Endocrine Abstracts

Dementia describes a set of symptoms such as memory loss, difficulties with thinking, problem solving or language. Vascular dementia is a second most common type of dementia, rare under 65 year old. I report a case of 57- year-old woman with diagnosed dementia vascularis in Neurology department. Beside neurological diagnostic methods(brain scan-CT, MRI, Color Doppler of carotids, she had hypercalcaemia (2.96–3.04 mmol/l; normal range 2.20–2.60) as high calciuresis/24...

Status of carbohydrate metabolism in patients with hypercalcaemia and the influence of hypercalcemia on the risk of type 2 diabetes continue to be studied.Objective: To study the prevalence of type 2 diabetes in patients with hypercalcemia and in patients without hypercalcemia.Materials and methods: Continuous survey of 1000 people, average age 54.68±16.96 (727 women, 273 men) from 18 to 96 years. Examination: total calcium, t...

Introduction: In the whole world normocalcemic hyperparathyroidism (NC HPT) is an emerging entity and a growing problem. This disease is characterized by high levels of intact parathyroid hormone with normal total or ionized serum calcium. Our aim is to analyze its clinical and biological profile and its etiologies.Subjects and methods: We have studied 18 subjects with NC HPT. They all had routine analyses, plasma calcium and phosphorous, and assessment ...

A 37-year-old lady was referred to the endocrine clinic with a raised serum calcium of 2.73 mmol/l in the presence of an inappropriately raised parathyroid hormone of 8.7 pmol/l. Calcium:creatinine clearance ratio was elevated at 0.018, excluding familial hypercalcaemic hypocalciuria. Past medical history revealed an episode of renal stones 17 years ago but a renal ultrasound excluded nephrocalcinosis.A diagnosis of primary hyperparathyroidism was made.<...

Background: In some patients with primary hyperparathyroidism (PHPT), glomerular filtration rate (GFR) demonstrate decrease after parathyroidectomy (PTE). GFR may decrease immediately after surgery due to general anesthesia, but after a month not all patients restore kidney function; a decreased GFR is also observed after 1–2 years after surgery.Aim: To find the pre-surgical factors of GFR decrease after PTE.Methods: Patients ...

Background: Immobility can be associated with severe hypercalcaemia, especially when compounded by other risk factors such as concurrent hyperthyroidism and high dietary calcium/milk intake and associated complications such as renal stones and fractures.Clinical case: 59y female presented acutely with confusion, vomiting, constipation and muscle weakness. She had history of obesity, stable Crohn’s disease with no recent increase in colonostomy outpu...

Background: The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis has effects on renal growth and electrolyte regulation. However, data on adverse renal comorbidities such as renal cysts and stones in acromegaly is scarce. The current study aimed to investigate the prevalence of radiologically detectable renal comorbidities and possible related factors in the acromegaly population.Methods: A total of 125 patients with acromegaly (46.4&pm;11.6...

Introduction: Parathyroid adenomas are rarely large in size. Here, we present a giant cystic parathyroid adenoma presented with pancytopenia.Case report: Twenty two years old female presented with fatigue, bone pain, polyuria, a lump in the neck and pancytopenia. She had a pulsatile mass on the right side of the neck which compressed her trachea. She was evaluated by Hematology since her Hb was 4.7 g/dl, WBC was 2200 u/l platelet count was: 69 000 u/l. B...

Aim: To review the presentation, management and outcomes in adult patients with MEN1 attending a multidisciplinary clinic.Methods: Case notes and electronic records were reviewed in patients attending a tertiary centre clinic for care of MEN1.Results: Forty-eight patients were analysed; 46% were male and 54% female. Mean age was 49 years (range 14–89) and 4% were deceased. Eighty-five percent had confirmed MEN1 mutations and 2...

A 36-year-old gentleman presented to his GP 2 years ago with hypertension and was commenced on valsartan. In January 2008, he was noted to have mildly deranged LFT and abdominal ultrasound scan showed mild fatty liver infiltration and bilateral renal stones. He was referred to Urology for investigation of renal stones and a CT IVU showed multiple renal calculi, a 6×5×5 cm soft tissue enhancing lesion arising from the right adrenal gland and a 7 mm calcified density w...