Endocrine Abstracts

Context: Rising evidence of the increased risk in mild PHPT suggests that serum calcium, which has been a main surgical criterion, maybe not an accurate indicator of disease severity or at least, not a reliable predictive factor of its long-term consequences. This study aims to identify the best biochemical predictor of adverse outcomes in untreated PHPT.Outcome measures and methods: Primary outcomes considered were all-cause mortality, fatal and non-fat...

A 76-year-old man with history of oesophageal carcinoma was successfully treated by surgery and radiotherapy 4 years previously. He presented with anorexia and 4 stones weight loss associated with abdominal discomfort. He was not on any medication. On examination blood pressure 100/60, no peripheral oedema, systemic examination otherwise was unremarkable. Soon after admission, he developed a generalised tonic clonic seizure requiring a Lorazepam and Phenytoin infusion to contr...

Introduction: CT renal tract is commonly requested by the urologists for suspected renal colic as it is recognized as the most accurate technique for the detection of ureteric stones. However, follow-up of adrenal incidentalomas identified on such scans could pose a challenge for the non-endocrinologist. We investigated the prevalence and follow-up of incidentally discovered adrenal masses after CT renal colic.Methods: We looked through the reports of al...

Multiple endocrine neoplasia 1 (MEN-1) is an inherited autosomal dominant tumour syndrome affecting mainly the parathyroid gland, pituitary and pancreas. Genetic defect appears to be deletion mutation of MEN1 gene coding for tumour suppression. We describe a case of MEN1 mosaic mutation never reported in the literature.The index case presented aged 52 in 1985 with headaches and dizziness when hypercalcemia of 3.2 mmol/l was noted. Past medical history in...

Aim: We present an unusual case of long-term accidental ingestion of androgenic steroid in a young female.Case: A 28-year-old lady presented with male pattern of hair growth, weight gain of three stones, change in voice, and secondary amenorrhea. On direct questioning she admitted she was taking ‘fat bursting pills’ for nearly 6 months, obtained from a gym, to lose weight. Examination revealed a blood pressure of 150/77 mmHg, increased muscle b...

Background: Primary hyperparathyroidism (PHPT) is a common condition, which in some patients can lead to complications such as osteoporosis and renal stones. This survey investigated diagnosis and treatment strategies for PHPT across Europe.Methods: The survey was conducted in five European countries (France, Germany, UK, Italy and Spain). 286 of the 421 interviewed physicians were endocrinologists; the remainder were rheumatologists (46), internists (50...

The coexistence of multiple adenomas in endocrine glands has been described in the context of the syndromes of multiple endocrine neoplasia. However, recently the presence of adenomas in multiple endocrine glands has been described in patients not fulfilling the criteria of the syndromes of multiple endocrine neoplasia.The aim was to describe the case of a patient with a pituitary gonadotrophinoma who presented with primary hyperparathyroidism caused by ...

MEN1 syndrome is an autosomal dominant inherited disease characterised by primary hyperparathyroidism in association with endocrine enteropancratic tumors and anterior pituitary adenomas. Tumours of the pituitary gland as the first manifestations of MEN1 are very rare in children.Clinical case report: A 13-year-old boy presented with clinical signs suggestive of Cushing’s syndrome. He had decreased growth rate, muscle weakness, headaches and truncal...

Primary hyperparathyroidism (PHP) is one of the most common endocrine diseases; it is frequently found in asymptomatic patients when there is some doubt as to the appropriate choice of surgery (PTX), medical therapy or watchful waiting. These decisions are generally based on the consensus guidelines produced by the NIH however there is concern that these reflect established medical/surgical practice in the USA as much as clinical evidence. What evidence that does exist is freq...

Familial benign hypocalciuric hypercalcaemia (FHH) is a lifelong, benign, inherited condition with slightly increased levels of plasma calcium, low urinary calcium excretion, and normal to moderately elevated plasma parathyroid hormone (PTH). In most cases, FHH (type-1) is caused by inactivating mutations in the gene encoding the calcium sensing receptor (CASR) expressed in the parathyroids and the kidneys. The estimated prevalence of FHH is 1 in 78 000 compared with that of p...