Endocrine Abstracts

Background: Conventional treatment for chronic hypoparathyroidism (CHP) is Vitamin-D analogues and calcium supplementation, not replacement of lacking hormone, as done in other hormone-deficiency states.Objectives: Retrospective evaluation of CHP management in line with European Society of Endocrinology Guideline was undertaken, to assess adequacy of calcium-homeostasis and morbidity.Methodology: Retrospective case-note and electro...

Patients with primary hyperparathyroidism (PHPT) are at risk of chronic kidney disease (CKD). PHPT patients (n=190, 146 females and 44 males, aged 59.7±14.2 years) and non-hypertensive, non-diabetic age- and sex-matched healthy controls were evaluated for serum cystatin C and creatinine. PHPT patients and controls with established CKD were excluded. Serum cystatin C was measured by immunonephelometric assay and calculation of estimated glomerular filtration rate ...

Introduction: Risk of vertebral fracture (VFx) is in part independent of bone mineral density (BMD) in primary hyperparathyroidism (PHPT). The aim of this study was to examine whether other factors, including the genotype of common polymorphisms in the calcium-sensing receptor (CASR) gene, are associated with VFx.Patients and methods: In 266 Caucasian PHPT patients, serum calcium, phosphate, creatinine, total alkaline phosphatase, intact PTH, 25-hydroxyv...

Introduction: Diabetes is associated with increased fracture risk both in patients with type 1 (T1D) and type 2 diabetes (T2D) despite differences in bone mineral density BMD (decreased in T1D and increased in T2D). In T2D, insulin resistance (IR) is selective, with some insulin signaling pathways impaired, while others are overactive due to hyperinsulinemia. It is not clear how different insulin signaling pathways might contribute to the bone phenotypes observed in diabetes. ...

Introduction: Primary hyperparathyroidism (PHPT) is generally associated with increased fracture risk at all skeletal sites although greater bone loss is observed at the cortical than the trabecular bone sites. AsBMD alone does not adequately predict fracture risk, trabecular bone score (TBS) is proposed as a new method supporting risk assessment.The aim of this study was to investigate correlation between TBS andthe severity of primary hyperparathyroidi...

A 30-year-old male was admitted to the neurotraumatology ward after head trauma with cerebral concussion, subdural & subarachnoidal haemorrhage. The Endocrinologist was called to evaluate high urinary debits. The patient was healthy until 4 years before admission. He enrolled on variate patterns of alimentary restriction that resulted in the loss of 28 kg. Since then he had visited multiple doctors (Cardiology, Haemathology, Psychiatry, Gastroenterology, Urology, Endocrino...

Background: Endocrine-related adverse effects of immune check-point inhibitors (ICIs) have been identified in growing number of cancer patients.Case presentation: A 49-year-old male with laryngeal cancer applied to ouroutpatient clinic with weakness, loss of appetite, weight loss, nausea and vomiting for the last three weeks. He was diagnosed with T3N1M0 laryngeal squamous cell cancer seven months before this admission and was given concurrent cisplatin ...

Introduction: Parathyroid carcinoma (PC) is an extremely rare, aggressive and life-threatening form of primary hyperparathyroidism (pHPT). PC accounts for less than 1% of cases of pHPT, predominantly diagnosed in the fifth or sixth decades of life. Most parathyroid carcinomas are diagnosed after surgery.Case description: A 51-year old man was admitted to the Hospital of Lithuanian University of Health Sciences, Kaunas clinics due to leg pain and general ...

A 42 year old male patient was admitted to the gastroenterology unit in due to severe abdominal pain and vomiting. He denied any chronic illness and drug usage. His family history was nonsignificant for any endocrine disease. Based on biochemical studies (lipase 2280 U/l, calcium 15.0 mg/dl, phosphorus 1.7 mg/dl amylase 631 U/l, creatinine 1.16 mg/dl, ALP 735 U/l) severe hypercalcemia induced acute pancreatitis was the diagnosis. 25 OH vitamin D was 5 ng/ml and parathyroid hor...

A 21-year-old woman with homozygous sickle cell disease, presented to A&E with vomiting and diarrhoea, and was noted to be hypercalcaemic (corrected calcium 3.00 mmol/l [ref. 2.2–2.6]; phosphate 0.48 mmol/l [ref. 0.8–1.5]). She reported polyuria and polydipsia, but no other symptoms of hypercalcaemia. There was no history of renal stones, renal impairment, or fragility fracture. A maternal aunt required parathyroidectomy in middle age. Bloods revealed PTH 138.4 pmo...