Endocrine Abstracts

Glucocorticoid signalling is essential during embryonic lung development, with both the global and epithelial glucocorticoid receptor (GR) null mice presenting with lung atelectasis and post natal lethality. In this study, we examined the role of glucocorticoid signalling within mesenchymal tissues. To study the role of the GR in mesenchymal tissues during embryogenesis we crossed GRflox mice with Dermo1-Cre mice to generate GRDermo1 mice, where the GR gene was cond...

Background: CLDN14 gene encodes a protein involved in regulation of paracellular permeability or ion transport at epithelial tight junctions as in the nephron. C allele of the rs219780 SNP of CLDN14 gene has been associated with high levels of PTH and with low bone mineral density (BMD) in women. Our aim is to study the relationship between rs219780 SNP of CLDN14 and fractures, renal lithiasis and bone mineral density in patients with primary hyperparathyr...

Background: Hypoparathyroidism (HypoPT) is a rare condition that is characterized by hypocalcemia and hyperphosphatemia due to low or inappropriately normal serum levels of parathyroid hormone (PTH) for at least 6 months. The long-term complications of hypoparathyroidism indicate the necessity of screening them. In the follow-up of these patients according to hypoparathyroidism guidelines is recommended; calcium, phosphorus, albumin, magnesium, creatinine, and eGFR levels shou...

Over 60 generations we have inbred a strain of rats to maximize urine calcium excretion, the most common metabolic abnormality in human stone formers. The rats now excrete 8 - 10 times as much calcium as controls and uniformly form kidney stones. They have been termed genetic hypercalciuric stone forming (GHS) rats. The GHS rats exhibit metabolic abnormalities similar to patients with idiopathic hypercalciuria in that they absorb excessive amounts of intestinal calcium, they f...

Pancreatitis has multiple aetiologies of which commonest are gall stones and alcohol. Hypertriglyceridaemia is a less common (1-14 %) cause of pancreatitis. We present three case histories of acute pancreatitis due to severe triglyceridaemia and its management challenge in people with diabetes.Case history: 1. A 33-year-old man with BMI of 41 kg/m2 with Hodgkin lymphoma, thyrotoxicosis and diabetes, but no history of alcohol use was diagnosed ...

Background: Peptic ulcer bleeding due to primary hyperparathyroidism is extremely rare and only a few cases have been reported in the literature.Material and methods: Man with repeated upper gastrointestinal bleeding, with a history of kidney stones and previously unknown primary hyperparathyroidism.Case: Man M., 46 y.o., with a history of 4 episodes of gastrointestinal bleeding and a ten-year history of multiple kidney stones. In ...

Objective: To know the prevalence of primary hyperparathyroidism (PHPT) in urolithiasis and predictors of PHPT in urolithiasis.Methods: This cross sectional study was conducted between July 2005 and July 2012 in department of endocrinology and urology at our hospital. In this study a total of 165 consecutive patients with urolithiasis with radioopaque stones were evaluated for clinical and biochemical profile. Stones retrieved were analyzed for type of s...

Objective: To know the prevalence of primary hyperparathyroidism (PHPT) in urolithiasis and predictors of PHPT in urolithiasis.Methods: This cross sectional study was conducted between July 2005 and July 2012 in Department of Endocrinology and Urology at our hospital. In this study a total of 165 consecutive patients with urolithiasis with radioopaque stones were evaluated for clinical and biochemical profile. Stones retrieved were analyzed for type of s...

Introduction: Hypercalcaemia is a commonly encountered biochemical abnormality. The most common causes of hypercalcaemia are primary hyperparathyroidism and malignancy. Familial Hypocalciuric Hypercalcaemia (FHH) is a rare cause of hypercalcaemia.Case: We present a 53-year-old female, who was referred to the endocrinology clinic for further investigation of a persistent hypercalcaemia associated with low-to-normal parathyroid hormone level (1.5pmol/l). S...

Introduction: Nephrolithiasis and bone disease are the most common complications of primary hyperparathyroidism (PHPT). The aim of this study was to evaluate the relationships between the existence of kidney stones, renal function and bone mineral density (BMD) in PHPT.Description of methods/design: Biomedical evaluation, BMD measurements and renal ultrasonography were performed in a group of 75 consecutive PHPT patients aged 57.6±12.7 years. The co...