Endocrine Abstracts

A 30-year-old lady was initially seen in our clinic with a slight elevated corrected calcium with an elevated parathyroid hormone in March 2021. The elevated calcium [2.58mmol/l(NR: 2.10-2.55)] was first noted in 2018 when she had investigations for easy bruising, fatigue, breathlessness, and weight loss. The symptoms settled on their own and her calcium levels were monitored routinely. She was referred to our clinic when the corrected calcium had increased to 2.69mmol/lwith a...

Introduction: - Primary hyperparathyroidism is a relatively common disorder affecting 1 in 500 women and 1 in 2000 men aged over 40 years. - Diagnosis of primary hyperparathyroidism is confirmed biochemically with synchronous elevation of serum calcium and inappropriate elevation of parathyroid hormone. - Parathyroid adenomas are the most common aetiology. Around 80% are a single, benign adenoma, which in most cases is sporadic. Multiple adenomas and hypertrophy of all 4 gland...

A 35-year-old gentleman was referred to our Endocrinology department by Moorfields Eye hospital. He reported a one-year history of visual decline in his right eye, which led to prescription glasses, and incidental finding of bilateral conjunctival nodules. He had reduced visual acuity (pinhole right eye: 6/24 and left eye 6/6) and prominent corneal nerves on slit-lamp examination. He underwent an excisional biopsy of the conjunctival nodules confirming bilateral conjunctival n...

Case History: A 61-year-old Caucasian female from Ukraine presented with severe hypercalcaemia following routine blood tests performed by the GP. She reported symptoms of back pain and joint pains. She had renal stones 10 years prior. No history of thiazide or lithium use. No red flags; no change in appetite or weight loss. There was no familial history of Multiple Endocrine Neoplasia (MEN). Examination of her neck, cardiorespiratory, abdomen and breasts were normal. <p cl...

Case: 55 year old male presented with severe sharp and burning pain at anterior aspect of both legs (radiating from groin to feet), worse at night, unable to keep bed sheets lying on legs due to pain (allodynia). Patient reported weight loss of 3 stones in last 1 year including a recent 1 stone weight loss in 2 months. Patient is a type II DM for the last 3 years. He was intolerant to Metformin and is on Gliclazide 160 mg BD. Alcohol intake around 40 units per week. Initial in...

Section 1: Case history: 23 Year old Caribbean gentleman attended A&E with several month history of non-specific headaches, changes in memory/mood and joint pains. Since the age of 5 he had been medically treated for renal stones, He had a past medical history of sickle cell trait and was not on any regular medications. There was no significant family history apart from sickle cell disease. He had initial bloods which showed serum adjusted calcium level 3.7 mmol/l and PTH ...

Case history: A 74 years old gentleman with no medical illness presented with loss of consciousness in March 2018. CT head did not show acute cortical infarct but there was florid symmetrical calcification involving the basal ganglia, thalami, cerebellar lobes and subcortical white matter within the parietal-occipital lobes bilaterally. Fahr’s disease was suspected and an outpatient MRI was requested.Investigation and Results: 2 weeks later, a routi...

Case History: A 64 year old lady with osteoporosis was referred for parental antiresorptive therapy due to a history of oral bisphosphonate intolerance. She was screened for osteoporosis at age 53 after her mother suffered a hip fracture, DEXA showing an L2-L4 T score of −2.5 and mean femur −2.2. She was given a trial of alendronate, but stopped due to indigestion. On Calcium and Vitamin D supplementation, the DEXA after 4 years showed improvement of both the spine...

Case History: A 64 year old lady was referred for parental antiresorptive therapy due to a history of oral bisphosphonate intolerance. She had been screened for osteoporosis at age 53 after her mother had suffered a hip fracture, DEXA scan showed an L2-L4 T score of −2.5 and a mean femur −2.2. She was given a trial of alendronate, but had stopped due to indigestion. The DEXA scan at 4 years showed improvement of both the spine and femur densities on Calcium and Vit...

Introduction: We describe a case of a 29 year old man who was referred to endocrinology services with a 4 month history of erectile dysfunction, decreased libido and low testosterone. He denied symptoms suggestive of pituitary pathology. And he had no previous testicular infections or trauma. His past medical history included asthma, which was well controlled with b-agonist inhaler as required. He had normal development. He was a non smoker, abstinent from alcohol and a keen c...