Endocrine Abstracts

Objective: The aim of the study was to assess the effectiveness and safety of long-term sibutramine therapy in routine clinical practice.Materials and methods: In total, 98 774 patients (82.3% women, 17.7% men), from 142 cities of the Russian Federation were enrolled in the PRIMAVERA program. The mean age of the patients was 39.39±10.38 years, the mean body weight was 99.1±14.28 kg, and the mean BMI was 35.7±4.41 kg/m2. Physicia...

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are commonly associated with coronary artery disease (CAD). Recent studies demonstrated that microRNAs (miRNAs) are involved in the pathogenesis of CAD.Aim: To study miRNA-26a, microRNA-33a and microRNA-33b expression in patients with obesity.Methods: MiRNAs were detected in peripheral blood samples of 66 patients, aged 48–65 years. Patients with BMI 30.0–39.9 kg/m...

Introduction: Lymphoma of the thyroid gland is an uncommon condition occurring primarily in older women. Most patients have a short history of enlarging thyroid or a neck mass causing tracheal compression. There is also a strong association between thyroid lymphoma and Hashimoto’s thyroiditis. The diagnosis is established by biopsy. The conventional approach to treatment is combination of radiation therapy with multi-agent chemotherapy, while there is no significant role ...

Introduction: Obesity and diabetes mellitus type 2 (T2DM) are considered as one of the major risk factor for coronary heart disease (CHD) development, but the mechanisms beyond this relationship still need to be clarified. miRNAs are supposed to be involved in regulatory mechanisms in this relationship.Aim: To determine miRNAs expression in patients with obesity and T2DM.Methods: MiRNAs were detected in peripheral blood of 43 patie...

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are associated with cardiovascular diseases (CVD). Fibrotic changes in obesity include several molecular processes, including activation of Transforming growth factor β (TGF-β). Recent data indicate the involvement of Fibroblast growth factor 21 (FGF-21) as an important metabolic regulator, and even biomarker of metabolic changes in obesity and T2DM.Aim: To determine TGF-β and FGF-2...

Introduction: Morbid obesity (MO) is associated with high frequency of type 2 diabetes mellitus (T2DM). Biliopancreatic diversion (BPD) is bariatric operation that results in rapid T2DM remission and increased GLP-1 levels. The aim of the study was to compare non-diabetic MO patients with normal weight controls and with patients who underwent BPD more than 2 years ago.Methods: Blood glucose levels, IRI, GLP-1, GIP and glucagon were measured during the or...

Introduction: Renin-angiotensin-aldosterone system (RAAS) plays a significant role in the development of arterial hypertension (AH) in obese patient. Angiotensinogen expression in adipose tissue decreases during fasting and increases in case of overeating, that leads to changes in blood pressure (BP). The aim of the study was to assess the impact of obesity on the activity of RAAS and its role in the development of hypertension.Methods: 60 women, mean ag...

Introduction: One of the manifestations of Munchausen syndrome is the deliberate injection of insulin to achieve hypoglycemia or artificial hypoglycemia. If human insulin is injected, we will always determine high level of insulin and low level of Cpeptideatthemomentofhypoglycemia. Incasesof insulin analogues injection the diagnos is maybe difficult when we use analyzers specific only to human insulin: the low level of IRI and C peptide will be determined.<p class="abstext...

Introduction: One of the autoimmunenon-diabetic hypoglycemia (NDH) causes isthe antibodies to insulinreceptor (AB-rIRI) formation and/orinsulin resistance type B (TBIR).Objectives: To determine the prevalence of increased AB-rIRI level in patients with suspected NDH of different genesis and in healthy individuals; to determine significance of AB-rIRI investigation in NDH diagnosis.Methods: In a prospective study we determined AB-rI...

Relevance: Question of standards of iodine intake in pregnant and lactating women remains relevant.Aim of study: to determine status and function of thyroid gland in pregnant and lactating women with and without antibodies to thyroid gland, on the background of taking different doses of iodine in 3 different regions of Russia with different iodine status.Materials and methods: This study included 414 women in the different trimeste...