Endocrine Abstracts

The goal was todetermine the optimal methods of postoperative monitoring of serum thyroglobulin (Tg) in differentiated thyroid cancer (DTC). This research intended to compare the prognostic value of immunometric methods with different functional sensitivity (FS) for Tg measurement for detecting recurrent disease.Design: During 2010–2012 years, 76 patients with treated DTC (a total thyroidectomy and adjuvant radioiodine therapy) were included. All p...

CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. In addition, CY...

Introduction: One of the autoimmune non–diabetic hypoglycemia (NDH) causes is the formation of antibodies to insulin (AB–IRI) or Hirata disease (HD).Objectives: To determine the prevalence of AB–IRI level increasing in patients with suspected NDH of various genesis and in healthy individuals.Methods: 96 patients aged 18–80 years with suspected NDH were included in prospective study. In all patients we determ...

The aim of the study: To compare FNA cytological examination and histological examination results of follicular thyroid tumors (FTT) and to define clinical features of benign and malignant FTT.Materials: cases of patients with FTT, who underwent thyroid surgery in the Head Research Center for Endocrinology during the period 1998–2003, were studied retrospectively. The results of FNA and histological examination were evaluated particularly.<p cla...

Background: Thyrotoxicosis is a common disorder with a prevalence of 3% in females and 0.3% in males in iodine replete areas. The prevalence may be higher in areas of iodine deficiency. It is known to induce many cardiovascular effects. The most important complication of thyrotoxicosis is atrial fibrillation. We aimed to assess thyroid function in patients with atrial fibrillation and determine the frequency of thyrotoxicosis in this group.Methods: We st...

Aim: To estimate further results of treatment and outcomes in patients with subacute thyroiditis observed in the period from 1993 to 2005 years.Materials and methods: 102 patients (84 women, 18 men) with confirmed De Quervain’s subacute thyroiditis (SAT) were investigated and the findings were analysed retrospectively (clinical features, ultrasonography, laboratory tests). Ultrasound device (Hewlett Packard Image Point HX) with 7.5 – 10 MHz. Se...

Introduction: This problem has a major social and medical significance. The prevalence of secondary endocrine hypertension is around 40%, of which primary aldosteronism is up to 15% and is usually developed at working age. Despite of improvement of diagnostical two-step method of finding primary aldosteronism, none of these test results can be considered reliable because of false positive and false negative results. That’s why the problem of endocrine hypertension diagnos...

Introduction: Topical diagnosis of insulinoma is an actual problem due to the low detection rate of tumors (about 75%) and conflicting data about its localization in pancreas (more than 50%) when using different imaging techniques. This is partly due to the subjectivity of visualizing diagnosis specialists when describing the location of tumor. We assumed that multimodal imaging Fusion will improve the accuracy of topical diagnosis of insulinoma.Aim: To ...

IntroductionThe clinical cases of insulinoma patients with well-studied hereditary syndromes due to mutations in the MEN1, VHL, TSC1, and TSC2 genes are repeatedly described in the literature. At the same time, the hereditary nature of the pathology is highly probable in young patients with primary multiple lesions without mutations in these genes. In such cases, one can assume the presence of germline mutations in genes with the descr...

IntroductionThere is no consensus about the necessity of dehydroepiandrosterone (DHEA) replacement in women with adrenal insufficiency (AI).MethodsThe woman aged 44 with medical compensation of autoimmune 1-AI, 1-hypogonadism, osteoporosis took DHEA (tablets of 50 mg in every morning) during 4 months. Concomitant therapy: hydrocortisone, fludrocortisone, drospirenone+estradiol, colecalciferol, calcium car...