Endocrine Abstracts

Aim: To estimate further results of treatment and outcomes in patients with subacute thyroiditis observed in the period from 1993 to 2005 years.Materials and methods: 102 patients (84 women, 18 men) with confirmed De Quervain’s subacute thyroiditis (SAT) were investigated and the findings were analysed retrospectively (clinical features, ultrasonography, laboratory tests).Results: There were 102 patients in the cohort within t...

Introduction: Obesity is one of the most common endocrine disorders. Obesity can either be a symptom of numerous diseases or be associated with them, including cases, when patient does not have other complaints besides excess weight. This should be considered before initiating obesity treatment.Case: A 42-year-old male visited endocrinologist, complaining of overweight. Minimum weight from his adulthood was 70 kg, maximum was for that moment–124.5 k...

Introductionsome authors propose to conduct consistently two additional tests for differential diagnosis (DD) of NDH with the main purpose to confirm or exclude the autonomous hyperinsulinemia (AH; insulinoma): determination the capillary beta-hydroxybutyrate (BHB) during prolonged fasting test (FT), and glucagon test (GT) at the moment of hypoglycemia. GT is more labor-intensive, high-cost and lead to potential complications. Therefore, we assumed that ...

Background: During pregnancy, the physiology of the thyroid gland undergoes important changes. As a result, change levels of thyroid hormones. In the latest clinical guidelines, experts have recommended to perform population-based studies to determine reference intervals for thyroid hormones.Aim: To evaluate the reference intervals of free thyroxine in different trimesters of pregnancy in women living in regions with mild iodine deficiency.<p class="...

Introduction: In Russia, full-scale studies aimed at assessing the incidence of endocrine autoimmune diseases (eAID) in adult patients with vitiligo have not been conducted.Objectives: analysis of occurrence of eAID in patients with vitiligo.Methods: 1) The first part of the study included 39 patients aged 19-73 years with endocrine pathology and vitiligo, who were initially examined in Endocrinology Research Centre. 2)The second p...

Purpose: To assess the level of biomarkers of early kidney damage (urinary and plasma cystatin C) in patients with prediabetes and to characterize their association with risk factors for the development of nephropathy.Materials and methods: The object of the study were 60 patients (32% men, 68% women) with early disorders of carbohydrate metabolism (impaired fasting glycemia (IFG) and impaired carbohydrate tolerance (IGT), WHO criteria, 2009). The mean a...

Introduction: Research into autoimmune disorders associated with COVID-19 in the middle of an ongoing COVID-19 pandemic is an important and urgent challenge. We focus on the potential relationship between coronavirus infection and other autoimmune diseases, and the positive therapeutic effect of the treatment of severe forms of COVID-19 with drugs traditionally used in the treatment of rheumatological diseases. The results of this study are a starting point for understanding t...

Purpose: To study the frequency of polymorphic alleles and genotypes of the PPARG (rs 1801282) gene and its effect on carbohydrate and lipid metabolism in patients with prediabetes.Materials and methods: The object of the study were 60 patients (32% men, 68% women) with early disorders of carbohydrate metabolism (WHO criteria, 2009). The mean age was 44.3 &pm; 7.8 years. The average value of fasting glycemia - 5.7&pm;0.42 mmol/l, the average level of gly...

Pregnant women are at risk of developing diseases associated with deficiency of essential micronutrients.Objective: To assess the prevalence of vitamin D deficiency among pregnant women and its dependence on the trimester of pregnancy.Methods: We examined 476 pregnant women at different gestational periods from three regions of Russia (Moscow, Ivanovo, Smolensk). Concentration of 25(OH)vitamin D (ng/ml) was estimated by immunometri...

Introduction: CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. I...