It accounts for 10% of all haematological malignancies. Myeloma usually occurs in people over the age of 65, however, we have noted an increase occurrence of people with a younger age.Case ReportA 68 year old male, with background of hypertension and right total hip replacement, was referred to the outpatient haematology; a...

Background: Ectopic Cushing’s syndrome (ECS) frequently represents a diagnostic challenge due to its complex clinical presentation.Case presentation: A 57-year-old male presented with typical Cushingoid appearance, high adrenocorticotropic hormone (ACTH) level (138.3 pg/ml), lack of cortisol circadian rhythm and suppression in overnight 1 mg dexamethasone suppression test (DST) (1374 nmol/l). Great daily fluctuation of serum cortisol levels from ver...

We present a 70-year-old female who was initially referred to the endocrinology clinic for an assessment of her type 2 diabetes mellitus. She has a complex medical history including treated hypothyroidism, mastectomy for breast cancer and ongoing yearly surveillance for an excised benign lung lesion. On further questioning she acknowledged feeling generally unwell in the days prior to her appointment and had self-presented to the emergency department with undiagnosed hypertens...

Introduction: Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition in which women have fragile fractures associated with significant reduction of BMD during pregnancy or postpartum period.Case report: A 37-year-old female patient was admitted at our Clinic for further investigation of aetiology of osteoporosis in July 2019. Soon after delivery in February 2019 patient had felt left hip and foot pain as well as sharp intensive pain (i...

Background: Optimal testing of beta-cell dysfunction is still elusive. Oral based solid-food tests could superiorly approximate real-life stimulation by incorporating incretin activation. Increased body fat was recently associated with better preserved beta-cell secretory response, due to gluco-lipotoxicity induced adaptation.Objective: To assess C-peptide response to standardised test meal (STM) and its dependency on subject characteristics in newly dia...

Background: Vascular complications are leading cause of increased morbidity and mortality of diabetic patients. Pathophysiological mechanisms included in the development and progression of diabetic complications are various and lately it has been postulated that matrix metalloproteinases MMP-2 and MMP-9, zinc-dependent endopeptidases through remodeling of extracellular matrix can contribute to the onset and progression of diabetic vascular complications. The aim of our study w...