Endocrine Abstracts

Aim: The main aim of this study was to evaluate the prevalence of kidney stones and osteoporosis in a cohort of patients with a confirmed diagnosis of primary hyperparathyroidism (PHPT).Study design: This retrospective study reviewed the clinical records of patients with a confirmed diagnosis of PHPT in a single tertiary referral centre for metabolic bone disease over a period of 6 years (January 2010 – December 2015).Patients...

Aim: To evaluate the prevalence of kidney stones and osteoporosis in a cohort of patients with a confirmed diagnosis of primary hyperparathyroidism (PHPT).Study Design: This retrospective study reviewed the clinical records of patients with a confirmed diagnosis of PHPT in a single tertiary referral centre for metabolic bone disease over a period of 6 years (January 2010 – December 2015).Patients: There ...

Aim: To evaluate the prevalence of kidney stones and osteoporosis in a cohort of patients with a confirmed diagnosis of primary hyperparathyroidism (PHPT).Study Design: This retrospective study reviewed the clinical records of patients with a confirmed diagnosis of PHPT in a single tertiary referral centre for metabolic bone disease over a period of 6 years (January 2010 – December 2015).Patients: There ...

Introduction: The recent advent of flexible ureteroscopy made endoscopic approach to kidney and proximal ureteral calculi evolve to a real effective procedure. However, this technique is not free of postoperative complications. The aim this study was to assess the predictive factors of septic postoperative complications following flexible ureteroscopy for upper urinary tract stones.Methods: This is a descriptive retrospective study concerning 92 patients...

Background: Kidney stones have been linked to chronic kidney disease and a higher probability of adverse cardiovascular events. Precise mechanisms that lead to these complications have not yet been elucidated. Most cases of kidney stones are idiopathic, related to metabolic disturbances like hypercalciuria, which often have a genetic background. There have been few reports of kidney stones associated with primary hyperaldosteronism (HA); however, the prevalence of HA in patien...

Primary hyperparathyroidism (PHPT) is associated with increased risk of kidney stones. Hypercalciuria and urine oxalate excretion are considered risk factors for urolithiasis in PHPT stone-formers. Recently, the anion-exchanger SLC26A6 has been involved in the oxalate metabolism. Slc26a6-null mice showed hyperoxalemia, hyperoxaluria resulting in dramatic calcium oxalate urolithiasis. We tested the hypothesis that urine oxalate excretion in PHPT patients might be modulat...

Primary hyperparathyroidism (PHP) is a common endocrine condition. The associated metabolic abnormalities are usually amenable to surgical treatment (PTX). Although it is generally believed that such treatment will reduce the risk of long-term complications this has not been demonstrated in a clinical trial and the current treatment guidelines are based on consensus. In order to assess the effect of parathyroidectomy on two of the most common complications of PHP, renal stones...

The vitamin A-derived hormone retinoic acid (RA) is best known for its essential role in development, but components of the RA signalling pathway are also expressed in regions of the adult brain, including the hypothalamus, which regulates feeding behaviour, metabolism and body weight. RA is synthesised by the tanycytes lining the third ventricle and has recently been found to regulate cell proliferation in the hypothalamus. Some animals, such as the hamster and F344 rat, alte...

Tanycytes line the wall of the third ventricle sitting at the boundary between the cerebral spinal fluid (CSF) and the hypothalamus. Tanycytes actively take up substances from the CSF using their villi-like apical projections that extend into the third ventricle. Retinol is one such compound and can be oxidized by these cells to retinoic acid, which can be released to regulate transcription in the hypothalamus via specific nuclear receptors. Two retinal dehydrogenases (RALDHs)...

We developed an improved process for producing high quality 67Cu using an electron accelerator instead of a high energy proton accelerator. The beta/gamma emitting radioisotope 67Cu was created using the (g,p) reaction on isotopically enriched 68Zn target (nominally 40 g, 98% enrichment). The high energy photons were produced by bremsstrahlung conversion of electrons from a 45 MeV electron LINAC. A specially designed water cooled converter, end...