Endocrine Abstracts

Patients with chronic hypoparathyroidism (HypoPT) treated with oral calcium and active vitamin D metabolites are at risk of renal complications, because of the lack of action of PTH at the renal tubule. In the present study we evaluated 90 patients (68 females and 22 males; age: 51.8±14.1 yrs) with chronic postoperative Hypo (PO-HypoPT) diagnosed since at least 3 years. All patients were treated with calcitriol and 35 (39%) with oral calcium two patients were also treated...

Introduction: Primary hyperparathyroidism is the most common cause of hypercalcemia in the outpatient setting, and a single parathyroid adenoma is usually the culprit. Clinical presentation is commonly dictated by hypercalcemia. Symptoms can range from mild non-specific malaise and gastrointestinal disturbances, through bone disease, kidney stones, cardiovascular and neuromuscular dysfunction to, ultimately, coma and death. However, the vast majority of patien...

Introduction: Parathyroid carcinoma is a rare malignancy of the parathyroid glands. Parathyroid carcinoma may be suspected, but it usually cannot be confirmed prior to operation.Case: A 35-year-old male was consulted to Endocrinology department with persistant kidney stones. He was operated five times in 10 years for recurrent kidney stones.His lab results are as follows; Ca:13(8.8–10.6), P:2.2 mg/dl(2.5–4.5), ALP:84U/L(3...

Background: After the gall bladder stones and alcohol abuse, dyslipidemia is among most frequent causes of acute pancreatitis, especially in youngsters. Some clinical signs can be useful to alleviate either a medical condition diagnosis confirmation or unraveling of its etiology.Aim: We present a case 30 years old male, presented with nausea, vomiting and diffuse abdominal pain. Three months before hospital admission, patient was unsuccessfully treated f...

We describe a case of a male who presented to a rheumatologist with hypercalceamia at the age of 22 in 1995. Investigations were incomplete and he was lost to follow up. He was referred to a general surgeon in 2002 as another blood test had showed hypercalcaemia of 2.8 mmol/l (2.2–2.6), parathyroid hormone 9.5 pmol/l (1.6–6.9). A spot urine calcium/creatinine excretion ratio was 0.014. It was felt he probably had primary hyperparathyroidism and he was managed conserv...

Sixty six year old gentleman was referred to clinic with hypercalcaemia. He suffered with low mood, “funny turns”, nocturia and loose stools with urgency to open bowels. He appeared tanned but no increase pigmentation in skin folds. There was no palpable lymphadenopathy or neck lump. The calcium levels were around three with low normal PTH of 3.7 (2.8 on repeat). He had not developed any complications like osteoporosis, fracture or renal stones secondary to hypercalc...

Background: There is no consensus on the optimal timing of surgery for primary hyperparathyroidism (PHPT) in MEN1. Experienced centres recommend subtotal or total parathyroid surgery with three and a half gland surgery along with thymic removal as a favoured procedure; but long-term outcomes have rarely been reported.Objective: To investigate the indications and outcomes for surgery in patients with PHPT in MEN1Methods: Review of c...

Idiopathic infantile hypercalcemia (IIH) constitutes a broad group of diseases with a common outcome namely, hypercalcemia. It is now recognized that mutations of the vitamin D catabolic cytochrome P450, CYP24A1 represent one of the major causes of IIH. Patients often present in neonatal life with transient hypercalcemia, but adults with hypercalciuria, renal stones & nephrocalcinosis also appear with CYP24A1 defects. Recently, there have been reports that pregnant females...

Primary hyperparathyroidism (PHPT) is a common endocrine disorder, with a prevalence of 1–4 per 1000, that increases to 21 per 1000 in age groups 55–75 years. PHPT may be cured in only one way: by surgical excision of the abnormal parathyroid tissue, which in ~85% of patients is due to a parathyroid adenoma. Double adenomas are found in ~4% of cases and parathyroid carcinoma in 1%. There is consensus that patients with markedly increased serum calcium concentrations,...

During last few decades primary hyperparathyroidism (PHP) evolved from the disease of ‘bones, moans, stones and groans’ to a disorder that is most commonly asymptomatic and incidentally diagnosed with increasing biochemical screening. At the same time different localization studies of the abnormal parathyroid gland(s) emerged. Because PHP is caused in more than 85% of patients with a single gland adenoma which can be reliably localized preoperatively, there has been ...