Endocrine Abstracts

Introduction: The association of multiple myeloma (MM) with primary hyperparathyroidism (pHPT) is very infrequent. In addition pHPT may be overlooked or later diagnosed, because on the one hand certain clinical and laboratory characteristics of MM, such as hypercalcaemia, asthenia, osteoporosis and impaired renal function overlap with the elements of pHPT, on the other hand modern pHPT include non-classical (e.g. normocalcemic or mild clinical) forms. We present the case of a ...

Introduction: We present a case of neurosarcoidosis presenting with anterior hypopituitarism and hypothalamic syndrome.Case Report: A 38-years old Caucasian woman presented from primary care with six-month history of secondary amenorrhoea. Additionally she reported non-specific tiredness, postural dizziness, nausea and abdominal pains. Over the same period she noticed progressive weight gain of three stones, increased somnolence, lethargy and excessive s...

This 32 year old lady was referred in 2008 with Graves Disease. She presented with typical symptoms which included tiredness, shaking, palpitations, itching, eye redness, opthalmopathy, and exopthalmos. She had lost 3 stones over 3 months at Weight watchers. The GP had commenced carbimazole but she did not know the dose. In September 2008 results showed FT4 73.6, TT3 >12.5, TSH <0.05 and +TPO antibodies – >1300. This lady declined a referral to the ophthalmolo...

A 62-year-old man was referred from secondary care with a long history of recurrent ureteric colic, borderline hypercalcaemia with parathyroid hormone level in the low-normal range and a normal serum phosphate. There was no family history of kidney stones or osteoporosis and no history of childhood urinary infections.Repeated biochemistry at presentation was as follows: PTH 2.1 pmol/l (1.1–6.8), corrected calcium 2.56 mmol/l (2.15–2.55), phosph...

Cushing’s disease (CD) is a rare condition, associated with significant morbidities.The long-term morbidities in a series of patients with CD who presented in two tertiary referral centres between 01/1967-06/2009 were assessed. All information was collected as documented in the records of the patients.224 patients were identified (174 females) with median age at diagnosis 39 years (range 10–76 (females 38 (12–72) &#1...

Introduction: Parathyroid cysts constitute a rare cause of primary hyperparathyroidism (PHPT). PHPT may also rarely coexist with non-medullary thyroid carcinoma (NMTC).Case presentation: A 70-year old woman was admitted to our department for type 2 diabetes mellitus (T2DM) management. She also reported nephritic colics due to kidney stone disease. There were no reports for fractures, symptoms of hypercalcemia or obstructive neck symptomatology. Laborator...

Background: Primary hyperparathyroidism (PHPT) is characterized by abnormal regulation of PTH secretion by calcium. The most common clinical presentation of PHPT is asymptomatic (80% cases), followed less likely by the classical symptoms of bones, stones, abdominal moans, and psychic groans. The diagnosis of PHPT is usually first suspected because of the finding of an elevated serum calcium concentration along with a rise in Parathyroid hormone (PTH) level. Serum phosphorus le...

Acute pancreatitis in kidney transplant recipients is an infrequent complication with complex etiology. However, there was no enough data about chronic pancreatitis after kidney transplantation. Glucose intolerance occurs with some frequency in chronic pancreatitis, but overt diabetes mellitus usually occurs late in the course of the disease. We presented long-term course of a kidney transplant recipient who developed recurrent acute pancreatitis.Case re...

Introduction: Diabetic ketoacidosis (DKA) is a feature of type 1 diabetes mellitus, but it can develop in people with type 2 diabetes (T2DM) in the presence of precipitating factors. Antipsychotics have been associated with pancreatitis without DKA or hyperglycemia or acidosis with no evidence of pancreatitis. To our knowledge, there are few reports of patients who developed pancreatitis and DKA during treatment with antipsychotis. We present a case of a patient who developed ...

Primary hyperparathyroidism (PHPT) is a common and for the most part an asymptomatic endocrine disorder, usually discovered by routine biochemical screening, in western populations; and increasingly now in other parts of the word. It is characterized by abnormal calcium-PTH dynamics, manifesting with mild hypercalcemia, with increased or inappropriately normal plasma parathyroid hormone (PTH) levels. PHPT is most commonly seen in older post-menopausal women. In countr...